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公开(公告)号:US06458798B1
公开(公告)日:2002-10-01
申请号:US09763728
申请日:2001-02-27
申请人: Hitoshi Fujita , Fujio Antoku , Norio Fujiwara , Kiyotaka Iwai , Hiroshi Tanaka , Hajime Kawakami
发明人: Hitoshi Fujita , Fujio Antoku , Norio Fujiwara , Kiyotaka Iwai , Hiroshi Tanaka , Hajime Kawakami
IPC分类号: C07D23995
CPC分类号: C07D405/04 , C07D405/12 , C07D405/14
摘要: A pyrimidine derivative of the formula (1) or a salt thereof; has an inhibitory activity of production of Th2 type cytokines such as IL-4, IL-5, etc., and is useful as an therapeutic agent for allergic diseases, autoimmune diseases such as systemic lupus erythemathosus, etc., and acquired immunodeficiecy syndrome (AIDS) and so on.
摘要翻译: 式(1)的嘧啶衍生物或其盐具有产生Th2型细胞因子如IL-4,IL-5等的抑制活性,可用作过敏性疾病,自身免疫性疾病的治疗剂 如系统性红斑狼疮等,以及获得性免疫缺陷综合征(AIDS)等。
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公开(公告)号:US06951866B2
公开(公告)日:2005-10-04
申请号:US10222922
申请日:2002-08-19
申请人: Hitoshi Fujita , Fujio Antoku , Norio Fujiwara , Kiyotaka Iwai , Hiroshi Tanaka , Hajime Kawakami
发明人: Hitoshi Fujita , Fujio Antoku , Norio Fujiwara , Kiyotaka Iwai , Hiroshi Tanaka , Hajime Kawakami
IPC分类号: C07D405/04 , C07D405/12 , C07D405/14 , C07D491/044 , C07D491/052 , C07D239/49 , A61K31/505 , C07D239/48
CPC分类号: C07D405/04 , C07D405/12 , C07D405/14
摘要: 1. A pyrimidine derivative of the formula (1) or a salt thereof; has an inhibitory activity of production of Th2 type cytokines such as IL-4, IL-5, etc., and is useful as an therapeutic agent for allergic diseases, autoimmune diseases such as systemic lupus erythemathosus, etc., and acquired immunodeficiecy syndrome (AIDS) and so on.
摘要翻译: 1.式(1)的嘧啶衍生物或其盐; 具有产生Th2型细胞因子如IL-4,IL-5等的抑制活性,可用作过敏性疾病,系统性红斑狼疮等自身免疫性疾病等治疗剂,以及获得性免疫缺陷综合征 艾滋病)等。
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公开(公告)号:US07396842B2
公开(公告)日:2008-07-08
申请号:US11111845
申请日:2005-04-22
IPC分类号: A61K31/44 , C07D417/00
CPC分类号: C07D231/12 , C07D233/56 , C07D249/08 , C07D277/42 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14
摘要: A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur, R1 is hydrogen, substituted or unsubstituted alkyl, etc., R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y1 is a direct bond, substituted or unsubstituted alkylene, —CO(CH2)n—, etc., the wavy line means (E)-configuration or (Z)-configuration, R3 is substituted or unsubstituted aryl, etc., Y2 is substituted or unsubstituted alkylene, etc., R4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.
摘要翻译: 下式的5元环状化合物:其中X是氧或硫,R 1是氢,取代或未取代的烷基等,R 2是氢,被取代的 或未取代的烷基,取代或未取代的芳基等,Y 1是直接键,取代或未取代的亚烷基,-CO(CH 2)n, (E)构型或(Z)构型,R 3是取代或未取代的芳基等。Y 2 - 是取代或未取代的亚烷基等,R 4是氢,取代或未取代的烷酰基,取代或未取代的烷基等,R 5是氢等,或 其盐,这些化合物能够抑制白细胞如嗜酸性粒细胞和淋巴细胞的浸润,由此可用于治疗各种炎症。
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公开(公告)号:US20050222226A1
公开(公告)日:2005-10-06
申请号:US11111845
申请日:2005-04-22
IPC分类号: A61P29/00 , A61P37/06 , A61P37/08 , C07D277/42 , C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D521/00 , A61K31/426 , C07D277/38
CPC分类号: C07D231/12 , C07D233/56 , C07D249/08 , C07D277/42 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14
摘要: A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur, R1 is hydrogen, substituted or unsubstituted alkyl, etc., R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y1 is a direct bond, substituted or unsubstituted alkylene, —CO(CH2)n—, etc., the wavy line means (E)-configuration or (Z)-configuration, R3 is substituted or unsubstituted aryl, etc., Y2 is substituted or unsubstituted alkylene, etc., R4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.
摘要翻译: 下式的5元环状化合物:其中X是氧或硫,R 1是氢,取代或未取代的烷基等,R 2是氢,被取代的 或未取代的烷基,取代或未取代的芳基等,Y 1是直接键,取代或未取代的亚烷基,-CO(CH 2)n, (E)构型或(Z)构型,R 3是取代或未取代的芳基等。Y 2 - 是取代或未取代的亚烷基等,R 4是氢,取代或未取代的烷酰基,取代或未取代的烷基等,R 5是氢等,或 其盐,这些化合物能够抑制白细胞如嗜酸性粒细胞和淋巴细胞的浸润,由此可用于治疗各种炎症。
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公开(公告)号:US06919361B2
公开(公告)日:2005-07-19
申请号:US10312692
申请日:2001-06-28
IPC分类号: A61P29/00 , A61P37/06 , A61P37/08 , C07D277/42 , C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D521/00 , A61K31/425 , C07P277/08
CPC分类号: C07D231/12 , C07D233/56 , C07D249/08 , C07D277/42 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14
摘要: A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur, R1 is hydrogen, substituted or unsubstituted alkyl, etc., R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y1 is a direct bond, substituted or unsubstituted alkylene, —CO(CH2)n—, etc., the wavy line means (E)-configuration or (Z)-configuration, R3 is substituted or unsubstituted aryl, etc., Y2 is substituted or unsubstituted alkylene, etc., R4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.
摘要翻译: 下式的5元环状化合物:其中X是氧或硫,R 1是氢,取代或未取代的烷基等,R 2是氢,被取代的 或未取代的烷基,取代或未取代的芳基等,Y 1是直接键,取代或未取代的亚烷基,-CO(CH 2)n, (E)构型或(Z)构型,R 3是取代或未取代的芳基等。Y 2 - 是取代或未取代的亚烷基等,R 4是氢,取代或未取代的烷酰基,取代或未取代的烷基等,R 5是氢等,或 其盐,这些化合物能够抑制白细胞如嗜酸性粒细胞和淋巴细胞的浸润,由此可用于治疗各种炎症。
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公开(公告)号:US5948786A
公开(公告)日:1999-09-07
申请号:US69085
申请日:1998-04-29
申请人: Norio Fujiwara , Yutaka Ueda , Shinobu Murata , Fumiyo Hirota , Hajime Kawakami , Hitoshi Fujita
发明人: Norio Fujiwara , Yutaka Ueda , Shinobu Murata , Fumiyo Hirota , Hajime Kawakami , Hitoshi Fujita
IPC分类号: A61K31/506 , A61K31/517 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61K31/505 , C07D239/02 , C07D401/00
CPC分类号: C07D401/04 , A61K31/506 , A61K31/517 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要: A compound of formula (1) ##STR1## wherein X.sup.1 is amino or hydroxyl, X.sup.2 is carbonyl and the like R.sup.1 is an alkyl, an aryl and the like, R.sup.2 is hydrogen and the like, and R.sup.3 is an alkyl and the like, or a pharmaceutical acceptable salt thereof is effective for inibiting the production and/or secretion of tumor necrosis factor in a patient in need of such inhibition.
摘要翻译: 式(1)的化合物,其中X 1为氨基或羟基,X 2为羰基等,R 1为烷基,芳基等,R 2为氢等,R 3为烷基等,或药物 其可接受的盐对于在需要这种抑制的患者中抑制肿瘤坏死因子的产生和/或分泌是有效的。
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公开(公告)号:US06771495B2
公开(公告)日:2004-08-03
申请号:US10219551
申请日:2002-08-15
申请人: Norio Fujiwara , Yoshihiro Fukukawa
发明人: Norio Fujiwara , Yoshihiro Fukukawa
IPC分类号: H05K500
CPC分类号: G06F1/1616 , G06F1/1658 , G06F1/203 , G11B33/08 , G11B33/1426
摘要: An information processing apparatus includes a shock absorbing structure that dissipates heat generated from function units accommodated in a housing of the apparatus without lowering shock absorbing capacity. A plane-like good heat-conductive member is brought into contact both with the function unit generating heat and a heat conductive element of the apparatus.
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公开(公告)号:US06338854B1
公开(公告)日:2002-01-15
申请号:US09695454
申请日:2000-10-24
IPC分类号: A61K31215
CPC分类号: C07J63/008 , A61K8/63 , A61Q19/08
摘要: Photoaging skin care preparations and methods of treating wrinkled skin are described. The photoaging skin care preparations contain at least one triterpenoid derivative which is a substituted form of ursolinic, oleanolic, or betulic acid. The photoaging skin care preparations inhibit photoaging and prevent and ameliorate wrinkled skin. The methods of treating wrinkled skin involve applying an effective amount of the skin care preparation to the wrinkled skin.
摘要翻译: 描述了护理皮肤护理制剂和治疗皱纹皮肤的方法。 光老化皮肤护理制剂含有至少一种三萜衍生物,它是尿素,齐墩果酸或bet酸的取代形式。 光老化护肤品抑制光老化,预防和改善皱纹皮肤。 治疗皱纹皮肤的方法涉及将有效量的皮肤护理制剂施用于皱纹皮肤。
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公开(公告)号:US07280359B2
公开(公告)日:2007-10-09
申请号:US11005016
申请日:2004-12-07
申请人: Norio Fujiwara
发明人: Norio Fujiwara
CPC分类号: H01L23/373 , G06F1/203 , H01L23/367 , H01L2924/0002 , H01L2924/00
摘要: In a heat-radiating structure HRS1 in which heat generated in a heat-generating component built in a housing of an electronic apparatus is conducted to the outside, the central portion of a flexible graphite sheet that is folded and shaped so as to be elastic is thermally connected to the heat-generating component, and a flexible conductive member is applied to a portion in which the central portion is thermally connected to the heat-generating component.
摘要翻译: 在将内置于电子设备的壳体内的发热部件产生的热量导向外部的热辐射结构HRS 1中,柔性石墨片的中心部分折叠成形为弹性 被热连接到发热部件,并且柔性导电部件被施加到中心部分与发热部件热连接的部分。
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公开(公告)号:US06822856B2
公开(公告)日:2004-11-23
申请号:US10212067
申请日:2002-08-06
申请人: Norio Fujiwara
发明人: Norio Fujiwara
IPC分类号: H05K720
CPC分类号: G06F1/203 , G06F1/1632
摘要: A portable information processing apparatus, which can be sophisticated with an expansion unit while it can maintain dust-proof and water-proof capacities, is provided. A main body of a note PC is made from heat conductive material and sealed. When the expansion unit is hooked up to the main body, a cooling fan provided to the expansion unit blows cooling air directly to plural fins formed on a housing of the main body, thereby cooling the main body.
摘要翻译: 提供了一种便携式信息处理装置,其可以在扩展单元中复杂化,同时可以保持防尘和防水能力。 笔记本PC的主体由导热材料制成并密封。 当膨胀单元连接到主体时,设置到膨胀单元的冷却风扇将冷却空气直接吹向形成在主体的壳体上的多个翅片,从而冷却主体。
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