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公开(公告)号:US5948786A
公开(公告)日:1999-09-07
申请号:US69085
申请日:1998-04-29
申请人: Norio Fujiwara , Yutaka Ueda , Shinobu Murata , Fumiyo Hirota , Hajime Kawakami , Hitoshi Fujita
发明人: Norio Fujiwara , Yutaka Ueda , Shinobu Murata , Fumiyo Hirota , Hajime Kawakami , Hitoshi Fujita
IPC分类号: A61K31/506 , A61K31/517 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61K31/505 , C07D239/02 , C07D401/00
CPC分类号: C07D401/04 , A61K31/506 , A61K31/517 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要: A compound of formula (1) ##STR1## wherein X.sup.1 is amino or hydroxyl, X.sup.2 is carbonyl and the like R.sup.1 is an alkyl, an aryl and the like, R.sup.2 is hydrogen and the like, and R.sup.3 is an alkyl and the like, or a pharmaceutical acceptable salt thereof is effective for inibiting the production and/or secretion of tumor necrosis factor in a patient in need of such inhibition.
摘要翻译: 式(1)的化合物,其中X 1为氨基或羟基,X 2为羰基等,R 1为烷基,芳基等,R 2为氢等,R 3为烷基等,或药物 其可接受的盐对于在需要这种抑制的患者中抑制肿瘤坏死因子的产生和/或分泌是有效的。
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公开(公告)号:US20050222226A1
公开(公告)日:2005-10-06
申请号:US11111845
申请日:2005-04-22
IPC分类号: A61P29/00 , A61P37/06 , A61P37/08 , C07D277/42 , C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D521/00 , A61K31/426 , C07D277/38
CPC分类号: C07D231/12 , C07D233/56 , C07D249/08 , C07D277/42 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14
摘要: A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur, R1 is hydrogen, substituted or unsubstituted alkyl, etc., R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y1 is a direct bond, substituted or unsubstituted alkylene, —CO(CH2)n—, etc., the wavy line means (E)-configuration or (Z)-configuration, R3 is substituted or unsubstituted aryl, etc., Y2 is substituted or unsubstituted alkylene, etc., R4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.
摘要翻译: 下式的5元环状化合物:其中X是氧或硫,R 1是氢,取代或未取代的烷基等,R 2是氢,被取代的 或未取代的烷基,取代或未取代的芳基等,Y 1是直接键,取代或未取代的亚烷基,-CO(CH 2)n, (E)构型或(Z)构型,R 3是取代或未取代的芳基等。Y 2 - 是取代或未取代的亚烷基等,R 4是氢,取代或未取代的烷酰基,取代或未取代的烷基等,R 5是氢等,或 其盐,这些化合物能够抑制白细胞如嗜酸性粒细胞和淋巴细胞的浸润,由此可用于治疗各种炎症。
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公开(公告)号:US06458798B1
公开(公告)日:2002-10-01
申请号:US09763728
申请日:2001-02-27
申请人: Hitoshi Fujita , Fujio Antoku , Norio Fujiwara , Kiyotaka Iwai , Hiroshi Tanaka , Hajime Kawakami
发明人: Hitoshi Fujita , Fujio Antoku , Norio Fujiwara , Kiyotaka Iwai , Hiroshi Tanaka , Hajime Kawakami
IPC分类号: C07D23995
CPC分类号: C07D405/04 , C07D405/12 , C07D405/14
摘要: A pyrimidine derivative of the formula (1) or a salt thereof; has an inhibitory activity of production of Th2 type cytokines such as IL-4, IL-5, etc., and is useful as an therapeutic agent for allergic diseases, autoimmune diseases such as systemic lupus erythemathosus, etc., and acquired immunodeficiecy syndrome (AIDS) and so on.
摘要翻译: 式(1)的嘧啶衍生物或其盐具有产生Th2型细胞因子如IL-4,IL-5等的抑制活性,可用作过敏性疾病,自身免疫性疾病的治疗剂 如系统性红斑狼疮等,以及获得性免疫缺陷综合征(AIDS)等。
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公开(公告)号:US07396842B2
公开(公告)日:2008-07-08
申请号:US11111845
申请日:2005-04-22
IPC分类号: A61K31/44 , C07D417/00
CPC分类号: C07D231/12 , C07D233/56 , C07D249/08 , C07D277/42 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14
摘要: A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur, R1 is hydrogen, substituted or unsubstituted alkyl, etc., R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y1 is a direct bond, substituted or unsubstituted alkylene, —CO(CH2)n—, etc., the wavy line means (E)-configuration or (Z)-configuration, R3 is substituted or unsubstituted aryl, etc., Y2 is substituted or unsubstituted alkylene, etc., R4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.
摘要翻译: 下式的5元环状化合物:其中X是氧或硫,R 1是氢,取代或未取代的烷基等,R 2是氢,被取代的 或未取代的烷基,取代或未取代的芳基等,Y 1是直接键,取代或未取代的亚烷基,-CO(CH 2)n, (E)构型或(Z)构型,R 3是取代或未取代的芳基等。Y 2 - 是取代或未取代的亚烷基等,R 4是氢,取代或未取代的烷酰基,取代或未取代的烷基等,R 5是氢等,或 其盐,这些化合物能够抑制白细胞如嗜酸性粒细胞和淋巴细胞的浸润,由此可用于治疗各种炎症。
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公开(公告)号:US06951866B2
公开(公告)日:2005-10-04
申请号:US10222922
申请日:2002-08-19
申请人: Hitoshi Fujita , Fujio Antoku , Norio Fujiwara , Kiyotaka Iwai , Hiroshi Tanaka , Hajime Kawakami
发明人: Hitoshi Fujita , Fujio Antoku , Norio Fujiwara , Kiyotaka Iwai , Hiroshi Tanaka , Hajime Kawakami
IPC分类号: C07D405/04 , C07D405/12 , C07D405/14 , C07D491/044 , C07D491/052 , C07D239/49 , A61K31/505 , C07D239/48
CPC分类号: C07D405/04 , C07D405/12 , C07D405/14
摘要: 1. A pyrimidine derivative of the formula (1) or a salt thereof; has an inhibitory activity of production of Th2 type cytokines such as IL-4, IL-5, etc., and is useful as an therapeutic agent for allergic diseases, autoimmune diseases such as systemic lupus erythemathosus, etc., and acquired immunodeficiecy syndrome (AIDS) and so on.
摘要翻译: 1.式(1)的嘧啶衍生物或其盐; 具有产生Th2型细胞因子如IL-4,IL-5等的抑制活性,可用作过敏性疾病,系统性红斑狼疮等自身免疫性疾病等治疗剂,以及获得性免疫缺陷综合征 艾滋病)等。
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公开(公告)号:US06919361B2
公开(公告)日:2005-07-19
申请号:US10312692
申请日:2001-06-28
IPC分类号: A61P29/00 , A61P37/06 , A61P37/08 , C07D277/42 , C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D521/00 , A61K31/425 , C07P277/08
CPC分类号: C07D231/12 , C07D233/56 , C07D249/08 , C07D277/42 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14
摘要: A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur, R1 is hydrogen, substituted or unsubstituted alkyl, etc., R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y1 is a direct bond, substituted or unsubstituted alkylene, —CO(CH2)n—, etc., the wavy line means (E)-configuration or (Z)-configuration, R3 is substituted or unsubstituted aryl, etc., Y2 is substituted or unsubstituted alkylene, etc., R4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.
摘要翻译: 下式的5元环状化合物:其中X是氧或硫,R 1是氢,取代或未取代的烷基等,R 2是氢,被取代的 或未取代的烷基,取代或未取代的芳基等,Y 1是直接键,取代或未取代的亚烷基,-CO(CH 2)n, (E)构型或(Z)构型,R 3是取代或未取代的芳基等。Y 2 - 是取代或未取代的亚烷基等,R 4是氢,取代或未取代的烷酰基,取代或未取代的烷基等,R 5是氢等,或 其盐,这些化合物能够抑制白细胞如嗜酸性粒细胞和淋巴细胞的浸润,由此可用于治疗各种炎症。
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公开(公告)号:US08660451B2
公开(公告)日:2014-02-25
申请号:US13186643
申请日:2011-07-20
申请人: Hideo Yamaki , Shigetaka Kurosu , Nobuyasu Tamura , Hajime Kawakami , Yusuke Nishisaka , Keiki Katsumata
发明人: Hideo Yamaki , Shigetaka Kurosu , Nobuyasu Tamura , Hajime Kawakami , Yusuke Nishisaka , Keiki Katsumata
IPC分类号: G03G15/00
CPC分类号: G03G15/161
摘要: A cleaning device for cleaning a belt member, includes a cleaning blade; a removing member coming in contact with the surface of the belt member so as to remove foreign matter adhering on the surface of the belt member; and a contact pressure changing section to change a contact pressure between the removing member to the belt member, wherein, when the contact pressure between the removing member and a region of the belt member corresponding in position to a toner image to be not transferred to a paper sheet is made P1, and the contact pressure between the removing member and a region of the belt member corresponding in position to a toner image to be transferred to a paper sheet is made P2, the contact pressure changing section changes the contact pressure to satisfy the conditional formula: (P1
摘要翻译: 一种用于清洁带构件的清洁装置,包括清洁刮板; 与带部件的表面接触的去除部件,以去除附着在带部件表面上的异物; 以及接触压力改变部分,用于改变去除部件与带部件之间的接触压力,其中,当去除部件与带状部件的与未调色剂图像相对应的位置的区域之间的接触压力 将纸张制成P1,将去除构件与带构件的与调色剂图像相对应的位置的区域之间的接触压力设定为P2,接触压力改变部分使接触压力变化以满足 条件公式:(P1
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公开(公告)号:US20140041628A1
公开(公告)日:2014-02-13
申请号:US13997810
申请日:2011-02-24
IPC分类号: F02D41/00
CPC分类号: F02D41/00 , F02D11/105 , F02D37/02 , F02D41/0002 , F02D43/00 , F02D2200/0625 , F02D2250/18 , F02D2250/21 , Y02T10/42
摘要: When a change amount of any one of a demanded torque, a demanded efficiency, and a demanded air-fuel ratio exceeds a predetermined threshold value, an internal combustion engine control apparatus provided by this invention makes a temporary adjustment to a value of any one of a demanded torque, a demanded efficiency and instructed efficiency, and a demanded air-fuel ratio in accordance with a type of demanded engine performance that is currently being given priority among various performances demanded of the internal combustion engine. In the present control apparatus, an actuator for air amount control is operated in accordance with a target air amount calculated based on a demanded torque and a demanded efficiency, an actuator for ignition timing control is operated in accordance with an instructed efficiency, and an actuator for fuel injection amount control is operated in accordance with a demanded air-fuel ratio.
摘要翻译: 当要求扭矩,要求效率和所需空燃比中的任何一个的变化量超过预定阈值时,由本发明提供的内燃机控制装置进行临时调整, 根据目前在内燃机所要求的各种性能中优先考虑的要求的发动机性能的类型,要求的扭矩,要求的效率和指示的效率以及所需的空燃比。 在本控制装置中,根据要求转矩和要求效率计算出的目标空气量来操作用于空气量控制的致动器,根据指示的效率来操作点火正时控制的致动器,并且致动器 燃料喷射量控制根据所需的空燃比进行运转。
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公开(公告)号:US20120085318A1
公开(公告)日:2012-04-12
申请号:US13121325
申请日:2010-10-12
IPC分类号: F02D41/00
CPC分类号: F02D11/105 , F02D37/02 , F02D41/0002 , F02D41/1475 , F02D2041/1431 , F02D2041/1432 , F02P5/1504 , Y02T10/42 , Y02T10/46
摘要: A control device for an internal combustion engine provided by the present invention is a control device which can satisfy both a requirement relating to exhaust gas performance of the internal combustion engine and a requirement relating to operation performance by properly regulating a change speed of a required air-fuel ratio, in the internal combustion engine which uses torque and an air-fuel ratio as control variables. The control device receives the requirement relating to the exhaust gas performance of the internal combustion engine, and calculates an air-fuel ratio which satisfies the requirement as a required air-fuel ratio. When a predetermined reduction condition is not satisfied, an original required air-fuel ratio is directly determined as a final required air-fuel ratio. However, when the reduction condition is satisfied, the change speed is reduced by processing the signal of the original required air-fuel ratio, and determines the required air-fuel ratio with the change speed reduced as the final required air-fuel ration. The reduction condition includes a condition that the change amount of the original required air-fuel ratio, in more detail, a change amount per calculation period is larger than a predetermined air-fuel ratio change determination value.
摘要翻译: 本发明提供的用于内燃机的控制装置是一种控制装置,其能够通过适当地调节所需空气的变速来满足与内燃机的废气性能有关的要求和与运行性能有关的要求 - 燃料比,在使用转矩和空燃比作为控制变量的内燃机中。 控制装置接收与内燃机的排气性能有关的要求,并且计算满足要求的空燃比作为所需的空燃比。 当不满足预定的减少条件时,原始所需的空燃比被直接确定为最终所需的空燃比。 然而,当满足减速条件时,通过处理原始所需空燃比的信号来降低变速,并且随着最终所需空燃比降低变速而确定所需的空燃比。 还原条件包括原始所需空燃比的变化量,更详细地说,每个计算周期的变化量大于预定的空燃比变化判定值的条件。
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公开(公告)号:US07945202B2
公开(公告)日:2011-05-17
申请号:US12431171
申请日:2009-04-28
申请人: Takenobu Kimura , Yotaro Sato , Hajime Kawakami
发明人: Takenobu Kimura , Yotaro Sato , Hajime Kawakami
IPC分类号: G03G21/00
CPC分类号: G03G21/0035 , G03G2221/0005
摘要: An cleaning apparatus includes: a first brush roll for removing toner from an image carrier; a second brush roll for removing the toner from the image carrier; a first recovery device for recovering the toner deposited on the first brush roll; a second recovery device for recovering the toner deposited on the second brush roll; a first electric field forming device for forming an electric field between the first brush roll and the image carrier; and a second electric field forming device for forming an electric field between the second brush roll and image carrier, wherein the first brush roll and the second brush roll each has a plurality of electrically conductive yarns arranged on a conductive core, and a resistance R2 of each of the yarns used in the second brush roll is smaller than 1×107 Ω/cm.
摘要翻译: 清洁装置包括:用于从图像载体去除调色剂的第一刷辊; 用于从图像载体去除调色剂的第二刷辊; 用于回收沉积在第一刷辊上的调色剂的第一回收装置; 用于回收沉积在第二刷辊上的调色剂的第二回收装置; 第一电场形成装置,用于在第一刷辊和图像载体之间形成电场; 以及第二电场形成装置,用于在第二刷辊和图像载体之间形成电场,其中第一刷辊和第二刷辊各自具有布置在导电芯上的多个导电纱线,并且电阻R2 在第二刷辊中使用的每个纱线小于1×107&OHgr / cm。
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