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119 条记录 (耗时 0.022 秒)

    NOVEL CONDENSED PYRIDINE OR CONDENSED PYRIMIDINE DERIVATIVE, AND MEDICINAL AGENT COMPRISING SAME
    7.
    发明申请
    NOVEL CONDENSED PYRIDINE OR CONDENSED PYRIMIDINE DERIVATIVE, AND MEDICINAL AGENT COMPRISING SAME 有权
    新型浓缩的吡啶或稠合的吡啶衍生物，以及包含其的药物

    公开(公告)号：US20130102621A1

    公开(公告)日：2013-04-25

    申请号：US13806940

    申请日：2011-06-24

    申请人： Toshiharu Morimoto ,  Tomoaki Koshizawa ,  Gen Watanabe ,  Tadaaki Ohgiya ,  Nao Yamasaki ,  Noriyuki Inoue

    发明人： Toshiharu Morimoto ,  Tomoaki Koshizawa ,  Gen Watanabe ,  Tadaaki Ohgiya ,  Nao Yamasaki ,  Noriyuki Inoue

    IPC分类号： C07D491/048 ,  C07D487/04 ,  C07D495/04

    CPC分类号： C07D491/048 ,  C07D487/04 ,  C07D495/04

    摘要： The present invention relates to provision of a novel compound that has an activity of promoting insulin secretion from pancreatic β cells and thus is useful as a prophylaxis and/or therapeutic agent for diseases caused by hyperglycemia such as diabetes mellitus, andthe compound represented by the following formula (1): wherein one of A and B represents a nitrogen atom and the other represents a nitrogen atom or CR10, X represents an oxygen atom, a sulfur atom or —(CH2)n-N(R12)—, Y represents an oxygen atom, a sulfur atom or —N(R13)—, and R1 to R9 each represent a hydrogen atom or another substituent, or a salt thereof, or a solvate of the compound or the salt.

    摘要翻译： 本发明涉及提供具有促进胰β细胞胰岛素分泌的活性的新型化合物，因此可用作由高血糖引起的疾病如糖尿病的预防和/或治疗剂，以及由 下式（1）：其中A和B之一表示氮原子，另一个表示氮原子或CR 10，X表示氧原子，硫原子或 - （CH 2）n N（R 12） - ，Y表示氧 原子，硫原子或-N（R 13） - ，并且R 1至R 9各自表示氢原子或其它取代基，或其盐，或化合物或其盐的溶剂合物。

    Electric motor control apparatus
    8.
    发明授权
    Electric motor control apparatus 有权
    电动机控制装置

    公开(公告)号：US07990093B2

    公开(公告)日：2011-08-02

    申请号：US12279859

    申请日：2006-04-20

    申请人： Isao Kezobo ,  Masahiro Kimata ,  Takayuki Kifuku ,  Kazumichi Tsutsumi ,  Chiaki Fujimoto ,  Noriyuki Inoue

    发明人： Isao Kezobo ,  Masahiro Kimata ,  Takayuki Kifuku ,  Kazumichi Tsutsumi ,  Chiaki Fujimoto ,  Noriyuki Inoue

    IPC分类号： H02P7/00

    CPC分类号： B62D5/0487 ,  B62D5/0484 ,  H02P21/00 ,  H02P29/032

    摘要： A control apparatus for a multiphase AC electric motor having an inverter includes a current control including an abnormal-state current controller; an abnormal-state detector that detects an abnormal state of any of a wire of an electric motor, a wire of an inverter, and a wire connecting the electric motor to the inverter as an abnormal phase; and an abnormal phase disconnect. The abnormal phase disconnect disconnects one or more of phases detected to be in an abnormal-state and the abnormal-state current controller generates an abnormal state voltage command in accordance with detection of an abnormal state, and uses phases other than the disconnected phases of the inverter to control individual currents of the phases, with the abnormal-state voltage command used as a multiphase voltage command.

    摘要翻译： 一种具有逆变器的多相交流电动机的控制装置包括：电流控制装置，包括异常电流控制器; 异常状态检测器，其检测电动机的线材，逆变器的线以及将电动机与逆变器连接的线的异常状态，作为异常相位; 和异常相断开。 异常相位断开断开检测到异常状态的一个或多个相位，异常状态电流控制器根据异常状态的检测产生异常状态电压指令，并且使用除 逆变器用于控制各相电流，异常状态电压指令用作多相电压指令。

    PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR HYPERLIPIDEMIA
    9.
    发明申请
    PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR HYPERLIPIDEMIA 有权
    高效药物和/或治疗药物

    公开(公告)号：US20100069433A1

    公开(公告)日：2010-03-18

    申请号：US12593356

    申请日：2008-03-28

    申请人： Toshiaki Takizawa ,  Noriyuki Inoue ,  Katsutoshi Miyosawa

    发明人： Toshiaki Takizawa ,  Noriyuki Inoue ,  Katsutoshi Miyosawa

    IPC分类号： A61K31/47 ,  A61K31/42

    CPC分类号： C07D263/58 ,  A61K31/423 ,  A61K31/47

    摘要： The present invention provides a therapeutic agent for hyperlipidemia having an excellent effect of lowering the cholesterol and triglyceride level in blood plasma.The present invention relates to a prophylactic and/or therapeutic agent for hyperlipidemia, a prophylactic and/or therapeutic agent for obesity or diabetes mellitus, and a prophylactic and/or therapeutic agent for metabolic syndrome, each agent including a compound represented by the following formula (1): , wherein: R1 and R2, which may be identical or different, each represent a hydrogen atom, a methyl group or an ethyl group; R3a, R3b, R4a and R4b, which may be identical or different, each represent a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C1-4 alkyl group, a trifluoromethyl group, a C1-4 alkoxy group, a C1-4 alkylcarbonyloxy group, a di-C1-4 alkylamino group, a C1-4 alkylsulfonyloxy group, a C1-4 alkylsulfonyl group, a C1-4 alkylsulfinyl group, or a C1-4 alkylthio group, or R3a and R3b, or R4a and R4b are joined to represent an alkylenedioxy group; X represents an oxygen atom, a sulfur atom or N—R5 (wherein R5 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylsulfonyl group, or a C1-4 alkyloxycarbonyl group); Y represents an oxygen atom, a S(O)l group (l represents a number from 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, an aminosulfonyl group, or an NH group; Z represents CH or N; n represents a number from 1 to 6; and m represents a number from 2 to 6, or a salt thereof, and a statin, particularly pitavastatin, in combination.

    摘要翻译： 本发明提供了具有降低血浆中胆固醇和甘油三酯水平的优异效果的高脂血症治疗剂。 本发明涉及高脂血症的预防和/或治疗剂，肥胖症或糖尿病的预防和/或治疗剂，以及代谢综合征的预防和/或治疗剂，每种试剂包括由下式表示的化合物 （1）表示：其中：R 1和R 2可以相同或不同，各自表示氢原子，甲基或乙基; R3a，R3b，R4a和R4b可以相同或不同，分别表示氢原子，卤素原子，硝基，羟基，C1-4烷基，三氟甲基，C1-4烷氧基 ，C 1-4烷基羰基氧基，二-C 1-4烷基氨基，C 1-4烷基磺酰氧基，C 1-4烷基磺酰基，C 1-4烷基亚磺酰基或C 1-4烷硫基，或R 3a和R 3b ，或R4a和R4b连接以代表亚烷基二氧基; X表示氧原子，硫原子或N-R5（其中，R5表示氢原子，C1-4烷基，C1-4烷基磺酰基或C1-4烷氧基羰基）。 Y表示氧原子，S（O）1基（l表示0〜2的数），羰基，羰基氨基，氨基羰基，磺酰基氨基，氨基磺酰基或NH基。 Z表示CH或N; n表示1〜6的数; m代表2至6的数，或其盐，他汀类，特别是匹伐他汀组合。