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公开(公告)号：US20100291059A1
公开(公告)日：2010-11-18
申请号：US12600497
申请日：2008-05-19
CPC分类号： C12N9/2465 , A61K38/47 , A61K48/005
摘要： The present invention provides a pharmaceutical composition comprising a protein having α-galactosidase activity for treating Fabry disease, which causes no allergic side effect, which is highly stable in blood (plasma) and which can readily be taken up by a cell of an affected organ. The pharmaceutical composition for treating Fabry disease of the invention comprises, for example, a protein which acquires an α-galactosidase activity through alteration of the structure of the active site of wild-type human α-N-acetylgalactosaminidase.
摘要翻译： 本发明提供一种药物组合物，其包含具有α-半乳糖苷酶活性的蛋白质，用于治疗法布里病，其不引起过敏性副作用，其在血液（血浆）中高度稳定，并且可容易地被受影响器官的细胞摄取 。 用于治疗本发明的法布里病的药物组合物包括例如通过改变野生型人α-N-乙酰半乳糖胺酶的活性位点的结构而获得α-半乳糖苷酶活性的蛋白质。
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公开(公告)号：US08569032B2
公开(公告)日：2013-10-29
申请号：US12600497
申请日：2008-05-19
IPC分类号： C12N9/40
CPC分类号： C12N9/2465 , A61K38/47 , A61K48/005
摘要： The present invention provides a pharmaceutical composition comprising a protein having α-galactosidase activity for treating Fabry disease, which causes no allergic side effect, which is highly stable in blood (plasma) and which can readily be taken up by a cell of an affected organ. The pharmaceutical composition for treating Fabry disease of the invention comprises, for example, a protein which acquires an α-galactosidase activity through alteration of the structure of the active site of wild-type human α-N-acetylgalactosaminidase.
摘要翻译： 本发明提供一种药物组合物，其包含具有用于治疗法布里病的α-半乳糖苷酶活性的蛋白质，其不引起过敏性副作用，其在血液（血浆）中高度稳定并且可容易地被受影响器官的细胞摄取 。 用于治疗本发明的法布里病的药物组合物包括例如通过改变野生型人α-N-乙酰半乳糖胺酶的活性位点的结构获得α-半乳糖苷酶活性的蛋白质。
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公开(公告)号：US08323640B2
公开(公告)日：2012-12-04
申请号：US13052632
申请日：2011-03-21
申请人： Hitoshi Sakuraba , Youichi Tajima , Mai Ito , Seiichi Aikawa , Fumiko Aikawa
发明人： Hitoshi Sakuraba , Youichi Tajima , Mai Ito , Seiichi Aikawa , Fumiko Aikawa
CPC分类号： C12N9/2465 , A61K38/00 , C12N9/2402 , C12Y302/01022 , C12Y302/01049
摘要： The present invention provides, as an enzyme which can be used for enzyme replacement therapy for Fabry disease, a protein having α-galactosidase activity, which shows no allergic adverse side effect, shows a high stability in blood, and can be easily incorporated into a cell of an affected organ. The protein of the present invention is a protein which has acquired α-galactosidase activity by changing the structure of the active site of wild-type human α-N-acetylgalactosaminidase.
摘要翻译： 本发明提供作为法布里病的酶替代疗法的酶，不具有过敏性副作用的具有α-半乳糖苷酶活性的蛋白质在血液中显示高稳定性，并且可以容易地加入到 受影响器官的细胞。 本发明的蛋白质是通过改变野生型人α-N-乙酰半乳糖胺酶活性位点的结构而获得α-半乳糖苷酶活性的蛋白质。
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4.发明申请公开(公告)号：US20110171198A1
公开(公告)日：2011-07-14
申请号：US13052632
申请日：2011-03-21
申请人： Hitoshi Sakuraba , Youichi Tajima , Mai Ito , Seiichi Aikawa , Fumiko Aikawa
发明人： Hitoshi Sakuraba , Youichi Tajima , Mai Ito , Seiichi Aikawa , Fumiko Aikawa
CPC分类号： C12N9/2465 , A61K38/00 , C12N9/2402 , C12Y302/01022 , C12Y302/01049
摘要： The present invention provides, as an enzyme which can be used for enzyme replacement therapy for Fabry disease, a protein having α-galactosidase activity, which shows no allergic adverse side effect, shows a high stability in blood, and can be easily incorporated into a cell of an affected organ. The protein of the present invention is a protein which has acquired α-galactosidase activity by changing the structure of the active site of wild-type human α-N-acetylgalactosaminidase.
摘要翻译： 本发明提供作为法布里病的酶替代疗法的酶，不具有过敏性副作用的具有α-半乳糖苷酶活性的蛋白质在血液中显示高稳定性，并且可以容易地加入到 受影响器官的细胞。 本发明的蛋白质是通过改变野生型人α-N-乙酰半乳糖胺酶活性位点的结构而获得α-半乳糖苷酶活性的蛋白质。
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公开(公告)号：US20100166728A1
公开(公告)日：2010-07-01
申请号：US12084982
申请日：2006-11-17
申请人： Hitoshi Sakuraba , Youichi Tajima , Mai Ito , Seiichi Aikawa , Fumiko Aikawa
发明人： Hitoshi Sakuraba , Youichi Tajima , Mai Ito , Seiichi Aikawa , Fumiko Aikawa
IPC分类号： A61K38/47 , A61P3/00 , A61P13/12 , A61P27/02 , A61P25/00 , A61P9/04 , A61P17/00 , A61P29/00 , C12N9/40 , C12N15/56 , C12N15/63 , C12N5/00
CPC分类号： C12N9/2465 , A61K38/00 , C12N9/2402 , C12Y302/01022 , C12Y302/01049
摘要： The present invention provides, as an enzyme which can be used for enzyme replacement therapy for Fabry disease, a protein having α-galactosidase activity, which shows no allergic adverse side effect, shows a high stability in blood, and can be easily incorporated into a cell of an affected organ. The protein of the present invention is a protein which has acquired α-galactosidase activity by changing the structure of the active site of wild-type human α-N-acetylgalactosaminidase.
摘要翻译： 本发明提供作为法布里病的酶替代疗法的酶，不具有过敏性副作用的具有α-半乳糖苷酶活性的蛋白质在血液中显示高稳定性，并且可以容易地加入到 受影响器官的细胞。 本发明的蛋白质是通过改变野生型人α-N-乙酰半乳糖胺酶活性位点的结构而获得α-半乳糖苷酶活性的蛋白质。
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公开(公告)号：US07935336B2
公开(公告)日：2011-05-03
申请号：US12084982
申请日：2006-11-17
申请人： Hitoshi Sakuraba , Youichi Tajima , Mai Ito , Seiichi Aikawa , Fumiko Aikawa
发明人： Hitoshi Sakuraba , Youichi Tajima , Mai Ito , Seiichi Aikawa , Fumiko Aikawa
CPC分类号： C12N9/2465 , A61K38/00 , C12N9/2402 , C12Y302/01022 , C12Y302/01049
摘要： The present invention provides, as an enzyme which can be used for enzyme replacement therapy for Fabry disease, a protein having α-galactosidase activity, which shows no allergic adverse side effect, shows a high stability in blood, and can be easily incorporated into a cell of an affected organ. The protein of the present invention is a protein which has acquired α-galactosidase activity by changing the structure of the active site of wild-type human α-N-acetylgalactosaminidase.
摘要翻译： 本发明提供作为法布里病的酶替代疗法的酶，不具有过敏性副作用的具有α-半乳糖苷酶活性的蛋白质在血液中显示高稳定性，并且可以容易地加入到 受影响器官的细胞。 本发明的蛋白质是通过改变野生型人α-N-乙酰半乳糖胺酶活性位点的结构而获得α-半乳糖苷酶活性的蛋白质。
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7.发明授权Method and apparatus for extracting and evaluating mutually similar portions in one-dimensional sequences in molecules and/or three-dimensional structures of molecules 失效用于在分子和/或分子的三维结构中的一维序列中提取和评估相互相似部分的方法和装置公开(公告)号：US06370479B1
公开(公告)日：2002-04-09
申请号：US08014867
申请日：1993-02-08
IPC分类号： G06F1900
摘要： In the analysis of one-dimensional sequences of molecules, the longest common subsequence, the number of elements constituting the subsequence, and appearance positions of the subsequence are determined by a novel and simple method, and processes, such as homology decision, homology search, motif search and alignment are performed based on the results. In the analysis of these-dimensional structures of molecules, limiting conditions, such as geometrical arrangements of elements, are introduced to realize the determination of correspondence of three-dimensional structures at high speeds, and whereby it is made possible to achieve such processing as superposed display of three-dimensional structure of molecules, retrieval of three-dimensional structure, and evaluation of functions. Moreover, the molecules are divided into secondary structure that are then related to each other based on spatial similarity among the secondary structures. Furthermore, similarity among the molecules is decided based on a relationship of spatial positions of the corresponding secondary structures.
摘要翻译： 在分子的一维序列分析中，最长的共同子序列，构成亚序列的元件数量和子序列的出现位置通过新颖简单的方法确定，并且进行诸如同源性决定，同源性检索， 基于结果执行图案搜索和对齐。 在对分子的这些维度结构的分析中，引入限制条件，例如元件的几何布置，以实现高速度下三维结构的对应关系的确定，从而可以实现叠加 显示分子的三维结构，检索三维结构，并评估功能。 此外，基于二级结构之间的空间相似性，将分子分成二级结构，然后彼此相关。 此外，基于相应的二级结构的空间位置的关系来确定分子之间的相似性。
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公开(公告)号：US06453064B1
公开(公告)日：2002-09-17
申请号：US08390862
申请日：1995-02-17
IPC分类号： G06K900
CPC分类号： G06K9/00 , G06K9/6211
摘要： The invention provides an apparatus for extracting a common structure from two three-dimensional structures each formed from a set of sequenced points. The apparatus is constructed so as to extract one of common portions with which the common portion length of the two point sets superposed with each other exhibits a greatest length and the cumulative sum of distances between matched points of the two point sets superposed with each other exhibits a lowest value as an optimum common structure. The common structure extraction apparatus is suitably used to analyze a molecular structure to make clear a mechanism for manifestation of a function of a substance in order to investigate a property of a novel substance such as a protein or artificially produce a novel substance in the fields of physics, chemistry and so forth.
摘要翻译： 本发明提供一种用于从由一组排序点形成的两个三维结构中提取公共结构的装置。 该装置被构造成提取一个共同部分，其中两个点集合的公共部分长度彼此叠加显示最大长度，并且彼此重叠的两个点集合的匹配点之间的距离的累积和表现出 作为最佳共同结构的最低值。 共同结构提取装置适用于分析分子结构，以清楚显示物质功能的机制，以便研究诸如蛋白质之类的新物质的性质或人工产生新物质的性质 物理，化学等。
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公开(公告)号：US6125332A
公开(公告)日：2000-09-26
申请号：US620289
申请日：1996-03-22
CPC分类号： G06T11/206 , G06F19/26 , G06F19/16
摘要： A method and a device for displaying a structure of a compound provide a graphic display and a related character display, affording improved operational characteristics. Stereo structural data obtained from a database is stored in a display buffer provided with a designated area for setting a display mode, thereby displaying graphically a stereo structure of said compound corresponding to the display mode set in said designated area and displaying characters representing said structure of said compound corresponding to said display mode set in said designated area.
摘要翻译： 用于显示化合物结构的方法和装置提供图形显示和相关字符显示，提供改进的操作特性。 从数据库获取的立体声结构数据存储在设置有用于设置显示模式的指定区域的显示缓冲器中，从而以图形方式显示对应于在所述指定区域中设置的显示模式的所述化合物的立体结构，并且显示表示所述指定区域的所述结构的字符 所述化合物对应于在所述指定区域中设置的所述显示模式。
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10.发明授权Method and apparatus for extracting and evaluating mutually similar portions in one-dimensional sequences in molecules and/or three-dimensional structures of molecules 失效用于在分子和/或分子的三维结构中的一维序列中提取和评估相互相似部分的方法和装置公开(公告)号：US07386400B2
公开(公告)日：2008-06-10
申请号：US09910054
申请日：2001-07-23
IPC分类号： G06F19/00
摘要： In the analysis of one-dimensional sequences of molecules, the longest common subsequence, the number of elements constituting the subsequence, and appearance positions of the subsequence are determined by a novel and simple method, and processes, such as homology decision, homology search, motif search and alignment are performed based on the results. In the analysis of these-dimensional structures of molecules, limiting conditions, such as geometrical arrangements of elements, are introduced to realize the determination of correspondence of three-dimensional structures at high speeds, and whereby it is made possible to achieve such processing as superposed display of three-dimensional structure of molecules, retrieval of three-dimensional structure, and evaluation of functions. Moreover, the molecules are divided into secondary structure that are then related to each other based on spatial similarity among the secondary structures. Furthermore, similarity among the molecules is decided based on a relationship of spatial positions of the corresponding secondary structures.
摘要翻译： 在分子的一维序列分析中，最长的共同子序列，构成亚序列的元件数量和子序列的出现位置由新颖简单的方法确定，并且进行诸如同源性决定，同源性检索， 基于结果执行图案搜索和对齐。 在对分子的这些维度结构的分析中，引入限制条件，例如元件的几何布置，以实现高速度下三维结构的对应关系的确定，从而可以实现叠加 显示分子的三维结构，检索三维结构，并评估功能。 此外，基于二级结构之间的空间相似性，将分子分成二级结构，然后彼此相关。 此外，基于相应的二级结构的空间位置的关系来确定分子之间的相似性。
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