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公开(公告)号：US11639394B2
公开(公告)日：2023-05-02
申请号：US16581756
申请日：2019-09-25
Applicant: Hoffmann-La Roche Inc.
Inventor： Sandra Grau-Richards , Christian Klein , Pablo Umaña , Maria Amann , Laurene Pousse
Abstract: The invention relates to bispecific antigen binding molecules comprising (a) at least one moiety capable of specific binding to OX40, and (b) at least one moiety capable of specific binding to epithelial cell adhesion molecule (EpCAM), and to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US11536716B2
公开(公告)日：2022-12-27
申请号：US15745666
申请日：2016-06-21
Applicant: Hoffmann-La Roche Inc.
Inventor： Rosmarie Albrecht , Maria Amann , Christina Claus , Sandra Grau-Richards , Joerg Zielonka
IPC: G01N33/542 , G01N33/68 , G01N33/50
Abstract: The present invention relates to a new cell based assay for combined determination of antibody or ligand binding and function in the same vial.
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公开(公告)号：US20250101135A1
公开(公告)日：2025-03-27
申请号：US18739171
申请日：2024-06-10
Applicant: Hoffmann-La Roche Inc.
Inventor： Maria Amann , Peter Bruenker , Christina Claus , Claudia Ferrara Koller , Sandra Grau-Richards , Christian Klein , Viktor Levitski , Ekkehard Moessner , Joerg Regula , Pablo Umana
IPC: C07K16/40 , A61K38/00 , A61K39/395 , C07K14/705 , C07K16/28 , C07K16/30
Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.
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4.发明授权公开(公告)号：US11149083B2
公开(公告)日：2021-10-19
申请号：US16186443
申请日：2018-11-09
Applicant: Hoffmann—La Roche Inc.
Inventor： Maria Amann , Peter Bruenker , Christina Claus , Claudia Ferrara Koller , Sandra Grau-Richards , Christian Klein , Viktor Levitski , Ekkehard Moessner , Pablo Umana
IPC: C07K16/18 , A61K47/65 , A61P35/00 , C07K14/525 , A61K47/68 , C07K14/715 , C07K16/24
Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one antigen binding moiety capable of specific binding to Tenascin-C (TnC) and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, wherein the antigen binding molecules are characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or two fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof. The invention further relates to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US20200270321A1
公开(公告)日：2020-08-27
申请号：US16653652
申请日：2019-10-15
Applicant: Hoffmann-La Roche Inc.
Inventor： Maria Amann , Peter Bruenker , Christina Claus , Claudia Ferrara Koller , Sandra Grau-Richards , Christian Klein , Viktor Levitski , Ekkehard Moessner , Pablo Umana
IPC: C07K14/525 , C07K16/40 , C07K16/28 , C07K14/705 , C07K16/30 , A61K39/395
Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) a polypeptide comprising three ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by peptide linkers and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.
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Patent Agency Ranking
公开(公告)号：US20190016771A1
公开(公告)日：2019-01-17
申请号：US16144687
申请日：2018-09-27
Applicant: Hoffmann-La Roche Inc.
Inventor： Maria AMANN , Peter Bruenker , Christina Claus , Claudia Ferrara Koller , Sandra Grau-Richards , Christian Klein , Viktor Levitski , Ekkehard Moessner , Pablo Umana
Abstract: The invention relates to novel trimeric costimulatory TNF family ligand-containing antigen binding molecules comprising three fusion polypeptides, each of the three fusion polypeptides comprising (a) an ectodomain of a costimulatory TNF family ligand selected from the group consisting of 4-1BBL, OX40L and GITRL or fragments thereof, (b) a trimerization domain, in particular a trimerization domain derived from human cartilage matrix protein (huCMP) of SEQ ID NO:1, and (c) a moiety capable of specific binding to a target cell antigen, and to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US12227594B2
公开(公告)日：2025-02-18
申请号：US16760820
申请日：2018-10-31
Applicant: Hoffmann-La Roche Inc.
Inventor： Maria Amann , Claudia Ferrara Koller , Reto Flury , Guy Georges , Sandra Grau-Richards , Alexander Haas , Friederike Hesse , Sabine Imhof-Jung , Christian Klein
Abstract: The invention relates to novel bispecific antibodies consisting of two fusion polypeptides comprising two antigen binding domains capable of specific binding to a first target and one antigen binding domain capable of specific binding to a second target, and to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US20220259327A1
公开(公告)日：2022-08-18
申请号：US17580980
申请日：2022-01-21
Applicant: Hoffmann-La Roche Inc.
Inventor： Maria Amann , Peter Bruenker , Christina Claus , Claudia Ferrara Koller , Sandra Grau-Richards , Christian Klein , Viktor Levitski , Ekkehard Moessner , Joerg Thomas Regula , Pablo Umana
IPC: C07K16/40 , C07K16/28 , C07K14/705 , A61K39/395 , C07K16/30
Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.
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公开(公告)号：US20220259326A1
公开(公告)日：2022-08-18
申请号：US17580970
申请日：2022-01-21
Applicant: Hoffmann-La Roche Inc.
Inventor： Maria Amann , Peter Bruenker , Christina Claus , Claudia Ferrara Koller , Sandra Grau-Richards , Christian Klein , Viktor Levitski , Ekkehard Moessner , Joerg Thomas Regula , Pablo Umana
IPC: C07K16/40 , C07K16/28 , C07K14/705 , A61K39/395 , C07K16/30
Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.
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公开(公告)号：US10392445B2
公开(公告)日：2019-08-27
申请号：US15067024
申请日：2016-03-10
Applicant: Hoffmann-La Roche Inc.
Inventor： Maria Amann , Peter Bruenker , Christina Claus , Claudia Ferrara Koller , Sandra Grau-Richards , Christian Klein , Viktor Levitski , Ekkehard Moessner , Joerg Thomas Regula , Pablo Umana
IPC: C07K16/40 , C07K16/28 , C07K14/705 , A61K39/395 , C07K16/30 , A61K38/00
Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.
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