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公开(公告)号:US11780919B2
公开(公告)日:2023-10-10
申请号:US17218948
申请日:2021-03-31
发明人: Maria Amann , Juergen Peter Bachl , Alexander Bujotzek , Carina Cantrill , Harald Duerr , Janine Faigle , Sabine Imhof-Jung , Christian Klein , Thomas Kraft , Estelle Marrer-Berger , Ekkehard Moessner , Laurene Pousse , Petra Rueger , Johannes Sam , Roland Staack , Dietrich Tuerck , Pablo Umana , Joerg Zielonka
CPC分类号: C07K16/2809 , A61K45/06 , A61P35/00 , C07K16/2878 , C07K16/30 , C07K16/468 , A61K2039/505 , C07K2317/565 , C07K2317/622
摘要: The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.
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公开(公告)号:US11536716B2
公开(公告)日:2022-12-27
申请号:US15745666
申请日:2016-06-21
IPC分类号: G01N33/542 , G01N33/68 , G01N33/50
摘要: The present invention relates to a new cell based assay for combined determination of antibody or ligand binding and function in the same vial.
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公开(公告)号:US11242396B2
公开(公告)日:2022-02-08
申请号:US16588780
申请日:2019-09-30
发明人: Peter Bruenker , Harald Duerr , Christian Klein , Pablo Umana , Alexander Bujotzek , Joerg Zielonka , Christine Trumpfheller , Moritz Rapp , Marine Le Clech
摘要: The invention relates to novel bispecific antigen binding molecules, comprising (a) at least one antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP) comprising FAP clone 212 or variants thereof, and (b) at least one antigen binding domain capable of specific binding to CD40, and to methods of producing these molecules and to methods of using the same.
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