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公开(公告)号：US11091471B2
公开(公告)日：2021-08-17
申请号：US16432584
申请日：2019-06-05
发明人： Bernd Buettelmann , Giuseppe Cecere , Bernhard Fasching , Katrin Groebke Zbinden , Maria-Clemencia Hernandez , Henner Knust , Andreas Koblet , Emmanuel Pinard , Andrew Thomas
IPC分类号： C07D413/14 , A61P25/28 , C07D471/04 , C07D487/10
摘要： Compounds having the formula (I) wherein R1, R2, R3, R4, R5, R6, X, Y and Z are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US10239876B2
公开(公告)日：2019-03-26
申请号：US15850826
申请日：2017-12-21
发明人： Bernd Buettelmann , Buelent Kocer , Bernd Kuhn , Marco Prunotto , Hans Richter , Martin Ritter , Markus Rudolph , Alexander Lee Satz
IPC分类号： C07D471/10 , C07D519/00 , A61P1/16 , A61P9/00 , A61P37/06 , A61P13/12 , A61P35/00
摘要： The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein L and R1 to R5 are as described herein, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
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公开(公告)号：US10435407B2
公开(公告)日：2019-10-08
申请号：US16266782
申请日：2019-02-04
发明人： Bernd Buettelmann , Buelent Kocer , Bernd Kuhn , Marco Prunotto , Hans Richter , Martin Ritter , Markus Rudolph , Alexander Lee Satz
IPC分类号： C07D471/10 , A61P35/00 , A61P13/12 , A61P37/06 , A61P9/00 , A61P1/16 , C07D519/00
摘要： The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein L and R1 to R5 are as described herein, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
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公开(公告)号：US09708340B2
公开(公告)日：2017-07-18
申请号：US14856325
申请日：2015-09-16
发明人： Bernd Buettelmann , Simona M. Ceccarelli , Aurelia Conte , Holger Kuehne , Bernd Kuhn , Werner Neidhart , Ulrike Obst Sander , Hans Richter
IPC分类号： C07D211/00 , C07D295/00 , A61K31/445 , C07D495/04 , C07D213/79 , C07D401/12 , C07D409/12 , C07D205/04 , C07D207/16 , C07D277/06 , C07D209/52 , C07D211/60
CPC分类号： C07D495/04 , C07D205/04 , C07D207/16 , C07D209/52 , C07D211/60 , C07D213/79 , C07D277/06 , C07D401/12 , C07D409/12
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, W, A and B are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US09656971B2
公开(公告)日：2017-05-23
申请号：US14752177
申请日：2015-06-26
发明人： Caterina Bissantz , René Bonnafous , Bernd Buettelmann , Roland Jakob-Roetne , Christian Lerner , Markus Rudolph
IPC分类号： C07D239/88 , C07D471/04 , C07D417/10 , C07D417/04 , C07D413/04 , C07D409/04 , C07D409/06 , C07D409/14 , C07D405/04 , C07D403/04 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D401/06
CPC分类号： C07D239/88 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/10 , C07D471/04
摘要： The present invention relates to compounds of formula wherein the substituents are described in claim 1 and to the pharmaceutically acceptable salts thereof. These compounds inhibit the enzyme catechol-O-methyltransferase (COMT). The compounds may be used for the treatment of Parkinson's disease, depression, cognitive impairment and motor symptoms, resistant depression, cognitive impairment, mood and negative symptoms of schizophrenia.
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公开(公告)号：US09604977B2
公开(公告)日：2017-03-28
申请号：US14574950
申请日：2014-12-18
发明人： Bernd Buettelmann , Simona M. Ceccarelli , Holger Kuehne , Bernd Kuhn , Werner Neidhart , Ulrike Obst Sander , Hans Richter
IPC分类号： C07D333/50 , C07D333/66 , C07D417/04 , C07D413/14 , C07D409/04 , C07D409/14 , C07D417/14 , C07D495/04 , C07D495/10 , C07D413/04
CPC分类号： C07D417/04 , C07D333/50 , C07D333/66 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D495/04 , C07D495/10
摘要： Compounds having the formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A, E and n are as described herein, compositions including the compounds and methods of using the compounds as fatty-acid binding protein (FABP) 4 and/or 5 inhibitors for the treatment or prophylaxis of type 2 diabetes, atherosclerosis, chronic kidney diseases, non-alcoholic steatohepatitis and cancer.
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公开(公告)号：US09353102B2
公开(公告)日：2016-05-31
申请号：US14645012
申请日：2015-03-11
发明人： Bernd Buettelmann , Simona M. Ceccarelli , Holger Kuehne , Bernd Kuhn , Werner Neidhart , Ulrike Obst Sander , Hans Richter
IPC分类号： C07D417/04 , C07D417/14 , C07D413/04 , C07D413/14 , C07D333/36
CPC分类号： C07D417/14 , C07D333/36 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A, E and n are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，A，E和n如本文所述，包括该化合物的组合物和使用该化合物的方法。
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公开(公告)号：US09073908B2
公开(公告)日：2015-07-07
申请号：US13916317
申请日：2013-06-12
IPC分类号： A61K31/422 , C07D261/08 , C07D413/12 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/08 , C07D491/10
CPC分类号： C07D413/12 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/08 , C07D491/10
摘要： The present invention is concerned with isoxazole-pyridine derivatives of formula I wherein X, R1 to R6 are as described herein. The compounds are active on the GABA A α5 receptor binding site and useful for the treatment of cognitive disorders, such as Alzheimer's disease.
摘要翻译： 本发明涉及式I的异恶唑 - 吡啶衍生物，其中X，R 1至R 6如本文所述。 该化合物对GABA Aα5受体结合位点是有活性的，可用于治疗认知障碍，如阿尔茨海默病。
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公开(公告)号：US20150183778A1
公开(公告)日：2015-07-02
申请号：US14645012
申请日：2015-03-11
发明人： Bernd Buettelmann , Simona M. Ceccarelli , Holger Kuehne , Bernd Kuhn , Werner Neidhart , Ulrike Obst Sander , Hans Richter
IPC分类号： C07D417/14 , C07D413/14 , C07D333/36 , C07D413/04 , C07D417/04
CPC分类号： C07D417/14 , C07D333/36 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A, E and n are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，A，E和n如本文所述，包括该化合物的组合物和使用该化合物的方法。
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公开(公告)号：US20130274468A1
公开(公告)日：2013-10-17
申请号：US13916191
申请日：2013-06-12
IPC分类号： C07D413/14 , C07D417/14 , C07D487/04 , C07D413/12
CPC分类号： C07D413/12 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/08 , C07D491/10
摘要： The present invention is concerned with isoxazole-pyridine derivatives of formula I wherein X, R1 to R6 are as described herein. The compounds are active on the GABA A α5 receptor binding site and useful for the treatment of cognitive disorders, such as Alzheimer's disease.
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