公开(公告)号：US11780919B2

公开(公告)日：2023-10-10

申请号：US17218948

申请日：2021-03-31

申请人： Hoffmann-La Roche Inc.

发明人： Maria Amann ,  Juergen Peter Bachl ,  Alexander Bujotzek ,  Carina Cantrill ,  Harald Duerr ,  Janine Faigle ,  Sabine Imhof-Jung ,  Christian Klein ,  Thomas Kraft ,  Estelle Marrer-Berger ,  Ekkehard Moessner ,  Laurene Pousse ,  Petra Rueger ,  Johannes Sam ,  Roland Staack ,  Dietrich Tuerck ,  Pablo Umana ,  Joerg Zielonka

IPC分类号： A61K39/00 ,  C07K16/28 ,  A61P35/00 ,  A61K45/06 ,  C07K16/30 ,  C07K16/46

CPC分类号： C07K16/2809 ,  A61K45/06 ,  A61P35/00 ,  C07K16/2878 ,  C07K16/30 ,  C07K16/468 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/622

摘要： The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.