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公开(公告)号：US20110287443A1
公开(公告)日：2011-11-24
申请号：US13073955
申请日：2011-03-28
IPC分类号： G01N33/53 , C07K14/195 , C12P21/00
CPC分类号： C12N9/1051 , C07K14/21 , C07K14/235 , C07K14/28 , C07K14/34 , C07K2319/036 , C12N9/1077 , C12N15/78 , C12P21/00 , C12P21/02 , C12Y204/01 , C12Y204/02036 , C12Y304/24068 , G01N33/573
摘要： The present invention relates to the field of recombinant toxin protein production in bacterial hosts. In particular, the present invention relates to production processes for obtaining high levels of a recombinant CRM197, Diphtheria Toxin, Pertussis Toxin, Tetanus Toxoid Fragment C, Cholera Toxin B, Cholera holotoxin, and Pseudomonas Exotoxin A, from a bacterial host.
摘要翻译： 本发明涉及细菌宿主中重组毒素蛋白质生产领域。 特别地，本发明涉及从细菌宿主获得高水平的重组CRM197，白喉毒素，百日咳毒素，破伤风毒素片段C，霍乱毒素B，霍乱全毒素和假单胞菌外毒素A的生产方法。
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公开(公告)号：US20110245474A1
公开(公告)日：2011-10-06
申请号：US13076315
申请日：2011-03-30
申请人： Hongfan Jin , Lawrence Chew
发明人： Hongfan Jin , Lawrence Chew
IPC分类号： C07K14/535 , C12P21/00
CPC分类号： C07K14/535 , C07K2319/034 , C12P21/02
摘要： The present invention relates to the field of recombinant protein production in bacterial hosts. It further relates to expression of soluble, active recombinant protein by using secretion signals to direct the protein to the periplasmic space of a bacterial cell. In particular, the present invention relates to a production process for obtaining soluble hG-CSF protein from a bacterial host.
摘要翻译： 本发明涉及细菌宿主中重组蛋白质生产领域。 它还涉及通过使用分泌信号将蛋白质引导到细菌细胞的周质空间来表达可溶性活性重组蛋白质。 特别地，本发明涉及从细菌宿主获得可溶性hG-CSF蛋白质的制备方法。
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公开(公告)号：US08530171B2
公开(公告)日：2013-09-10
申请号：US13073955
申请日：2011-03-28
IPC分类号： C07K14/195 , C12P21/00 , G01N33/53
CPC分类号： C12N9/1051 , C07K14/21 , C07K14/235 , C07K14/28 , C07K14/34 , C07K2319/036 , C12N9/1077 , C12N15/78 , C12P21/00 , C12P21/02 , C12Y204/01 , C12Y204/02036 , C12Y304/24068 , G01N33/573
摘要： The present invention relates to the field of recombinant toxin protein production in bacterial hosts. In particular, the present invention relates to production processes for obtaining high levels of a recombinant CRM197, Diphtheria Toxin, Pertussis Toxin, Tetanus Toxoid Fragment C, Cholera Toxin B, Cholera holotoxin, and Pseudomonas Exotoxin A, from a bacterial host.
摘要翻译： 本发明涉及细菌宿主中重组毒素蛋白质生产领域。 特别地，本发明涉及从细菌宿主获得高水平的重组CRM197，白喉毒素，百日咳毒素，破伤风毒素片段C，霍乱毒素B，霍乱全毒素和假单胞菌外毒素A的生产方法。
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公开(公告)号：US08455218B2
公开(公告)日：2013-06-04
申请号：US13076315
申请日：2011-03-30
申请人： Hongfan Jin , Lawrence Chew
发明人： Hongfan Jin , Lawrence Chew
CPC分类号： C07K14/535 , C07K2319/034 , C12P21/02
摘要： The present invention relates to the field of recombinant protein production in bacterial hosts. It further relates to expression of soluble, active recombinant protein by using secretion signals to direct the protein to the periplasmic space of a bacterial cell. In particular, the present invention relates to a production process for obtaining soluble hG-CSF protein from a bacterial host.
摘要翻译： 本发明涉及细菌宿主中重组蛋白质生产领域。 它还涉及通过使用分泌信号将蛋白质引导到细菌细胞的周质空间来表达可溶性活性重组蛋白质。 特别地，本发明涉及从细菌宿主获得可溶性hG-CSF蛋白质的制备方法。
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公开(公告)号：US08603824B2
公开(公告)日：2013-12-10
申请号：US11189375
申请日：2005-07-26
摘要： This invention is a process for improving the production levels of recombinant proteins or peptides or improving the level of active recombinant proteins or peptides expressed in host cells. The invention is a process of comparing two genetic profiles of a cell that expresses a recombinant protein and modifying the cell to change the expression of a gene product that is upregulated in response to the recombinant protein expression. The process can improve protein production or can improve protein quality, for example, by increasing solubility of a recombinant protein.
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公开(公告)号：US20060110747A1
公开(公告)日：2006-05-25
申请号：US11189375
申请日：2005-07-26
申请人： Thomas Ramseier , Hongfan Jin , Charles Squires
发明人： Thomas Ramseier , Hongfan Jin , Charles Squires
摘要： This invention is a process for improving the production levels of recombinant proteins or peptides or improving the level of active recombinant proteins or peptides expressed in host cells. The invention is a process of comparing two genetic profiles of a cell that expresses a recombinant protein and modifying the cell to change the expression of a gene product that is upregulated in response to the recombinant protein expression. The process can improve protein production or can improve protein quality, for example, by increasing solubility of a recombinant protein.
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