公开(公告)号：US20080122287A1

公开(公告)日：2008-05-29

申请号：US11978549

申请日：2007-10-29

申请人： Hongxing Wei ,  David Weber ,  Mark Haller

发明人： Hongxing Wei ,  David Weber ,  Mark Haller

IPC分类号： B60T8/40 ,  B60T15/36 ,  B60T8/36 ,  G06G7/00

CPC分类号： B60T8/4872 ,  B60T8/365 ,  B60T8/368 ,  B60T2270/304

摘要： A method for controlling a vehicle wheel brake that includes applying a pulse width modulated voltage to an isolation valve located between a master brake cylinder and the wheel brake to develop a differential pressure across the isolation valve that is applied to the wheel brake. The differential pressure is a function of the duty cycle of the applied voltage. Because the operation of the isolation valve allows a flow of fluid through the valve, changes in the master cylinder pressure are passed through the isolation valve to the wheel brake.

摘要翻译： 一种用于控制车轮制动器的方法，包括对位于主制动缸和车轮制动器之间的隔离阀施加脉冲宽度调制电压，以跨越施加到车轮制动器的隔离阀产生差压。 压差是施加电压的占空比的函数。 由于隔离阀的操作允许流体流过阀，主缸压力的变化通过隔离阀通过车轮制动。

公开(公告)号：USPP27642P3

公开(公告)日：2017-02-07

申请号：US14121437

申请日：2014-09-08

申请人： David Weber

发明人： David Weber

IPC分类号： A01H5/08

摘要： A new and distinct Vaccinium spp. cultivar named ‘WINTER BELL’ is disclosed, characterized by a semi-upright plant habit, vigorous growth and semi-deciduous habit in Florida. The new variety shows tolerance for wetter soil conditions. Fruit yield is exceptionally high, with fruit ripening early, with first harvest in mid to late March. Fruit is somewhat bell-shaped with good size and an attractive waxy coating. The new variety is a Vaccinium, and is normally used as an ornamental garden or landscape plant.

摘要翻译： 一种新的和不同的牛痘属 披露了名为“冬季贝尔”的品种，其特征在于佛罗里达州的半直立植物习性，旺盛的生长和半脱落习惯。 新品种显示了对湿润土壤条件的耐受性。 果实产量异常高，果实成熟早熟，3月中下旬首次收获。 水果有点钟形，尺寸好，有吸引力的蜡质涂层。 新品种是牛痘，通常用作观赏花园或景观植物。

公开(公告)号：US08722624B2

公开(公告)日：2014-05-13

申请号：US13385642

申请日：2012-02-28

申请人： Scott M Kee ,  Paul I Cook ,  James R Smith ,  Robert Kling ,  Scott A Fowler ,  David Weber

发明人： Scott M Kee ,  Paul I Cook ,  James R Smith ,  Robert Kling ,  Scott A Fowler ,  David Weber

IPC分类号： A61K38/17

CPC分类号： A61K38/57 ,  A61K9/19 ,  B01D15/327 ,  B01D15/363 ,  C07K14/8125 ,  G01N30/461

摘要： A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

摘要翻译： 提供了从含有AAT的蛋白质混合物如Cohn馏分IV沉淀物中纯化α-1-抗胰蛋白酶（AAT）的流线型方法。 在本发明的方法中，污染蛋白质通过用不影响AAT的还原剂如二硫醇裂解二硫键而不稳定。 然后将不稳定的蛋白质优先吸附在固体蛋白质吸附材料上，而不加入作为沉淀剂的盐。 固体吸附剂与溶液的分离留下直接适用于色谱纯化的纯化AAT溶液，而不需像现有技术方法那样进行广泛的脱盐。 还描述了一种以商业规模提供高产量的药物级AAT的方法。

公开(公告)号：US20140046325A1

公开(公告)日：2014-02-13

申请号：US13569667

申请日：2012-08-08

申请人： David Weber ,  Thomas P. Clement

发明人： David Weber ,  Thomas P. Clement

IPC分类号： A61B18/14

CPC分类号： A61B18/1447 ,  A61B2018/00077 ,  A61B2018/00202 ,  A61B2018/00595 ,  A61B2018/1475

摘要： A disposable device for tissue cauterization, including a generally electrically insulating housing assembly and a generally electrically conducting elongated assembly. The housing assembly includes a barrel having a cylindrical aperture formed therethrough, a grip extending from the barrel, a trigger slidingly connected to the barrel, a spring connected to the trigger, and an end plug positioned adjacent the proximal end of the barrel. The elongated assembly includes a hollow elongated outer cylinder disposed within the barrel and extending from the distal end, a generally hollow elongated inner cylinder slidably disposed within the elongated outer cylinder and extending to snugly engage the end plug, and bipolar forceps operationally connected to the distal end of the elongated inner cylinder and defining a leaf spring. Actuation of the trigger urges the inner cylinder to slide in a proximal direction relative to the outer cylinder, urging the bipolar forceps partially into the outer cylinder and closer together.

摘要翻译： 一种用于组织烧灼的一次性装置，包括通常电绝缘的壳体组件和通常导电的细长组件。 壳体组件包括具有穿过其形成的圆柱形孔的筒，从筒延伸的手柄，滑动地连接到筒的触发器，连接到触发器的弹簧以及邻近筒的近端定位的端塞。 细长组件包括设置在筒内并且从远端延伸的中空细长外筒，大致中空的细长内筒，其可滑动地设置在细长外筒内并延伸以紧密地接合端塞，并且双极镊操作地连接到远端 伸长的内筒的端部并限定一个板簧。 触发器的致动促使内筒相对于外筒沿近端方向滑动，将双极钳部分地推入外筒并更靠近在一起。

公开(公告)号：US08647055B2

公开(公告)日：2014-02-11

申请号：US13064815

申请日：2011-04-18

申请人： Gregory Thomas Foster ,  Robert Coign ,  Kevin McGovern ,  David Weber

发明人： Gregory Thomas Foster ,  Robert Coign ,  Kevin McGovern ,  David Weber

IPC分类号： F01D25/28

CPC分类号： F01D25/246 ,  F01D11/24 ,  F05D2230/64 ,  F05D2240/11 ,  F05D2300/20 ,  F05D2300/21 ,  F05D2300/6033 ,  Y02T50/672

摘要： Shroud assembly for use in a turbine, having an outer shroud having a side proximate to flow of operative fluid of the turbine, the side having a boss and an outer shroud aperture extending through the boss. An inner shroud is located between the side of the outer shroud proximate to the flow of operative fluid and the operative fluid flow of the turbine, the inner shroud having an inner shroud aperture which is dimensioned to fit over the boss.

摘要翻译： 用于涡轮机的护罩组件，其具有外侧护罩，所述外护罩具有靠近所述涡轮机的操作流体流动的一侧，所述侧部具有延伸穿过所述凸台的凸台和外护罩孔。 内护罩位于外护罩的靠近操作流体流动和涡轮机的操作流体流动的侧面之间，内护罩具有内护罩孔口，其尺寸适于安装在凸台上。

公开(公告)号：US08124736B2

公开(公告)日：2012-02-28

申请号：US12855721

申请日：2010-08-13

申请人： Scott M Kee ,  Paul I. Cook ,  James R Smith ,  Robert Kling ,  Scott A Fowler ,  David Weber

发明人： Scott M Kee ,  Paul I. Cook ,  James R Smith ,  Robert Kling ,  Scott A Fowler ,  David Weber

IPC分类号： A61K35/14

CPC分类号： A61K38/57 ,  A61K9/19 ,  B01D15/327 ,  B01D15/363 ,  C07K14/8125 ,  G01N30/461

摘要： A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

公开(公告)号：US20070123363A1

公开(公告)日：2007-05-31

申请号：US11564724

申请日：2006-11-29

申请人： David Weber

发明人： David Weber

IPC分类号： A63B69/36 ,  B62J39/00 ,  B62J11/00 ,  B62J7/06

CPC分类号： A63B55/60 ,  A63B55/00 ,  B62H1/02 ,  B62J11/00 ,  B62K2005/002

摘要： Embodiments of the present invention comprise a system for carrying golf clubs on the front end of a bicycle by dividing the clubs between two enclosures: one to the left of the bicycle's front fork and one to the right thereof. Another Embodiment comprises the aforementioned system in combination with a bicycle having tires with a diameter in excess of 3.0 inches. The bicycle in combination with the system can be rented to golfers in place of golf carts to transport the golfer around a course.

摘要翻译： 本发明的实施例包括一种用于在自行车的前端承载高尔夫球杆的系统，该球杆在两个机壳之间分开：一个在自行车前叉的左侧和一个右侧。 另一个实施例包括与具有直径超过3.0英寸的轮胎的自行车组合的上述系统。 与系统相结合的自行车可以出租给高尔夫球手代替高尔夫球车，以便将高尔夫球手运送到球场周围。

公开(公告)号：US20060258698A1

公开(公告)日：2006-11-16

申请号：US11351761

申请日：2006-02-09

申请人： Sreenivasu Mudumba ,  Philippe Dor ,  Thierry Nivaggioli ,  David Weber ,  Sidiq Farooq

发明人： Sreenivasu Mudumba ,  Philippe Dor ,  Thierry Nivaggioli ,  David Weber ,  Sidiq Farooq

IPC分类号： A61K31/4745

CPC分类号： A61K9/0046 ,  A61K9/0019 ,  A61K9/0048 ,  A61K31/045 ,  A61K31/436 ,  A61K31/44 ,  A61K31/4745 ,  A61K47/10 ,  A61K47/12 ,  A61K47/44

摘要： Diseases and conditions associated with tissues of the body, including but not limited to tissues in the eye, can be effectively treated, prevented, inhibited, onset delayed, or regression caused by administering therapeutic agents to those tissues. Described herein are liquid formulations which deliver a variety of therapeutic agents, including but not limited to rapamycin, to a subject for an extended period of time; liquid formulations which form a non-dispersed mass when placed in an aqueous medium of a subject; non-dispersed mass-forming liquid formulations which form a gel or gel-like substance in an aqueous medium; liquid formulations, comprising a therapeutic agent and a plurality of polymers; and methods for delivering therapeutic agents to a subject for an extended period of time using the liquid formulations. The liquid formulation may be placed in an aqueous medium of a subject, including but not limited to via intraocular or periocular administration, or placement proximate to a site of a disease or condition to be treated in a subject. A method may be used to administer rapamycin to treat or prevent angiogenesis, choroidal neovascularization, or age-related macular degeneration, or wet age-related macular degeneration in a subject. The liquid formulations may comprise rapamycin or other therapeutic agents.

公开(公告)号：US20060257450A1

公开(公告)日：2006-11-16

申请号：US11386290

申请日：2006-03-21

申请人： Sreenivasu Mudumba ,  Philippe Jm Dor ,  Thierry Nivaggioli ,  David Weber ,  Sidiq Farooq

发明人： Sreenivasu Mudumba ,  Philippe Jm Dor ,  Thierry Nivaggioli ,  David Weber ,  Sidiq Farooq

IPC分类号： A61K31/4745 ,  A61F2/02

CPC分类号： A61K9/0051 ,  A61K31/436 ,  A61K31/4745

摘要： Diseases and conditions associated with tissues of the body, including but not limited to tissues in the eye, can be effectively treated, prevented, inhibited, onset delayed, or regression caused by administering therapeutic agents to those tissues. Described herein are solid drug delivery systems and methods for providing extended delivery of therapeutic agents to such tissues. A solid drug delivery system may be placed in a subject, including but not limited to placement between the sclera and the conjunctiva or transscleral placement. Described methods may be used to administer rapamycin to treat or prevent angiogenesis, choroidal neovascularization, age-related macular degeneration, or wet age-related macular degeneration in a subject. The solid drug delivery devices may comprise rapamycin or other therapeutic agents. Also described are methods of treating ocular diseases or disorders by administering an antiproliferative agent, including but not limited to rapamycin, proximal to an ocular device.

摘要翻译： 包括但不限于眼睛中的组织的疾病和病症可被有效治疗，预防，抑制，发作延迟或由给予这些组织的治疗剂引起的回归。 本文描述的是用于向这些组织提供治疗剂的延长递送的固体药物递送系统和方法。 固体药物递送系统可以放置在受试者中，包括但不限于在巩膜和结膜之间的放置或经巩膜​​放置。 描述的方法可用于施用雷帕霉素以治疗或预防受试者的血管生成，脉络膜新生血管形成，年龄相关性黄斑变性或湿性年龄相关性黄斑变性。 固体药物递送装置可以包含雷帕霉素或其它治疗剂。 还描述了通过在近视眼装置上施用抗增生剂（包括但不限于雷帕霉素）来治疗眼部疾病或病症的方法。

公开(公告)号：US20050007202A1

公开(公告)日：2005-01-13

申请号：US10839779

申请日：2004-05-04

申请人： David Su ,  Chik Yue ,  David Weber ,  Masoud Zargari

发明人： David Su ,  Chik Yue ,  David Weber ,  Masoud Zargari

IPC分类号： H03K23/66 ,  H03L7/089 ,  H03L7/095 ,  H03L7/099 ,  H03L7/10 ,  H03L7/183 ,  H03L7/193 ,  H03L7/00

CPC分类号： H03L7/099 ,  H03K23/667 ,  H03L7/089 ,  H03L7/095 ,  H03L7/10 ,  H03L7/193 ,  Y10S331/02

摘要： The present invention provides a synthesizer having an efficient lock detect signal generator, an extended range VCO that can operate within any one of a plurality of adjacent characteristic curves defined by a plurality of adjacent regions, and a divide circuit implemented using only a single counter along with a decoder. This allows for a method of operating the synthesizer, methods of establishing or reestablishing a lock condition using the extended range VCO, and a method of designing a plurality of divide circuits which each use the same single counter and each use a different decoder.

摘要翻译： 本发明提供一种合成器，其具有有效的锁定检测信号发生器，能够在由多个相邻区域限定的多个相邻特性曲线中的任何一个中操作的扩展范围VCO，以及仅使用单个计数器实现的除法电路 与解码器。 这允许操作合成器的方法，使用扩展范围VCO建立或重新建立锁定条件的方法，以及设计多个除法电路的方法，每个除法电路使用相同的单个计数器并且每个使用不同的解码器。