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1.发明授权System for characterizing patient tissue impedance for monitoring and treatment 有权用于表征患者组织阻抗的系统用于监测和治疗公开(公告)号：US08157848B2
公开(公告)日：2012-04-17
申请号：US12356901
申请日：2009-01-21
IPC分类号： A61N1/00
CPC分类号： A61B5/053 , A61B5/0422 , A61B5/6858 , A61B5/7217
摘要： A system provides early prediction of heart tissue malfunction and electrophysiological pathology by determining anatomical tissue impedance characteristics for use in medical patient monitoring and treatment decision making. At least one repository of data indicates multiple predetermined expected impedance value ranges for corresponding multiple impedance measurements taken at multiple particular different sites of at least one anatomical organ. An impedance measurement processor automatically determines whether multiple measured impedance values taken at multiple particular different sites of an anatomical organ using an invasive catheter are within corresponding multiple predetermined expected impedance value ranges derived from the at least one repository. An output processor automatically communicates data comprising at least one message to a destination. The at least one message includes data indicating whether the multiple measured impedance values taken at the multiple particular different sites of the anatomical organ are within the corresponding multiple predetermined expected impedance value ranges.
摘要翻译： 系统通过确定用于医疗患者监测和治疗决策的解剖组织阻抗特征来提供对心脏组织功能障碍和电生理病理学的早期预测。 至少一个数据库指示在至少一个解剖器官的多个特定不同位置处进行的对应的多个阻抗测量值的多个预定的阻抗值范围。 阻抗测量处理器自动地确定在使用侵入性导管的解剖器官的多个特定不同位置处采集的多个测量阻抗值是否在从至少一个储存库导出的相应的多个预定预期阻抗值范围内。 输出处理器自动将包含至少一个消息的数据传送到目的地。 所述至少一个消息包括指示在解剖器官的多个特定不同位置处取得的多个测量阻抗值是否在相应的多个预定的预期阻抗值范围内的数据。
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公开(公告)号：US20120016251A1
公开(公告)日：2012-01-19
申请号：US13042806
申请日：2011-03-08
IPC分类号： A61B5/08
CPC分类号： A61B5/0402 , A61B5/082 , A61B5/0836 , A61B5/14503 , A61B5/14542 , A61B5/14551 , A61B5/1459 , A61B5/4836 , A61B5/7267 , A61N1/36514 , A61N1/36557 , A61N1/36564 , A61N1/36585 , G16H50/20
摘要： A system for respiration or cardiac condition characterization and abnormality detection includes an interface that receives data representing a signal indicating concentration of carbon dioxide in patient gases over multiple signal cycles. A signal processor uses the received data in determining multiple amplitude related characteristic values. A comparator compares at least one of the amplitude related characteristic values or a value derived from the amplitude related characteristic values, with a threshold value to provide a comparison indicator. A patient monitor in response to the comparison indicator indicating an amplitude related characteristic value or a value derived from the amplitude related characteristic values, exceeds the threshold value, generates an alert message associated with the threshold.
摘要翻译： 用于呼吸或心脏状况表征和异常检测的系统包括接收表示在多个信号周期中表示患者气体中的二氧化碳浓度的信号的数据。 信号处理器使用所接收的数据来确定多个幅度相关的特征值。 比较器将幅度相关特征值中的至少一个或从幅度相关特征值导出的值与阈值进行比较，以提供比较指示符。 响应于指示幅度相关特征值的比较指示器或从幅度相关特征值导出的值的患者监视器超过阈值，生成与阈值相关联的警报消息。
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3.发明申请System for Characterizing Patient Tissue Impedance for Monitoring and Treatment 有权用于表征患者组织阻抗进行监测和治疗的系统公开(公告)号：US20090198300A1
公开(公告)日：2009-08-06
申请号：US12356901
申请日：2009-01-21
IPC分类号： A61N1/00
CPC分类号： A61B5/053 , A61B5/0422 , A61B5/6858 , A61B5/7217
摘要： A system provides early prediction of heart tissue malfunction and electrophysiological pathology by determining anatomical tissue impedance characteristics for use in medical patient monitoring and treatment decision making. At least one repository of data indicates multiple predetermined expected impedance value ranges for corresponding multiple impedance measurements taken at multiple particular different sites of at least one anatomical organ. An impedance measurement processor automatically determines whether multiple measured impedance values taken at multiple particular different sites of an anatomical organ using an invasive catheter are within corresponding multiple predetermined expected impedance value ranges derived from the at least one repository. An output processor automatically communicates data comprising at least one message to a destination. The at least one message includes data indicating whether the multiple measured impedance values taken at the multiple particular different sites of the anatomical organ are within the corresponding multiple predetermined expected impedance value ranges.
摘要翻译： 系统通过确定用于医疗患者监测和治疗决策的解剖组织阻抗特征来提供对心脏组织功能障碍和电生理病理学的早期预测。 至少一个数据库指示在至少一个解剖器官的多个特定不同位置处进行的对应的多个阻抗测量值的多个预定的阻抗值范围。 阻抗测量处理器自动地确定在使用侵入性导管的解剖器官的多个特定不同位置处采集的多个测量阻抗值是否在从至少一个储存库导出的相应的多个预定预期阻抗值范围内。 输出处理器自动将包含至少一个消息的数据传送到目的地。 所述至少一个消息包括指示在解剖器官的多个特定不同位置处取得的多个测量阻抗值是否在相应的多个预定的预期阻抗值范围内的数据。
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公开(公告)号：US20090281441A1
公开(公告)日：2009-11-12
申请号：US12418260
申请日：2009-04-03
IPC分类号： A61B5/0468 , A61N1/365 , A61M37/00
CPC分类号： A61B5/0468 , A61B5/7275 , A61N1/365
摘要： A system for heart performance characterization and abnormality detection includes an acquisition device for acquiring an electrophysiological signal representing heart beat cycles of a patient heart. A detector detects one or more parameters of the electrophysiological signal of parameter type comprising at least one of, (a) amplitude, (b) time duration, (c) peak frequency and (d) frequency bandwidth, of multiple different portions of a single heart beat cycle of the heart beat cycles selected in response to first predetermined data. The multiple different portions of the single heart beat cycle being selected from, a P wave portion, a QRS complex portion, an ST segment portion and a T wave portion in response to second predetermined data. A signal analyzer calculates a ratio of detected parameters of a single parameter type of the multiple different portions of the single heart beat cycle. An output processor generates data representing an alert message in response to a calculated ratio exceeding a predetermined threshold.
摘要翻译： 用于心脏性能表征和异常检测的系统包括用于获取表示患者心脏心跳周期的电生理信号的采集装置。 检测器检测参数类型的电生理信号的一个或多个参数，该参数类型包括以下中的至少一个：（a）单个的多个不同部分的（a）幅度，（b）持续时间，（c）峰值频率和（d） 响应于第一预定数据选择的心搏周期的心搏周期。 响应于第二预定数据，选择单心跳周期的多个不同部分，P波部分，QRS复合部分，ST段部分和T波部分。 信号分析器计算单个心跳周期的多个不同部分的单个参数类型的检测参数的比率。 响应于超过预定阈值的计算比率，输出处理器产生表示警报消息的数据。
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公开(公告)号：US08755875B2
公开(公告)日：2014-06-17
申请号：US12418260
申请日：2009-04-03
IPC分类号： A61B5/0452
CPC分类号： A61B5/0468 , A61B5/7275 , A61N1/365
摘要： A system for heart performance characterization and abnormality detection includes an acquisition device for acquiring an electrophysiological signal representing heart beat cycles of a patient heart. A detector detects one or more parameters of the electrophysiological signal of parameter type comprising at least one of, (a) amplitude, (b) time duration, (c) peak frequency and (d) frequency bandwidth, of multiple different portions of a single heart beat cycle of the heart beat cycles selected in response to first predetermined data. The multiple different portions of the single heart beat cycle being selected from, a P wave portion, a QRS complex portion, an ST segment portion and a T wave portion in response to second predetermined data. A signal analyzer calculates a ratio of detected parameters of a single parameter type of the multiple different portions of the single heart beat cycle. An output processor generates data representing an alert message in response to a calculated ratio exceeding a predetermined threshold.
摘要翻译： 用于心脏性能表征和异常检测的系统包括用于获取表示患者心脏心跳周期的电生理信号的采集装置。 检测器检测参数类型的电生理信号的一个或多个参数，该参数类型包括以下中的至少一个：（a）单个的多个不同部分的（a）幅度，（b）持续时间，（c）峰值频率和（d）频率带宽 响应于第一预定数据选择的心搏周期的心搏周期。 响应于第二预定数据，选择单心跳周期的多个不同部分，P波部分，QRS复合部分，ST段部分和T波部分。 信号分析器计算单个心跳周期的多个不同部分的单个参数类型的检测参数的比率。 响应于超过预定阈值的计算比率，输出处理器产生表示警报消息的数据。
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公开(公告)号：US20090259266A1
公开(公告)日：2009-10-15
申请号：US12391666
申请日：2009-02-24
IPC分类号： A61N1/365 , A61B5/0402 , A61M31/00
CPC分类号： A61B5/0464 , A61B5/0422 , A61B5/04325 , A61B5/0452 , A61B5/7275 , A61N1/37
摘要： A system analyzes and characterizes cardiac electrophysiological signals by determining instantaneous signal entropy for identifying and characterizing cardiac disorders, differentiating cardiac arrhythmias, determining pathological severity and predicting life-threatening events. A system for heart monitoring, characterization and abnormality detection, includes an acquisition device for acquiring an electrophysiological signal representing a heart beat cycle of a patient heart. A signal processor derives an entropy representative value of the acquired electrophysiological signal within a time period comprising at least a portion of a heart beat cycle of the acquired electrophysiological signal and provides an entropy value as a function of the entropy representative value and the time period. A comparator generates data representing a message for communication to a destination device in response to the entropy value exceeding a predetermined threshold.
摘要翻译： 系统通过确定用于识别和表征心脏疾病，区分心律失常，确定病理严重性和预测危及生命的事件的瞬时信号熵来分析和表征心脏电生理信号。 用于心脏监测，表征和异常检测的系统包括用于获取代表患者心脏心跳周期的电生理信号的采集装置。 信号处理器在包括获取的电生理信号的心跳周期的至少一部分的时间段内导出所获取的电生理信号的熵代表值，并提供作为熵代表值和时间段的函数的熵值。 响应于熵值超过预定阈值，比较器产生表示用于与目的地设备通信的消息的数据。
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公开(公告)号：US08929975B2
公开(公告)日：2015-01-06
申请号：US12391666
申请日：2009-02-24
IPC分类号： A61B5/04 , A61B5/02 , A61B5/0464 , A61B5/0452 , A61B5/042 , A61B5/0432 , A61B5/00 , A61N1/37
CPC分类号： A61B5/0464 , A61B5/0422 , A61B5/04325 , A61B5/0452 , A61B5/7275 , A61N1/37
摘要： A system analyzes and characterizes cardiac electrophysiological signals by determining instantaneous signal entropy for identifying and characterizing cardiac disorders, differentiating cardiac arrhythmias, determining pathological severity and predicting life-threatening events. A system for heart monitoring, characterization and abnormality detection, includes an acquisition device for acquiring an electrophysiological signal representing a heart beat cycle of a patient heart. A signal processor derives an entropy representative value of the acquired electrophysiological signal within a time period comprising at least a portion of a heart beat cycle of the acquired electrophysiological signal and provides an entropy value as a function of the entropy representative value and the time period. A comparator generates data representing a message for communication to a destination device in response to the entropy value exceeding a predetermined threshold.
摘要翻译： 系统通过确定用于识别和表征心脏疾病，区分心律失常，确定病理严重性和预测危及生命的事件的瞬时信号熵来分析和表征心脏电生理信号。 用于心脏监测，表征和异常检测的系统包括用于获取代表患者心脏心跳周期的电生理信号的采集装置。 信号处理器在包括获取的电生理信号的心跳周期的至少一部分的时间段内导出所获取的电生理信号的熵代表值，并提供作为熵代表值和时间段的函数的熵值。 响应于熵值超过预定阈值，比较器产生表示用于与目的地设备通信的消息的数据。
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8.发明申请EP SIGNAL MAPPING-BASED OPTICAL ABLATION FOR PATIENT MONITORING AND MEDICAL APPLICATIONS 审中-公开用于患者监测和医学应用的基于信号映射的光学消除公开(公告)号：US20090112199A1
公开(公告)日：2009-04-30
申请号：US12202478
申请日：2008-09-02
IPC分类号： A61B18/24
CPC分类号： A61B18/24 , A61B5/0422 , A61B5/7217 , A61M25/0068 , A61M25/0082 , A61M25/0133 , A61M25/0136
摘要： A system and method are disclosed for utilizing a single integrated EP/ablation catheter to treat cardiac arrhythmias. The disclosed catheter combines the EP signal monitoring of a traditional EP diagnostic catheter, and optical energy for the ablation therapy, which is expected to provide a more efficient, accurate and reliable method of cardiac ablation than current RF techniques since it is based on real-time EP signal mapping, with precise pathological tissue localization, cardiac arrhythmia severity characterization and delivers predictable energy doses with continuous safety monitoring of the intracardiac signals.
摘要翻译： 公开了一种利用单个集成EP /消融导管来治疗心律失常的系统和方法。 所公开的导管结合了传统EP诊断导管的EP信号监测和用于消融治疗的光能，其预期将提供比现有RF技术更有效，准确和可靠的心脏消融方法，因为它基于实时的， 时间EP信号映射，精确的病理组织定位，心律失常严重程度表征，并提供可预测的能量剂量，并持续监测心内信号。
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公开(公告)号：US08200308B2
公开(公告)日：2012-06-12
申请号：US12171421
申请日：2008-07-11
申请人： Hongxuan Zhang , Detlef W. Koertge
发明人： Hongxuan Zhang , Detlef W. Koertge
IPC分类号： A61B5/0215 , A61B5/01 , A61B5/042
CPC分类号： A61B5/01 , A61B5/0422 , A61B18/1492 , A61B2018/00702 , A61B2018/00767 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2562/182
摘要： A catheter has a plurality of sensors and electrodes, wherein the sensors are arranged alternately and spaced apart from each other. A system for continuous measurement and mapping of physiological data may use such a catheter with a coupling unit for insulated coupling of the plurality of sensors with a measurement unit and a mapping unit for mapping values received from the sensors to a predefined matrix.
摘要翻译： 导管具有多个传感器和电极，其中传感器彼此交替布置并间隔开。 用于连续测量和映射生理数据的系统可以使用具有耦合单元的这种导管，用于将多个传感器与测量单元和映射单元绝缘耦合，用于将从传感器接收的值映射到预定矩阵。
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公开(公告)号：US20090024016A1
公开(公告)日：2009-01-22
申请号：US12171421
申请日：2008-07-11
申请人： Hongxuan Zhang , Detlef W. Koertge
发明人： Hongxuan Zhang , Detlef W. Koertge
IPC分类号： A61B5/01 , A61B5/04 , A61B5/0215
CPC分类号： A61B5/01 , A61B5/0422 , A61B18/1492 , A61B2018/00702 , A61B2018/00767 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2562/182
摘要： A catheter has a plurality of sensors and electrodes, wherein the sensors are arranged alternately and spaced apart from each other. A system for continuous measurement and mapping of physiological data may use such a catheter with a coupling unit for insulated coupling of the plurality of sensors with a measurement unit and a mapping unit for mapping values received from the sensors to a predefined matrix.
摘要翻译： 导管具有多个传感器和电极，其中传感器彼此交替布置并间隔开。 用于连续测量和映射生理数据的系统可以使用具有耦合单元的这种导管，用于将多个传感器与测量单元和映射单元绝缘耦合，用于将从传感器接收的值映射到预定矩阵。
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