公开(公告)号：US5514602A

公开(公告)日：1996-05-07

申请号：US22544

申请日：1993-02-25

申请人： Houston G. Brooks, Jr. ,  Chi-Deu Chang ,  Utpal R. Chakraborty ,  Henry A. Graham, Jr. ,  Lloyd L. Hollenbeck, Jr. ,  Sharon R. Lawler ,  Jennifer Nasser ,  Ernest G. Schutt ,  Albert Venturini

发明人： Houston G. Brooks, Jr. ,  Chi-Deu Chang ,  Utpal R. Chakraborty ,  Henry A. Graham, Jr. ,  Lloyd L. Hollenbeck, Jr. ,  Sharon R. Lawler ,  Jennifer Nasser ,  Ernest G. Schutt ,  Albert Venturini

IPC分类号： B01J13/00 ,  G01N33/543 ,  G01N33/558 ,  G01N33/58 ,  G01N33/74 ,  G01N33/553

CPC分类号： G01N33/587 ,  B01J13/0004 ,  B01J13/0043 ,  G01N33/54326 ,  G01N33/54386 ,  G01N33/558 ,  G01N33/74 ,  Y10S435/975

摘要： A method and test kit useful in a wide variety of immunoassay systems. A method of producing metal sol reagents containing metal sol particles of a preselected size is provided. A metal containing solution is reduced under optimized pH conditions to produce metal sol particles of a preselected size, the particles are coated with a coupling compound and then bound with at least one selected immunochemically reactive component. Particles having different immunochemical specificities are also mixed to produce reagents having multiple selected immunochemical specificities.

摘要翻译： 用于各种免疫测定系统的方法和测试试剂盒。 提供一种制备含有预选尺寸的金属溶胶颗粒的金属溶胶试剂的方法。 在优化的pH条件下还原含金属溶液以制备预选尺寸的金属溶胶颗粒，用偶联化合物涂覆颗粒，然后与至少一种选择的免疫化学反应性组分结合。 具有不同免疫化学特异性的颗粒也混合以产生具有多种选择的免疫化学特异性的试剂。

公开(公告)号：US5571726A

公开(公告)日：1996-11-05

申请号：US446533

申请日：1995-05-19

申请人： Houston G. Brooks, Jr. ,  Chi-Deu Chang ,  Utpal R. Chakraborty ,  Henry A. Graham, Jr. ,  Lloyd L. Hollenbeck, Jr. ,  Sharon R. Lawler ,  Jennifer Nasser ,  Ernest G. Schutt ,  Albert Venturini

发明人： Houston G. Brooks, Jr. ,  Chi-Deu Chang ,  Utpal R. Chakraborty ,  Henry A. Graham, Jr. ,  Lloyd L. Hollenbeck, Jr. ,  Sharon R. Lawler ,  Jennifer Nasser ,  Ernest G. Schutt ,  Albert Venturini

IPC分类号： B01J13/00 ,  G01N33/543 ,  G01N33/558 ,  G01N33/58 ,  G01N33/74 ,  G01N33/551 ,  G01N33/553

CPC分类号： G01N33/587 ,  B01J13/0004 ,  B01J13/0043 ,  G01N33/54326 ,  G01N33/54386 ,  G01N33/558 ,  G01N33/74 ,  Y10S435/975

摘要： A method and test kit useful in a wide variety of immunoassay systems. A method of producing metal sol reagents containing metal sol particles of a preselected size is provided. A metal containing solution is reduced under optimized pH conditions to produce metal sol particles of a preselected size, the particles are coated with a coupling compound and then bound with at least one selected immunochemically reactive component. Particles having different immunochemical specificities are also mixed to produce reagents having multiple selected immunochemical specificities.

摘要翻译： 用于各种免疫测定系统的方法和测试试剂盒。 提供一种制备含有预选尺寸的金属溶胶颗粒的金属溶胶试剂的方法。 在优化的pH条件下还原含金属溶液以制备预选尺寸的金属溶胶颗粒，用偶联化合物涂覆颗粒，然后与至少一种选择的免疫化学反应性组分结合。 具有不同免疫化学特异性的颗粒也混合以产生具有多种选择的免疫化学特异性的试剂。