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公开(公告)号：US20110318727A1
公开(公告)日：2011-12-29
申请号：US13126081
申请日：2009-10-26
CPC分类号： C12Q1/708 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： The invention provides compositions and methods for the differential detection of high risk forms of HPV from a urine sample provided by a patient. Specifically, the invention provides primers and probes that specifically recognize and bind sequences within the E1 gene of HPV. Detection of high risk forms of HPV identify individuals at risk of developing or in the early stages of cervical carcinoma.
摘要翻译： 本发明提供了用于从患者提供的尿样中差异检测HPV的高风险形式的组合物和方法。 具体地说，本发明提供了特异性识别和结合HPV基因E1基因序列的引物和探针。 检测HPV的高风险形式识别患有发展或宫颈癌早期发生危险的个体。
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公开(公告)号：US20090081640A1
公开(公告)日：2009-03-26
申请号：US12229378
申请日：2008-08-22
CPC分类号： C12Q1/6883 , C12Q1/705 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： Described are non-invasive methods of detecting in vivo cell death by measuring levels of ubiquitous and tissue specific miRNA. The method can be applied for detection of pathologies caused or accompanied by cell death, as well as for diagnosis of infectious disease, cytotoxic effects induced by different chemical or physical factors, and the presence of specific fetal abnormalities.
摘要翻译： 描述了通过测量普遍存在和组织特异性miRNA的水平来检测体内细胞死亡的非侵入性方法。 该方法可用于检测引起或伴有细胞死亡的病理学，以及用于诊断感染性疾病，不同化学或物理因素诱导的细胞毒性作用，以及特定胎儿异常的存在。
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公开(公告)号：USRE39920E1
公开(公告)日：2007-11-13
申请号：US10992639
申请日：2004-11-19
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q1/6879 , C12Q1/6883 , C12Q2600/154 , C12Q2600/156 , Y10T436/143333 , C12Q2527/125 , C12Q2525/125
摘要： Described are non-invasive methods of detecting the presence of specific nucleic acid sequences as well as nucleic acid modifications and alterations by analyzing urine samples for the presence of transrenal nucleic acids. More specifically, the present invention encompasses methods of detecting specific fetal nucleic acid sequences and fetal sequences that contained modified nucleotides by analyzing maternal urine for the presence of fetal nucleic acids. The invention further encompasses methods of detecting specific nucleic acid modifications for the diagnosis of disease, such as cancer and pathogen infections, and detection of genetic predisposition to various disease. The invention specifically encompasses methods of analyzing specific nucleic acid modifications for the monitoring of cancer treatment. The invention further encompasses methods of analyzing specific nucleic acids in urine to track the success of transplanted cells, tissues and organs. The invention also encompasses methods for evaluating the effects of environmental factors and aging on the genome.
摘要翻译： 描述了通过分析尿液样品来检测特定核酸序列的存在以及核酸修饰和改变的非侵入性方法，用于存在跨肾脏核酸。 更具体地，本发明包括通过分析胎儿核酸存在的母体尿来检测含有修饰的核苷酸的特定胎儿核酸序列和胎儿序列的方法。 本发明还包括检测用于诊断疾病如癌症和病原体感染的特异性核酸修饰以及检测各种疾病的遗传易感性的方法。 本发明具体包括分析用于监测癌症治疗的特异性核酸修饰的方法。 本发明还包括分析尿中的特定核酸以追踪移植细胞，组织和器官的成功的方法。 本发明还包括评估环境因素和老化对基因组的影响的方法。
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公开(公告)号：US06251638B1
公开(公告)日：2001-06-26
申请号：US09230704
申请日：2000-02-04
IPC分类号： C12P1934
CPC分类号： C12Q1/6888 , C12Q1/6806 , C12Q1/6879 , C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , Y10T436/143333 , C12Q2527/125 , C12Q2525/125
摘要： Described are non-invasive methods of detecting the presence of specific nucleic acid sequences by analyzing urine samples for the presence of nucleic acids that have crossed the kidney barrier. More specifically, the present invention encompasses methods of detecting specific fetal nucleic acid sequences by analyzing maternal urine for the presence of fetal nucleic acids. The invention further encompasses methods of detecting specific nucleic acid alterations for the diagnosis of disease.
摘要翻译： 描述了通过分析尿样本中已经越过肾屏障的核酸的存在来检测特异性核酸序列的存在的非侵入性方法。 更具体地，本发明包括通过分析胎儿核酸存在的母体尿检测特异性胎儿核酸序列的方法。 本发明还包括检测用于疾病诊断的特异性核酸改变的方法。
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公开(公告)号：US08486626B2
公开(公告)日：2013-07-16
申请号：US12229378
申请日：2008-08-22
CPC分类号： C12Q1/6883 , C12Q1/705 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： Described are non-invasive methods of detecting in vivo cell death by measuring levels of ubiquitous and tissue specific miRNA. The method can be applied for detection of pathologies caused or accompanied by cell death, as well as for diagnosis of infectious disease, cytotoxic effects induced by different chemical or physical factors, and the presence of specific fetal abnormalities.
摘要翻译： 描述了通过测量普遍存在和组织特异性miRNA的水平来检测体内细胞死亡的非侵入性方法。 该方法可用于检测引起或伴有细胞死亡的病理学，以及用于诊断感染性疾病，不同化学或物理因素诱导的细胞毒性作用，以及特定胎儿异常的存在。
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公开(公告)号：US06492144B1
公开(公告)日：2002-12-10
申请号：US09634732
申请日：2000-08-03
IPC分类号： C12P1934
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q1/6879 , C12Q2600/154 , C12Q2600/156 , Y10T436/143333 , C12Q2527/125 , C12Q2525/125
摘要： Described are non-invasive methods of detecting the presence of specific nucleic acid sequences as well as nucleic acid modifications and alterations by analyzing urine samples for the presence of transrenal nucleic acids. More specifically, the present invention encompasses methods of detecting specific fetal nucleic acid sequences and fetal sequences that contained modified nucleotides by analyzing maternal urine for the presence of fetal nucleic acids. The invention further encompasses methods of detecting specific nucleic acid modifications for the diagnosis of diseases, such as cancer and pathogen infections, and detection of genetic predisposition to various diseases. The invention specifically encompasses methods of analyzing specific nucleic acid modifications for the monitoring of cancer treatment. The invention further encompasses methods of analyzing specific nucleic acids in urine to track the success of transplanted cells, tissues and organs. The invention also encompasses methods for evaluating the effects of environmental factors and aging on the genome.
摘要翻译： 描述了通过分析尿液样品来检测特定核酸序列的存在以及核酸修饰和改变的非侵入性方法，用于存在跨肾脏核酸。 更具体地，本发明包括通过分析胎儿核酸存在的母体尿来检测含有修饰的核苷酸的特定胎儿核酸序列和胎儿序列的方法。 本发明还包括检测用于诊断疾病如癌症和病原体感染的特异性核酸修饰以及检测各种疾病的遗传易感性的方法。 本发明具体包括分析用于监测癌症治疗的特异性核酸修饰的方法。 本发明还包括分析尿中的特定核酸以追踪移植细胞，组织和器官的成功的方法。 本发明还包括评估环境因素和老化对基因组的影响的方法。
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7.发明申请公开(公告)号：US20100068711A1
公开(公告)日：2010-03-18
申请号：US12505183
申请日：2009-07-17
IPC分类号： C12Q1/68
CPC分类号： C12Q1/705 , C12Q1/6806 , C12Q1/6846 , C12Q1/6851 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2525/204 , C12Q2523/308 , C12Q2565/101 , C12Q2525/186 , C12Q2525/207 , C12Q2525/161
摘要： The present invention provides highly sensitive methods used for diagnosing and monitoring various diseases and disorders by detecting and analyzing “ultra short” (20-50 base pair) nucleic acids obtained from bodily fluids.
摘要翻译： 本发明通过检测和分析从体液获得的“超短”（20-50碱基对）核酸，提供用于诊断和监测各种疾病和病症的高度敏感的方法。
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公开(公告)号：US06287820B1
公开(公告)日：2001-09-11
申请号：US09609162
申请日：2000-07-03
IPC分类号： C12P1934
CPC分类号： C12Q1/6888 , C12Q1/6806 , C12Q1/6879 , C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , Y10T436/143333 , C12Q2527/125 , C12Q2525/125
摘要： Described are non-invasive methods of detecting and/or quantifying specific nucleic acid sequences by analyzing urine samples for nucleic acids that have crossed the kidney barrier. More specifically, the present invention encompasses methods of analyzing specific fetal nucleic acid sequences by analyzing maternal urine for the presence of fetal nucleic acids. The invention further encompasses methods of analyzing specific nucleic acid alterations for the diagnosis of disease. The invention encompasses methods of analyzing specific nucleic acid alterations for the diagnosis of cancer and the monitoring of its treatment. The invention further encompasses methods of analyzing specific nucleic acids in urine to track the success of transplanted cells, tissues and organs.
摘要翻译： 描述了通过分析已经越过肾屏障的核酸的尿样本来检测和/或定量特定核酸序列的非侵入性方法。 更具体地，本发明包括通过分析胎儿核酸存在的母体尿来分析特定胎儿核酸序列的方法。 本发明还包括分析用于疾病诊断的特异性核酸改变的方法。 本发明包括分析用于诊断癌症的特定核酸改变和其治疗监测的方法。 本发明还包括分析尿中的特定核酸以追踪移植细胞，组织和器官的成功的方法。
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公开(公告)号：US08642261B2
公开(公告)日：2014-02-04
申请号：US13126081
申请日：2009-10-26
申请人： Samuil R. Umansky , Zhenghan Xin , Natalya Ossina
IPC分类号： C12Q1/68
CPC分类号： C12Q1/708 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： The invention provides compositions and methods for the differential detection of high risk forms of HPV from a urine sample provided by a patient. Specifically, the invention provides primers and probes that specifically recognize and bind sequences within the E1 gene of HPV. Detection of high risk forms of HPV identify individuals at risk of developing or in the early stages of cervical carcinoma.
摘要翻译： 本发明提供了用于从患者提供的尿样中差异检测HPV的高风险形式的组合物和方法。 具体地说，本发明提供了特异性识别和结合HPV基因E1基因序列的引物和探针。 检测HPV的高风险形式识别患有发展或宫颈癌早期发生危险的个体。
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