公开(公告)号：US5611344A

公开(公告)日：1997-03-18

申请号：US611248

申请日：1996-03-05

申请人： Howard Bernstein ,  Julie A. Straub ,  Henry T. Brush ,  Richard E. Wing

发明人： Howard Bernstein ,  Julie A. Straub ,  Henry T. Brush ,  Richard E. Wing

IPC分类号： A61B8/00 ,  A61K49/22

CPC分类号： A61B8/481 ,  A61K49/223

摘要： It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporated therein. The microencapsulated perfluorocarbon is manufactured with a diameter suitable for the targeted tissue to be imaged, for example, for intravenous or oral administration. In one embodiment, bioadhesive microparticles are formed for enhanced imaging of mucosal surfaces.

摘要翻译： 已经发现，与合并有空气的微粒相比，将氟化气体，特别是全氟化碳如八氟丙烷掺入到合成的聚合物微粒中显着增强回波反应性。 制造微胶囊化全氟化碳，其直径适用于待成像的目标组织，例如用于静脉内或口服给药。 在一个实施方案中，形成生物粘附微粒用于增强粘膜表面的成像。

公开(公告)号：US6132699A

公开(公告)日：2000-10-17

申请号：US158295

申请日：1998-09-22

申请人： Howard Bernstein ,  Julie Ann Straub ,  Henry T. Brush ,  Richard E. Wing

发明人： Howard Bernstein ,  Julie Ann Straub ,  Henry T. Brush ,  Richard E. Wing

IPC分类号： A61K47/06 ,  A61B8/00 ,  A61K49/00 ,  A61K49/22 ,  A61B8/13

CPC分类号： A61B8/481 ,  A61K49/223

摘要： It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporated therein. The microencapsulated perfluorocarbon is manufactured with a diameter suitable for the targeted tissue to be imaged, for example, for intravenous or oral administration. In one embodiment, bioadhesive microparticles are formed for enhanced imaging of mucosal surfaces.

摘要翻译： 已经发现，与合并有空气的微粒相比，将氟化气体，特别是全氟化碳如八氟丙烷掺入到合成的聚合物微粒中显着增强回波反应性。 制造微胶囊化全氟化碳，其直径适用于待成像的目标组织，例如用于静脉内或口服给药。 在一个实施方案中，形成生物粘附微粒用于增强粘膜表面的成像。

公开(公告)号：US5853698A

公开(公告)日：1998-12-29

申请号：US745676

申请日：1996-11-08

申请人： Julie Ann Straub ,  Edith Mathiowitz ,  Howard Bernstein ,  Henry T. Brush ,  Richard E. Wing

发明人： Julie Ann Straub ,  Edith Mathiowitz ,  Howard Bernstein ,  Henry T. Brush ,  Richard E. Wing

IPC分类号： A61B8/00 ,  A61K49/22 ,  A61B8/13

CPC分类号： A61B8/481 ,  A61K49/223

摘要： It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporated therein. The microencapsulated perfluorocarbon is manufactured with a diameter suitable for the targeted tissue to be imaged, for example, for intravenous or oral administration. In one embodiment, bioadhesive microparticles are formed for enhanced imaging of mucosal surfaces.

摘要翻译： 已经发现，与合并有空气的微粒相比，将氟化气体，特别是全氟化碳如八氟丙烷掺入到合成的聚合物微粒中显着增强回波反应性。 制造微胶囊化全氟化碳，其直径适用于待成像的目标组织，例如用于静脉内或口服给药。 在一个实施方案中，形成生物粘附微粒用于增强粘膜表面的成像。

公开(公告)号：US4365627A

公开(公告)日：1982-12-28

申请号：US189446

申请日：1980-09-22

申请人： Richard E. Wing

发明人： Richard E. Wing

IPC分类号： A62B18/08 ,  A62B7/00

CPC分类号： A62B18/088 ,  Y10S116/25 ,  Y10S55/33 ,  Y10S55/34 ,  Y10S55/35

摘要： An improved canister for a filter-type respirator having an end-of-service life warning device which is located in a position such that all air flowing through the canister flows through the warning device after the air has flowed through at least about 50 volume percent of the filtering material contained in the respirator.

摘要翻译： 一种用于过滤式呼吸器的改进的罐，其具有使用寿命终止警告装置，其位于使空气流过至少约50体积％之后流过所述罐的所有空气流过所述警告装置的位置 的过滤材料包含在呼吸器中。