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1.发明申请Neuronally expressed stem cell factor modulates angiogenesis and neural stem cell migration to areas of brain injury 审中-公开神经元表达干细胞因子调节血管生成和神经干细胞迁移到脑损伤区域公开(公告)号：US20060286117A1
公开(公告)日：2006-12-21
申请号：US11440173
申请日：2006-05-24
申请人： Howard Fine , Lixin Sun
发明人： Howard Fine , Lixin Sun
摘要： The present invention relates to methods of promoting or inhibiting angiogenesis in humans comprising administering to a human in need thereof an effective amount of Stem Cell Factor or a modulator of Stem Cell Factor or an agonist or antagonist of c-Kit and methods of inducing migration of a neural stem or progenitor cell to a site of neurological injury in the central nervous system of a subject.
摘要翻译： 本发明涉及促进或抑制人类血管发生的方法，其包括向有需要的人施用有效量的干细胞因子或干细胞因子的调节剂或c-Kit的激动剂或拮抗剂以及诱导迁移的方法 神经干细胞或祖细胞到受试者的中枢神经系统的神经损伤部位。
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2.发明授权
公开(公告)号：US4454110A
公开(公告)日：1984-06-12
申请号：US518951
申请日：1983-08-01
申请人： Vera B. Caslavsky , Poul Gron , Howard Fine
发明人： Vera B. Caslavsky , Poul Gron , Howard Fine
CPC分类号： A61K8/042 , A61K8/21 , A61K8/4926 , A61K8/585 , A61Q11/00 , Y10S514/944
摘要： A self-gelling composition for topical application, particularly in the oral cavity, which composition comprises: an aqueous solution of ethyl orthosilicate monomer or prepolymer; an active ingredient, such as a fluoride, or an antibiotic for sustained release in the area of topical application; and a gelation agent, to provide, on mixing of the composition, the in situ gelling of the composition within a predetermined time period after topical application, to provide the penetration properties of a low-viscosity solution with the sustained release of the active ingredient from the gel.
摘要翻译： 用于局部施用的自凝胶组合物，特别是在口腔中，该组合物包含：原硅酸乙酯单体或预聚物的水溶液; 活性成分，如氟化物，或在局部应用领域持续释放的抗生素; 和凝胶剂，以在组合物混合后，在局部施用之后的预定时间段内提供组合物的原位胶凝，以提供低粘度溶液的渗透性能，从而将活性成分从 凝胶。
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3.发明申请公开(公告)号：US20100331858A1
公开(公告)日：2010-12-30
申请号：US12811506
申请日：2009-01-30
申请人： Nabil Simaan , Howard Fine , Wei Wei , Stanley Chang
发明人： Nabil Simaan , Howard Fine , Wei Wei , Stanley Chang
CPC分类号： A61F2/82 , A61B34/30 , A61B34/37 , A61B34/71 , A61B34/77 , A61B2017/00331 , A61B2017/00345 , A61B2017/00991 , A61B2034/304 , A61B2090/064 , A61F2/966 , A61F9/007
摘要： Systems, devices, and methods for robot-assisted microsurgical stenting are described herein. In some embodiments a tele-robotic microsurgical system for eye surgery include: a tele-robotic master and a slave hybrid-robot; wherein the tele-robotic master has at least one master slave interface controlled by a medical professional; wherein the slave hybrid-robot has at least one robotic arm attached to a frame releasably attached to a patient's head; wherein the at least one robotic arm has a parallel robot and a serial robot; and wherein the serial robot includes a stenting unit which includes a support tube, a pre-bent tube mounted within the support tube and a guide wire extending from the support tube for carrying a stent and for piercing a blood vessel.
摘要翻译： 本文描述了用于机器人辅助显微外科支架置入术的系统，装置和方法。 在一些实施例中，用于眼科手术的远程机器人显微手术系统包括远程机器人主机和从属混合机器人; 其中远程机器人主机具有由医疗专业人员控制的至少一个主从接口; 其中所述从动混合机器人具有附接到可释放地附接到患者头部的框架的至少一个机器人手臂; 其中所述至少一个机器臂具有并联机器人和串行机器人; 并且其中所述串联机器人包括支架单元，所述支架单元包括支撑管，安装在所述支撑管内的预弯曲管和从所述支撑管延伸以用于承载支架和用于刺穿血管的导丝。
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4.发明申请SYSTEMS, DEVICES, AND METHODS FOR SURGERY ON A HOLLOW ANATOMICALLY SUSPENDED ORGAN 审中-公开系统，设备和方法，用于在中空解锁机构上进行手术公开(公告)号：US20100010504A1
公开(公告)日：2010-01-14
申请号：US12441566
申请日：2007-09-19
申请人： Nabil Simaan , Wei Wei , Roger Goldman , Howard Fine , Stanley Chang
发明人： Nabil Simaan , Wei Wei , Roger Goldman , Howard Fine , Stanley Chang
IPC分类号： A61B19/00
CPC分类号： A61B90/16 , A61B34/30 , A61B34/35 , A61B34/37 , A61B34/70 , A61B34/71 , A61B34/75 , A61B34/76 , A61B90/20 , A61B2017/00867 , A61B2017/3407 , A61B2034/304 , A61B2090/064 , A61B2090/306 , A61F9/007
摘要： Systems, devices, and methods for surgery on a hollow anatomically suspended organ are described herein. In some embodiments a tele-robotic microsurgical system for eye surgery include: a tele-robotic master and a slave hybrid-robot; wherein the tele-robotic master has at least two master slave interfaces controlled by a medical professional; wherein the slave hybrid-robot has at least two robotic arms attached to a frame releasably attached to a patient's head; wherein the at least two robotic arms each have a parallel robot and a serial robot; and wherein the serial robot includes a tube housing a cannula.
摘要翻译： 本文描述了在中空解剖悬挂的器官上进行手术的系统，装置和方法。 在一些实施例中，用于眼科手术的远程机器人显微手术系统包括远程机器人主机和从属混合机器人; 其中远程机器人主机具有由医疗专业人员控制的至少两个主从接口; 其中所述从动混合机器人具有附接到可释放地附接到患者头部的框架的至少两个机器人手臂; 其中所述至少两个机器人臂各具有并联机器人和串行机器人; 并且其中所述串联机器人包括容纳插管的管。
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5.发明授权
公开(公告)号：US4411889A
公开(公告)日：1983-10-25
申请号：US381530
申请日：1982-05-24
申请人： Vera B. Caslavsky , Poul Gron , Howard Fine
发明人： Vera B. Caslavsky , Poul Gron , Howard Fine
CPC分类号： A61K8/042 , A61K8/21 , A61K8/4926 , A61K8/585 , A61Q11/00
摘要： A self-gelling composition for topical application, particularly in the oral cavity, which composition comprises: an aqueous solution of ethyl orthosilicate monomer or prepolymer; an active ingredient, such as a fluoride, or an antibiotic for sustained release in the area of topical application; and a gelation agent, to provide, on mixing of the composition, the in situ gelling of the composition within a predetermined time period after topical application, to provide the penetration properties of a low-viscosity solution with the sustained release of the active ingredient from the gel.
摘要翻译： 用于局部施用的自凝胶组合物，特别是在口腔中，该组合物包含：原硅酸乙酯单体或预聚物的水溶液; 活性成分，如氟化物，或在局部应用领域持续释放的抗生素; 和凝胶剂，以在组合物混合后，在局部施用之后的预定时间段内提供组合物的原位胶凝，以提供低粘度溶液的渗透性能，从而将活性成分从 凝胶。
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