公开(公告)号：US20020101785A1

公开(公告)日：2002-08-01

申请号：US09771317

申请日：2001-01-26

申请人： Howmedica Osteonics Corp.

发明人： Brian Edwards ,  Paul Higham ,  Joseph Zitelli

IPC分类号： B01F005/06 ,  B01F005/12 ,  A61M037/00

CPC分类号： B01F11/0082 ,  A61B17/8825 ,  A61C5/62 ,  A61C5/68 ,  A61J1/2055 ,  A61J1/2096 ,  A61M5/31596 ,  B01F5/0685 ,  B01F5/0688 ,  B01F13/002 ,  B01F15/0225 ,  B01F2215/0029

摘要： An apparatus and method for mixing a liquid component and a powdered component to form a bone filler has first and second syringes each having a barrel, a plunger and an exit port. The plunger is moveable with the barrel of each syringe along a longitudinal axis of the barrel. An end portion of each plunger extends beyond the end of each barrel when the plunger tip is spaced from the exit port and can be activated to move the plunger tip toward the exit port. A mechanism for mixing the liquid and powdered components is operatively connected to each of the barrels and plunger of the first and second syringes so that the relative sliding movement of first and second parts of the mechanism simultaneously moves the plungers and barrels of the first and second syringes relative to one another to move the combined liquid and powdered components back and forth between the first and second syringe.

摘要翻译： 用于混合液体组分和粉末组分以形成骨填料的装置和方法具有每个具有筒，柱塞和出口的第一和第二注射器。 柱塞可以沿着每个注射器的枪管沿着镜筒的纵向轴线移动。 当柱塞尖端与出口间隔开时，每个柱塞的端部延伸超过每个筒的端部，并且可以被启动以使柱塞尖端朝向出口移动。 用于混合液体和粉末组分的机构可操作地连接到第一和第二注射器的每个桶和柱塞，使得机构的第一和第二部分的相对滑动运动同时移动第一和第二注射器的柱塞和桶 注射器相对于彼此在第一和第二注射器之间来回移动组合的液体和粉末组分。

公开(公告)号：US20040141903A1

公开(公告)日：2004-07-22

申请号：US10346873

申请日：2003-01-17

申请人： Howmedica Osteonics Corp.

发明人： Joseph Zitelli ,  Peter Maher ,  Ger Insley

IPC分类号： C01B025/26

CPC分类号： A61K6/033 ,  A61K6/0008 ,  A61K6/024 ,  A61K6/0643 ,  A61L24/0063 ,  A61L24/02 ,  C04B12/02 ,  C04B28/344 ,  C04B40/0028 ,  C04B2111/00836 ,  C04B22/064 ,  C04B40/0608 ,  C04B22/16 ,  C04B28/34 ,  C04B12/025

摘要： A mixture of two or more calcium phosphate compositions are combined with an aqueous solution and are useful as bone fillers on bone cements such as orthopedic and dental cements and remineralizers. The mixtures self-harden to substantially form hydroxyapatite, the mineral phase of bone and tooth enamel. The at least one or more of precursors is prepared in a manner resulting in its having an extremely low moisture level. The use of low moisture components results in an improved shelf life to the mixture.

摘要翻译： 将两种或更多种磷酸钙组合物的混合物与水溶液组合，并且可用作骨水泥上的骨填料，例如矫形和牙科粘固剂和再矿化剂。 混合物自硬化以基本形成羟基磷灰石，骨和牙釉质的矿物相。 所述至少一种或多种前体以导致其具有非常低的水分含量的方式制备。 使用低水分组分可以改善混合物的保质期。

公开(公告)号：US20040001911A1

公开(公告)日：2004-01-01

申请号：US10610730

申请日：2003-07-01

申请人： Howmedica Osteonics Corp.

发明人： Christopher Scott ,  Joseph Zitelli ,  Paul Higham

IPC分类号： A61L002/00

CPC分类号： A61L27/54 ,  A61L27/32 ,  A61L2300/406 ,  A61L2300/606

摘要： A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.

公开(公告)号：US20040131754A1

公开(公告)日：2004-07-08

申请号：US10611147

申请日：2003-07-01

申请人： Howmedica Osteonics Corp.

发明人： Joseph Zitelli ,  Paul Higham ,  Paresh Dalal ,  Monica Hawkins ,  Renwen Zhang

IPC分类号： A61L002/00

CPC分类号： A61L27/54 ,  A61L27/32 ,  A61L2300/252 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/606

摘要： A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein such as OP-1 protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.

摘要翻译： 将具有治疗剂如抗生素或骨形态发生蛋白如OP-1蛋白的涂层施用于植入物的方法使用磷酸钙涂覆的金属植入物的高表面积作为治疗剂的储存库。 植入物涂覆有一层或多层磷酸钙矿物质，如羟基磷灰石。 在通常在水溶液中进行结晶层之后，将植入物干燥并包装。 在植入之前，立即从包装中取出植入物，并用含有治疗剂的水溶液润湿磷酸钙的结晶层。

公开(公告)号：US20030019396A1

公开(公告)日：2003-01-30

申请号：US10237499

申请日：2002-09-09

申请人： Howmedica Osteonics Corp.

发明人： Brian Edwards ,  Paul Higham ,  Joseph Zitelli

IPC分类号： A61F002/28

CPC分类号： A61L24/02 ,  A61L2430/02 ,  C04B28/344 ,  C04B38/02 ,  C04B2111/00836 ,  C04B22/10 ,  C04B24/04 ,  C04B24/06 ,  C04B22/165

摘要： A kit and a method for making a porous cement which self sets to hydroxyapatite and has an interconnected porosity is produced by mixing a calcium source and a phosphate source with a carbonate source and mixing this powdered component with a liquid component having an acid component. The liquid component comprises water or an aqueous solution containing an acid. The acid and the carbonate react to form carbon dioxide thereby producing an interconnected porosity in the normally solid self-hardening bone cement. The method requires only a relatively low weight percent of the acid and base to be mixed with the liquid and powder cement components.

摘要翻译： 通过将钙源和磷酸盐源与碳酸盐源混合并将该粉末状组分与具有酸组分的液体组分混合来制备用于制备自羟基磷灰石并具有相互连通孔的多孔水泥的试剂盒和方法。 液体组分包含水或含有酸的水溶液。 酸和碳酸盐反应形成二氧化碳，从而在通常固体自硬骨水泥中产生相互连通的孔隙。 该方法仅需要相对较低重量的酸和碱与液体和粉末水泥组分混合。

公开(公告)号：US20020101784A1

公开(公告)日：2002-08-01

申请号：US09770982

申请日：2001-01-26

申请人： Howmedica Osteonics Corp.

发明人： Brian Edwards ,  Paul Higham ,  Joseph Zitelli

IPC分类号： B01F011/00

CPC分类号： B01F11/0014 ,  A61B2017/8838 ,  A61C5/68 ,  B01F3/12 ,  B01F11/0008 ,  B01F2215/0029

摘要： An apparatus for mixing dry and liquid components is used to form a setting paste. A holder is mounted on the apparatus for reciprocating movement with respect to a base of the apparatus. The movement has an amplitude with components in first and second perpendicular directions. A drive system is operatively connected to the holder for imparting said reciprocating movement to said holder at a predetermined number of cycles per minute. A container having a mass of said dry and liquid components therein is mounted in the holder. The mass, amplitude and cycles per minute of reciprocation being chosen to produce an energy input of at least about 3null10null3 Joules per second per 3 cc of mixture.