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公开(公告)号：US20020101785A1
公开(公告)日：2002-08-01
申请号：US09771317
申请日：2001-01-26
发明人： Brian Edwards , Paul Higham , Joseph Zitelli
IPC分类号： B01F005/06 , B01F005/12 , A61M037/00
CPC分类号： B01F11/0082 , A61B17/8825 , A61C5/62 , A61C5/68 , A61J1/2055 , A61J1/2096 , A61M5/31596 , B01F5/0685 , B01F5/0688 , B01F13/002 , B01F15/0225 , B01F2215/0029
摘要： An apparatus and method for mixing a liquid component and a powdered component to form a bone filler has first and second syringes each having a barrel, a plunger and an exit port. The plunger is moveable with the barrel of each syringe along a longitudinal axis of the barrel. An end portion of each plunger extends beyond the end of each barrel when the plunger tip is spaced from the exit port and can be activated to move the plunger tip toward the exit port. A mechanism for mixing the liquid and powdered components is operatively connected to each of the barrels and plunger of the first and second syringes so that the relative sliding movement of first and second parts of the mechanism simultaneously moves the plungers and barrels of the first and second syringes relative to one another to move the combined liquid and powdered components back and forth between the first and second syringe.
摘要翻译： 用于混合液体组分和粉末组分以形成骨填料的装置和方法具有每个具有筒，柱塞和出口的第一和第二注射器。 柱塞可以沿着每个注射器的枪管沿着镜筒的纵向轴线移动。 当柱塞尖端与出口间隔开时，每个柱塞的端部延伸超过每个筒的端部，并且可以被启动以使柱塞尖端朝向出口移动。 用于混合液体和粉末组分的机构可操作地连接到第一和第二注射器的每个桶和柱塞，使得机构的第一和第二部分的相对滑动运动同时移动第一和第二注射器的柱塞和桶 注射器相对于彼此在第一和第二注射器之间来回移动组合的液体和粉末组分。
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公开(公告)号：US20040001911A1
公开(公告)日：2004-01-01
申请号：US10610730
申请日：2003-07-01
发明人： Christopher Scott , Joseph Zitelli , Paul Higham
IPC分类号： A61L002/00
CPC分类号： A61L27/54 , A61L27/32 , A61L2300/406 , A61L2300/606
摘要： A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.
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公开(公告)号：US20020127280A1
公开(公告)日：2002-09-12
申请号：US09754882
申请日：2001-01-05
发明人： Paul Higham
IPC分类号： A61K031/715 , A61K033/42
CPC分类号： A61L27/12 , A61F2/28 , A61F2002/4631 , A61F2310/00293 , Y10S514/951 , Y10S514/952
摘要： A method for controlling the formation of a hydroxyapatite bone filler from dry calcium phosphate precursors in an aqueous solution uses coated sodium phosphate powder. The sodium phosphate powder is coated with a water soluble cellulose. Until the calcium dissolves in the aqueous solution setting of the cellulose phosphate cements proceeds slowly but when the exposed sodium phosphate particles start to solubilize in the aqueous solution the setting rate increases.
摘要翻译： 用于控制水溶液中干磷酸钙前体形成羟基磷灰石骨填料的方法使用涂覆的磷酸钠粉末。 磷酸钠粉末涂有水溶性纤维素。 直到钙溶解在纤维素磷酸盐水泥的水溶液中才缓慢进行，但是当暴露的磷酸钠颗粒开始溶解在水溶液中时，凝固速率增加。
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公开(公告)号：US20040212130A1
公开(公告)日：2004-10-28
申请号：US10847077
申请日：2004-05-17
发明人： Paul Higham , Philip F. Williams , John Lapszynski , Chau Ngo
IPC分类号： B29C045/00 , B29C071/00 , B29C071/04
CPC分类号： A61F2/442 , A61F2002/444 , A61L27/52 , B29C45/00 , Y10S524/916
摘要： A high strength hydrogel having a constant swelling pressure upon implantation and thereafter is formed by preparing a hydrogel solution and then injecting the solution into a mold and cause to gel. The molded gel is then washed in a saline solution from about one day to twelve weeks, after which the gel is irradiated for sterilization purposes, dehydrated and packaged. The pre-treatment with the use of a physiologic solution results in an implant which exhibits a constant swelling pressure profile after implantation.
摘要翻译： 通过制备水凝胶溶液然后将溶液注入模具并使其凝胶化而形成植入后具有恒定溶胀压力的高强度水凝胶。 然后将模制的凝胶在盐水溶液中洗涤约1天至12周，此后将凝胶照射灭菌，脱水并包装。 使用生理溶液的预处理导致植入物在植入后呈现恒定的溶胀压力分布。
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公开(公告)号：US20040131754A1
公开(公告)日：2004-07-08
申请号：US10611147
申请日：2003-07-01
发明人： Joseph Zitelli , Paul Higham , Paresh Dalal , Monica Hawkins , Renwen Zhang
IPC分类号： A61L002/00
CPC分类号： A61L27/54 , A61L27/32 , A61L2300/252 , A61L2300/406 , A61L2300/414 , A61L2300/606
摘要： A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein such as OP-1 protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.
摘要翻译： 将具有治疗剂如抗生素或骨形态发生蛋白如OP-1蛋白的涂层施用于植入物的方法使用磷酸钙涂覆的金属植入物的高表面积作为治疗剂的储存库。 植入物涂覆有一层或多层磷酸钙矿物质，如羟基磷灰石。 在通常在水溶液中进行结晶层之后，将植入物干燥并包装。 在植入之前，立即从包装中取出植入物，并用含有治疗剂的水溶液润湿磷酸钙的结晶层。
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公开(公告)号：US20030019396A1
公开(公告)日：2003-01-30
申请号：US10237499
申请日：2002-09-09
发明人： Brian Edwards , Paul Higham , Joseph Zitelli
IPC分类号： A61F002/28
CPC分类号： A61L24/02 , A61L2430/02 , C04B28/344 , C04B38/02 , C04B2111/00836 , C04B22/10 , C04B24/04 , C04B24/06 , C04B22/165
摘要： A kit and a method for making a porous cement which self sets to hydroxyapatite and has an interconnected porosity is produced by mixing a calcium source and a phosphate source with a carbonate source and mixing this powdered component with a liquid component having an acid component. The liquid component comprises water or an aqueous solution containing an acid. The acid and the carbonate react to form carbon dioxide thereby producing an interconnected porosity in the normally solid self-hardening bone cement. The method requires only a relatively low weight percent of the acid and base to be mixed with the liquid and powder cement components.
摘要翻译： 通过将钙源和磷酸盐源与碳酸盐源混合并将该粉末状组分与具有酸组分的液体组分混合来制备用于制备自羟基磷灰石并具有相互连通孔的多孔水泥的试剂盒和方法。 液体组分包含水或含有酸的水溶液。 酸和碳酸盐反应形成二氧化碳，从而在通常固体自硬骨水泥中产生相互连通的孔隙。 该方法仅需要相对较低重量的酸和碱与液体和粉末水泥组分混合。
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公开(公告)号：US20040054413A1
公开(公告)日：2004-03-18
申请号：US10244306
申请日：2002-09-16
IPC分类号： A61F002/44
CPC分类号： A61L27/52 , A61F2/30965 , A61F2/441 , A61F2/442 , A61F2002/3008 , A61F2002/30616 , A61F2002/30971 , A61F2002/444 , A61F2250/0064 , A61F2250/0098 , A61F2310/00023 , A61F2310/00131 , A61F2310/00137 , A61F2310/00149 , A61F2310/00155 , A61L27/50 , A61L2430/38
摘要： A spinal implant for replacing the natural nucleus of the disc made from a polymer such as hydrogel having a radiopaque material located within the polymer. The material may be in the form of a powder disbursed throughout the polymer or may be in he form of a powder disbursed in layers or in other specific locations within the polymer. The radiopaque material is metal such as gold, tungsten, titanium, tantalum or platinum. The metal may also be in the form of a foil or wire located within the hydrogel such as polyurethane, thereby making the implant visible on x-rays. Other polymers besides hydrogel may be used with the radiopaque material being disbursed therein.
摘要翻译： 用于替换由诸如水凝胶的聚合物制成的盘的天然核的脊椎植入物，其具有位于聚合物内的不透射线材料。 该材料可以是分散在整个聚合物中的粉末的形式，或者可以是分层形式或分散在聚合物内的其它特定位置的形式。 不透射线的材料是诸如金，钨，钛，钽或铂的金属。 金属也可以是位于水凝胶内的箔或线的形式，例如聚氨酯，从而使植入物在x射线上可见。 可以使用除水凝胶之外的其它聚合物，其中不透射材料被分配。
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公开(公告)号：US20030104069A1
公开(公告)日：2003-06-05
申请号：US10340442
申请日：2003-01-10
发明人： Paul Higham
IPC分类号： A61K033/42 , A61K009/16 , A61K009/50
CPC分类号： A61L27/12 , A61F2/28 , A61F2002/4631 , A61F2310/00293 , Y10S514/951 , Y10S514/952
摘要： A method for controlling the formation of a hydroxyapatite bone filler from dry calcium phosphate precursors in an aqueous solution uses coated sodium phosphate powder. The sodium phosphate powder is coated with a water soluble cellulose. Until the cellulose dissolves in the aqueous solution setting of the calcium phosphate cements proceeds slowly but when the exposed sodium phosphate particles start to solubilize in the aqueous solution the setting rate increases.
摘要翻译： 用于控制水溶液中干磷酸钙前体形成羟基磷灰石骨填料的方法使用涂覆的磷酸钠粉末。 磷酸钠粉末涂有水溶性纤维素。 直到纤维素溶解在磷酸钙水泥的水溶液中才缓慢进行，但是当暴露的磷酸钠颗粒开始溶解在水溶液中时，凝固速率增加。
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公开(公告)号：US20020101784A1
公开(公告)日：2002-08-01
申请号：US09770982
申请日：2001-01-26
发明人： Brian Edwards , Paul Higham , Joseph Zitelli
IPC分类号： B01F011/00
CPC分类号： B01F11/0014 , A61B2017/8838 , A61C5/68 , B01F3/12 , B01F11/0008 , B01F2215/0029
摘要： An apparatus for mixing dry and liquid components is used to form a setting paste. A holder is mounted on the apparatus for reciprocating movement with respect to a base of the apparatus. The movement has an amplitude with components in first and second perpendicular directions. A drive system is operatively connected to the holder for imparting said reciprocating movement to said holder at a predetermined number of cycles per minute. A container having a mass of said dry and liquid components therein is mounted in the holder. The mass, amplitude and cycles per minute of reciprocation being chosen to produce an energy input of at least about 3null10null3 Joules per second per 3 cc of mixture.
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