公开(公告)号：US5008295A

公开(公告)日：1991-04-16

申请号：US225020

申请日：1988-07-28

申请人： Hoyoku Nishino ,  Ryozo Iwasaki ,  Akio Okabe ,  Yuki Yogo

发明人： Hoyoku Nishino ,  Ryozo Iwasaki ,  Akio Okabe ,  Yuki Yogo

IPC分类号： A61K31/015

CPC分类号： A61K31/015

摘要： A method of inhibiting the growth of cancers susceptible to treatment with .alpha.-carotene, which comprises: administering an effective cancer cell growth inhibiting amount of .alpha.-carotene to a manmal having said cancer cells.

公开(公告)号：US06312697B1

公开(公告)日：2001-11-06

申请号：US09256206

申请日：1999-02-24

申请人： Govind J. Kapadia ,  Harukuni Tokuda ,  Takao Konoshima ,  Midori Takasaki ,  Hoyoku Nishino

发明人： Govind J. Kapadia ,  Harukuni Tokuda ,  Takao Konoshima ,  Midori Takasaki ,  Hoyoku Nishino

IPC分类号： A61K3578

CPC分类号： G01N33/5017

摘要： A method of reducing the percentage of Epstein-Barr virus genome-carrying cells which exhibit Epstein-Barr virus early antigen induction, where the Epstein-Barr virus genone-carrying cells have been cultivated in the presence of at least one tumor-promoting chemical. The method is carried out by cultivating Epstein-Barr virus genome-carrying cells in the presence of a tumor-promoting chemical; and treating the Epstein-Barr virus genome-carrying cells with betanins. The betanins are effectively reduce the incidence of Epstein-Barr virus early antigen induction in the cultivated Epstein-Barr virus genome-carrying cells.

摘要翻译： 一种降低表现出爱泼斯坦 - 巴尔病毒早期抗原诱导的爱泼斯坦 - 巴尔病毒基因组携带细胞的百分比的方法，其中在至少一种促肿瘤化学物质存在下培养含有爱泼斯坦 - 巴尔病毒基因的细胞。 该方法通过在促进肿瘤的化学物质的存在下培养含有Epstein-Barr病毒基因组的细胞进行; 并用β-甜菜碱治疗带有EB病毒基因组的细胞。 甜菜碱有效地降低了Epstein-Barr病毒基因组载体细胞中Epstein-Barr病毒早期抗原诱导的发生率。

公开(公告)号：US06277378B1

公开(公告)日：2001-08-21

申请号：US09256200

申请日：1999-02-24

申请人： Govind J. Kapadia ,  Harukuni Tokuda ,  Takao Konoshima ,  Midori Takasaki ,  Hoyoku Nishino

发明人： Govind J. Kapadia ,  Harukuni Tokuda ,  Takao Konoshima ,  Midori Takasaki ,  Hoyoku Nishino

IPC分类号： A61K3578

CPC分类号： G01N33/5017

摘要： A method of preventing inflammation of epidermal tissue resulting from exposure to a chemical by topically applying an acetone solution containing a natural colorant to the exposed tissue. The natural colorant is preferably a paprika extract containing a mixture of capsanthin, capsorubin, and their acyl esters, or an annatto seed extract containing a mixture of cis-bixin, trans-bixin, and cis-norbixin.

摘要翻译： 一种通过将暴露的组织局部施用含有天然着色剂的丙酮溶液来预防由暴露于化学物质而引起的表皮组织的炎症的方法。 天然着色剂优选是含有辣椒红，capsorubin及其酰基酯的混合物的辣椒粉提取物，或含有顺式 - 双辛辛，顺式 - 降冰片辛的混合物的ann to籽提取物。

公开(公告)号：US5804567A

公开(公告)日：1998-09-08

申请号：US919716

申请日：1997-08-27

申请人： Shu Jun Cheng ,  De Chang Wang ,  Yong Su Zhen ,  Hoyoku Nishino ,  Yukihiko Hara

发明人： Shu Jun Cheng ,  De Chang Wang ,  Yong Su Zhen ,  Hoyoku Nishino ,  Yukihiko Hara

IPC分类号： A61K45/06 ,  A01N43/04 ,  A01N43/16 ,  A61K31/715 ,  A61K31/35

CPC分类号： A61K45/06

摘要： A method for treating cancer in a patient by administering to a patient an nti-cancer effective amount of an anti-metabolite selected from the group consisting of 1-.beta.-arabinofuranosylcytosine and 4-amino-4-deoxy-10-methylfolic acid and an anti-oxidant effective amount of a tea polyphenol compound selected from the group consisting of a tea catechin, a theaflavin and a combination of a tea catechin and a theaflavin.

摘要翻译： 一种通过向患者施用抗癌有效量的抗代谢物，其用于治疗患者的癌症的方法，所述抗代谢物选自1-硫脲呋喃糖基胞嘧啶和4-氨基-4-脱氧-10-甲基己酸，和 抗氧化剂有效量的茶多酚化合物，其选自茶儿茶素，茶黄素以及茶儿茶素和茶黄素的组合。

公开(公告)号：US06291215B1

公开(公告)日：2001-09-18

申请号：US09256205

申请日：1999-02-24

申请人： Govind J. Kapadia ,  Harukuni Tokuda ,  Takao Konoshima ,  Midori Takasaki ,  Hoyoku Nishino

发明人： Govind J. Kapadia ,  Harukuni Tokuda ,  Takao Konoshima ,  Midori Takasaki ,  Hoyoku Nishino

IPC分类号： A61K3135

CPC分类号： G01N33/5017

摘要： A method of reducing the percentage of Epstein-Barr virus genome-carrying cells which exhibit Epstein-Barr virus early antigen induction, where the Epstein-Barr virus genome-carrying cells have been cultivated in the presence of at least one tumor-promoting or tumor-inducing chemical. The method is carried out by cultivating Epstein-Barr virus genome-carrying cells in the presence of a tumor-promoting or tumor-inducing chemical; and treating the Epstein-Barr virus genome-carrying cells with a synthetic fluorescein dye. The dyes effectively reduce the incidence of Epstein-Barr virus early antigen induction in the cultivated Epstein-Barr virus genome-carrying cells.

摘要翻译： 一种降低Epstein-Barr病毒基因组携带细胞百分比的方法，其表现出Epstein-Barr病毒早期抗原诱导，其中已经在至少一种肿瘤促进或肿瘤存在下培养了Epstein-Barr病毒基因组携带细胞 诱导化学品。 该方法通过在肿瘤促进或肿瘤诱导化学品的存在下培养含有Epstein-Barr病毒基因组的细胞进行; 并用合成荧光素染料处理含有Epstein-Barr病毒基因组的细胞。 这些染料有效地降低了Epstein-Barr病毒基因组载体细胞中Epstein-Barr病毒早期抗原诱导的发生率。

公开(公告)号：US06284224B1

公开(公告)日：2001-09-04

申请号：US09256201

申请日：1999-02-24

申请人： Govind J. Kapadia ,  Harunkuni Tokoda ,  Takao Konoshima ,  Midori Takasaki ,  Hoyoku Nishino

发明人： Govind J. Kapadia ,  Harunkuni Tokoda ,  Takao Konoshima ,  Midori Takasaki ,  Hoyoku Nishino

IPC分类号： A61K3135

CPC分类号： G01N33/5017

摘要： A method of treating a group of mammals which have been topically exposed to a tumor promoter or a tumor initiator so as to reduce the percentage of mammals which exhibit formation of epidermal tumors. The topically exposed tissue is treated with an acetone solution containing a defined amount of a synthetic colorant. Preferably, the synthetic colorant is tartrazine or erythrosine B.

摘要翻译： 一种治疗已经局部暴露于肿瘤启动子或肿瘤引发剂的一组哺乳动物的方法，以减少表现出表皮肿瘤形成的哺乳动物的百分比。 用含有限定量的合成着色剂的丙酮溶液处理局部暴露的组织。 优选地，合成着色剂是酒石黄或赤藓红B.

公开(公告)号：US5935581A

公开(公告)日：1999-08-10

申请号：US845166

申请日：1997-04-21

申请人： Govind J. Kapadia ,  Harukuni Tokuda ,  Takao Konoshima ,  Midori Takasaki ,  Hoyoku Nishino

发明人： Govind J. Kapadia ,  Harukuni Tokuda ,  Takao Konoshima ,  Midori Takasaki ,  Hoyoku Nishino

IPC分类号： A61K36/81 ,  A61K41/00 ,  G01N33/50 ,  A61K35/78

CPC分类号： G01N33/5017

摘要： The invention relates to a method of determining the effect of betanins on tumor formation in epidermal tissue in mammals which have been exposed to a substance which initiates or promotes tumor formation by sequentially exposing a first group of mammals to a topically applied chemical substance selected from the group consisting of tumor promoters and tumor initiators; providing the first group of mammals with drinking water containing betanins, said betanin having been extracted from beetroot; measuring a percentage of mammals in the first group which exhibit epidermal tumors; and comparing the percentage of mammals in the first group which exhibit epidermal tumors to a percentage of mammals in a second group which exhibit epidermal tumors, said mammals in the second group having been (a) exposed to a chemical substance selected from the group consisting of tumor promoters and tumor initiators and (b) providing with drinking water containing no betanins.

摘要翻译： 本发明涉及一种确定β-葡聚糖对哺乳动物表皮组织中肿瘤形成的影响的方法，所述方法已暴露于通过将第一组哺乳动物依次暴露于选自下列物质的局部施用的化学物质中来引发或促进肿瘤形成的物质 由肿瘤启动子和肿瘤引发剂组成的组; 向第一组哺乳动物提供含有甜菜碱的饮用水，所述甜菜碱已从甜菜根中提取出来; 测量显示表皮肿瘤的第一组哺乳动物的百分比; 并且将表现出表皮肿瘤的第一组中的哺乳动物的百分比与表现为表皮肿瘤的第二组中的哺乳动物的百分比进行比较，所述第二组中的哺乳动物已经（a）暴露于选自以下的化学物质： 肿瘤启动子和肿瘤引发剂，（b）提供不含甜菜碱的饮用水。

公开(公告)号：US5093505A

公开(公告)日：1992-03-03

申请号：US528826

申请日：1990-05-25

申请人： Hoyoku Nishino ,  Yukihiro Kodera ,  Toshihiko Sumida ,  Susumu Yoshida ,  Hiromichi Matsuura ,  Yoichi Itakura

发明人： Hoyoku Nishino ,  Yukihiro Kodera ,  Toshihiko Sumida ,  Susumu Yoshida ,  Hiromichi Matsuura ,  Yoichi Itakura

IPC分类号： A61K31/35 ,  A61K31/351 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4425 ,  A61K36/896 ,  A61P35/00 ,  C07D213/69 ,  C07D213/70 ,  C07D309/34 ,  C07D309/38 ,  C07D309/40

CPC分类号： C07D213/69 ,  C07D213/70 ,  C07D309/34 ,  C07D309/40

摘要： Heterocyclic compounds of the general formula: ##STR1## wherein R.sup.11 is a hydroxyl group or a lower alkoxy group, R.sup.12 is a lower alkoxy group, R.sup.13 is a saturated or unsaturated hydrocarbon group, X is an oxygen atom or a sulfur atom, and Y is an oxygen atom or --NH-- which may have a lower alkyl substituent, or salts thereof are novel and effective in controlling carcinoma.

摘要翻译： 其中R11为羟基或低级烷氧基，R12为低级烷氧基，R13为饱和或不饱和烃基，X为氧原子或硫原子，Y为氧原子或硫原子的杂环化合物， 可以具有低级烷基取代基的氧原子或-NH-，或其盐在控制癌中是新颖有效的。