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公开(公告)号：US20060030712A1
公开(公告)日：2006-02-09
申请号：US11243277
申请日：2005-10-04
申请人： Hua Zhong , Silke Dubberke , Stefan Muller , Armin Rossler , Thomas Schultz , Daniel Korey , Thomas Otten , Donald Walker , Ahmed Abdel-Magid
发明人： Hua Zhong , Silke Dubberke , Stefan Muller , Armin Rossler , Thomas Schultz , Daniel Korey , Thomas Otten , Donald Walker , Ahmed Abdel-Magid
IPC分类号： C07D403/02
CPC分类号： C07D401/04 , C07D213/51
摘要： The present invention relates to a process for preparing tetrasubstituted imidazole derivatives of the general formula (I) wherein R1, R2, R3 and R4 are as defined in the specification below. The present invention further relates to a process for preparing the compound of formula (II) and novel crystalline structures of the compound of formula (II).
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公开(公告)号：US07132544B2
公开(公告)日：2006-11-07
申请号：US11243277
申请日：2005-10-04
申请人： Hua Zhong , Silke Dubberke , Stefan Müller , Armin Rossler , Thomas W. Schultz , Daniel J. Korey , Thomas Otten , Donald G. Walker , Ahmed Abdel-Magid
发明人： Hua Zhong , Silke Dubberke , Stefan Müller , Armin Rossler , Thomas W. Schultz , Daniel J. Korey , Thomas Otten , Donald G. Walker , Ahmed Abdel-Magid
IPC分类号： C07D401/04 , C07D233/64
CPC分类号： C07D401/04 , C07D213/51
摘要： The present invention relates to a process for preparing tetrasubstituted imidazole derivatives of the general formula (I) wherein R1, R2, R3 and R4 are as defined in the specification below. The present invention further relates to a process for preparing the compound of formula (II) and novel crystalline structures of the compound of formula (II).
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3.发明授权公开(公告)号：US07067671B2
公开(公告)日：2006-06-27
申请号：US10081553
申请日：2002-02-22
申请人： Hua Zhong , Silke Dubberke , Stefan Müller , Armin Rossler , Thomas W. Schultz , Daniel J. Korey , Thomas Otten , Donald G. Walker , Ahmed Abdel-Magid
发明人： Hua Zhong , Silke Dubberke , Stefan Müller , Armin Rossler , Thomas W. Schultz , Daniel J. Korey , Thomas Otten , Donald G. Walker , Ahmed Abdel-Magid
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D213/51
摘要： The present invention relates to a process for preparing tetrasubstituted imidazole derivatives of the general formula (I) wherein R1, R2, R3 and R4 are as defined in the specification below. The present invention further relates to a process for preparing the compound of formula (II) and novel crystalline structures of the compound of formula (II).
摘要翻译： 本发明涉及制备通式（I）的四取代咪唑衍生物的方法，其中R 1，R 2，R 3和R 3， R 4如下面的说明书中所定义。 本发明还涉及制备式（II）化合物和式（II）化合物的新结晶结构的方法。
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公开(公告)号：US20060270856A1
公开(公告)日：2006-11-30
申请号：US11406794
申请日：2006-04-19
申请人： Ahmed Abdel-Magid , Steven Mehrman
发明人： Ahmed Abdel-Magid , Steven Mehrman
IPC分类号： C07D213/57 , C07D207/30 , C07C311/50
CPC分类号： C07D333/58 , C07C303/34 , C07D207/30 , C07D209/14 , C07D211/96 , C07D213/57 , C07D307/81 , C07D409/12 , C07H1/00 , C07H7/02 , C07C307/06
摘要： The present invention is directed to novel process for the preparation of sulfonylimine and sulfamide derivatives.
摘要翻译： 本发明涉及制备磺酰亚胺和磺酰胺衍生物的新方法。
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公开(公告)号：US20060105966A1
公开(公告)日：2006-05-18
申请号：US11327984
申请日：2006-01-09
IPC分类号： A61K31/7024 , C07H15/04
CPC分类号： C07H11/00
摘要： The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the treatment of epilepsy.
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公开(公告)号：US07560459B2
公开(公告)日：2009-07-14
申请号：US11265670
申请日：2005-11-02
IPC分类号： A61K31/255 , C07C311/01
摘要： The present invention is directed to novel compounds of the formula (I) wherein X, R1, R2, R3, R4, R5 and R6 are as described in the specification, processes for the preparation of and pharmaceutical compositions comprising said derivatives. The compounds of the present invention are useful for the treatment of epilepsy.The invention is further directed to a process for the preparation of compounds of formula (XX), wherein X, R3, R4, R5 and R6 are as described in the specification.
摘要翻译： 本发明涉及式（I）的新化合物，其中X，R 1，R 2，R 3，R 4，R 5和R 6如说明书中所述，制备方法和包含所述衍生物的药物组合物。 本发明的化合物可用于治疗癫痫。 本发明还涉及制备式（XX）化合物的方法，其中X，R 3，R 4，R 5和R 6如说明书中所述。
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公开(公告)号：US07041650B2
公开(公告)日：2006-05-09
申请号：US10336435
申请日：2003-01-03
摘要： The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the treatment of epilepsy.
摘要翻译： 本发明涉及抗惊厥药衍生物的新药学上可接受的盐，制备方法和含有所述盐的药物组合物，其可用于治疗癫痫。
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公开(公告)号：US20060004208A1
公开(公告)日：2006-01-05
申请号：US11215329
申请日：2005-08-30
IPC分类号： C07D231/12
CPC分类号： C07D231/12 , C07C51/083 , C07C59/88
摘要： A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III which is reacted with a compound of formula IV to form a compound of V and reacting with an alcohol to form the corresponding ester of formula VI and reacting the ester with N-methylhydroxylamine.
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公开(公告)号：US20070149765A1
公开(公告)日：2007-06-28
申请号：US11581925
申请日：2006-10-17
申请人： Ahmed Abdel-Magid
发明人： Ahmed Abdel-Magid
IPC分类号： C07K7/08
CPC分类号： C07K5/0808 , A61K38/00 , C07K1/126 , C07K5/0815 , C07K14/785
摘要： The invention realtes to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4-Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the α-carbon.
摘要翻译： 本发明涉及用于制备肺表面活性剂KL-4的21残基蛋白组分（Lys-Leu 4 N 4）4 -Sys的改进的液相方法。 这些方法适合于大规模合成，一种方法采用皂化方法来降低α-碳的固有外消旋化。
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10.发明申请Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents 审中-公开用作抗惊厥剂的新型苯并稠合的杂芳基磺酰胺衍生物公开(公告)号：US20060276528A1
公开(公告)日：2006-12-07
申请号：US11359626
申请日：2006-02-22
IPC分类号： A61K31/404 , A61K31/381 , A61K31/4025 , A61K31/343 , C07D333/02
CPC分类号： C07D307/81 , C07D209/14 , C07D333/58 , C07D409/12
摘要： The present invention is directed to novel benzo-fused heteroaryl sulfamide derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders. The present invention is further directed to a crystalline form of N-(benzo[b]thien-3-ylmethyl)-sulfamide and a process for its preparation.
摘要翻译： 本发明涉及新颖的苯并稠合杂芳基磺酰胺衍生物，含有它们的药物组合物及其在治疗癫痫和相关疾病中的用途。 本发明还涉及N-（苯并[b]噻吩-3-基甲基） - 磺酰胺的结晶形式及其制备方法。
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