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1.发明申请公开(公告)号：US20110224144A1
公开(公告)日：2011-09-15
申请号：US12903039
申请日：2010-10-12
申请人： Huda Akil , Mary Atz , William E. Bunney, JR. , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , Richard Myers , Robert C. Thompson , Hiroaki Tomita , Marquis P. Vawter , Stanley Watson
发明人： Huda Akil , Mary Atz , William E. Bunney, JR. , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , Richard Myers , Robert C. Thompson , Hiroaki Tomita , Marquis P. Vawter , Stanley Watson
IPC分类号： A61K38/02 , G01N33/566 , A61K31/7088 , A61P25/00 , A61P25/18
CPC分类号： A61K31/519 , A61K31/7088 , G01N33/6893 , G01N2800/30 , G01N2800/302
摘要： The present invention provides methods for diagnosing mental disorders (e.g., psychotic disorders such as schizophrenia). The invention also provides methods of identifying modulators of such mental disorders as well as methods of using these modulators to treat patients suffering from such mental disorders.
摘要翻译： 本发明提供了用于诊断精神障碍（例如精神病性精神障碍如精神分裂症）的方法。 本发明还提供鉴定这种精神障碍的调节剂的方法以及使用这些调节剂来治疗患有这种精神障碍的患者的方法。
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公开(公告)号：US20090117565A1
公开(公告)日：2009-05-07
申请号：US12154419
申请日：2008-05-21
申请人： Huda Akil , William E. Bunney, JR. , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , Robert C. Thompson , Richard Myers , Hiroaki Tomita , Marquis P. Vawter , Stanley Watson
发明人： Huda Akil , William E. Bunney, JR. , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , Robert C. Thompson , Richard Myers , Hiroaki Tomita , Marquis P. Vawter , Stanley Watson
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The present invention provides methods for diagnosing mental disorders such as mood disorders, including bipolar disorder I and II and major depression; The invention also provides methods of identifying modulators of such mental disorders as well as methods of using these modulators to treat patients suffering from such mental disorders.
摘要翻译： 本发明提供诊断精神障碍如心理障碍的方法，包括双相情感障碍I和II以及重度抑郁症; 本发明还提供鉴定这种精神障碍的调节剂的方法以及使用这些调节剂来治疗患有这种精神障碍的患者的方法。
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公开(公告)号：US07410759B2
公开(公告)日：2008-08-12
申请号：US10701263
申请日：2003-11-03
申请人： Huda Akil , William E. Bunney, Jr. , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , Robert C. Thompson , Richard Myers , Hiroaki Tomita , Marquis P. Vawter , Stanley Watson
发明人： Huda Akil , William E. Bunney, Jr. , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , Robert C. Thompson , Richard Myers , Hiroaki Tomita , Marquis P. Vawter , Stanley Watson
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The present invention provides methods for diagnosing mental disorders such as mood disorders, including bipolar disorder I and II and major depression. The invention also provides methods of identifying modulators of such mental disorders as well as methods of using these modulators to treat patients suffering from such mental disorders.
摘要翻译： 本发明提供诊断精神障碍如心理障碍的方法，包括双相情感障碍I和II以及重度抑郁症。 本发明还提供鉴定这种精神障碍的调节剂的方法以及使用这些调节剂来治疗患有这种精神障碍的患者的方法。
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4.发明申请COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING NEUROPSYCHIATRIC DISORDERS 审中-公开用于诊断和治疗神经缺血性疾病的组合物和方法公开(公告)号：US20110014610A1
公开(公告)日：2011-01-20
申请号：US12701177
申请日：2010-02-05
申请人： Huda Akil , Mary Atz , William E. Bunney, JR. , William Byerley , Kathleen Casey , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , Richard M. Myers , Brandi Rollins , Robert C. Thompson , Hiroaki Tomita , Marquis P. Vawter , Stanley J. Watson
发明人： Huda Akil , Mary Atz , William E. Bunney, JR. , William Byerley , Kathleen Casey , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , Richard M. Myers , Brandi Rollins , Robert C. Thompson , Hiroaki Tomita , Marquis P. Vawter , Stanley J. Watson
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/573 , G01N33/6896 , G01N2500/00 , G01N2500/04 , G01N2800/28 , G01N2800/30 , G01N2800/302 , G01N2800/304
摘要： The present invention provides methods for diagnosing mental disorders (e.g., psychotic disorders such as schizophrenia and mood disorders such as major depression disorder and bipolar disorder). The invention also provides methods of identifying modulators of such mental disorders as well as methods of using these modulators to treat patients suffering from such mental disorders.
摘要翻译： 本发明提供了用于诊断精神障碍（例如精神病性障碍如精神分裂症和情绪障碍如重性抑郁障碍和双相情感障碍）的方法。 本发明还提供鉴定这种精神障碍的调节剂的方法以及使用这些调节剂来治疗患有这种精神障碍的患者的方法。
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公开(公告)号：US08415298B2
公开(公告)日：2013-04-09
申请号：US11158530
申请日：2005-06-21
申请人： Huda Akil , William E. Bunney, Jr. , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , David M. Lyons , Margherita Molnar , Richard M. Myers , Alan F. Schatzberg , Richard Stein , Robert C. Thompson , Hiroaki Tomita , Marquis P. Vawter , Stanley J. Watson
发明人： Huda Akil , William E. Bunney, Jr. , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , David M. Lyons , Margherita Molnar , Richard M. Myers , Alan F. Schatzberg , Richard Stein , Robert C. Thompson , Hiroaki Tomita , Marquis P. Vawter , Stanley J. Watson
IPC分类号： A61K38/18
CPC分类号： C12Q1/6883 , A61K31/713 , A61K38/1825 , C07K16/22 , C12N15/1136 , C12N2310/14 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6896 , G01N33/74 , G01N2333/726 , G01N2800/304
摘要： The present invention provides methods for diagnosing mental disorders. The invention also provides methods of identifying modulators of mental disorders as well as methods of using these modulators to treat patients suffering from mental disorders.
摘要翻译： 本发明提供了诊断精神障碍的方法。 本发明还提供识别精神障碍调节剂的方法以及使用这些调节剂治疗患有精神障碍的患者的方法。
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6.发明授权Compositions and methods for diagnosing and treating neuropsychiatric disorders 有权用于诊断和治疗神经精神障碍的组合物和方法公开(公告)号：US07687235B2
公开(公告)日：2010-03-30
申请号：US11396050
申请日：2006-03-31
申请人： Huda Akil , Mary Atz , William E. Bunney, Jr. , William Byerley , Kathleen Casey , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , Richard M. Myers , Brandi Rollins , Robert C. Thompson , Hiroaki Tomita , Marquis P. Vawter , Stanley J. Watson
发明人： Huda Akil , Mary Atz , William E. Bunney, Jr. , William Byerley , Kathleen Casey , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , Richard M. Myers , Brandi Rollins , Robert C. Thompson , Hiroaki Tomita , Marquis P. Vawter , Stanley J. Watson
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/573 , G01N33/6896 , G01N2500/00 , G01N2500/04 , G01N2800/28 , G01N2800/30 , G01N2800/302 , G01N2800/304
摘要： The present invention provides methods for diagnosing mental disorders (e.g., psychotic disorders such as schizophrenia and mood disorders such as major depression disorder and bipolar disorder). The invention also provides methods of identifying modulators of such mental disorders as well as methods of using these modulators to treat patients suffering from such mental disorders.
摘要翻译： 本发明提供了用于诊断精神障碍（例如精神病性障碍如精神分裂症和情绪障碍如重性抑郁障碍和双相情感障碍）的方法。 本发明还提供鉴定这种精神障碍的调节剂的方法以及使用这些调节剂来治疗患有这种精神障碍的患者的方法。
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公开(公告)号：US20090233842A1
公开(公告)日：2009-09-17
申请号：US12093437
申请日：2006-11-13
申请人： Huda Akil , Stanley J. Watson , Simon J. Evans , Cortney Turner , Rene Bernard , Ilan Kerman , Robert C. Thompson , Margit Burmeister , Laura J. Scott , Fan Meng , Michael Boehnke , William E. Bunney, JR. , Marquis P. Vawter , Edward G. Jones , Prabhakara V. Choudary , Richard M. Myers , Alan F. Schatzberg , Jun Li , Devin Absher , Hiroaki Tomita
发明人： Huda Akil , Stanley J. Watson , Simon J. Evans , Cortney Turner , Rene Bernard , Ilan Kerman , Robert C. Thompson , Margit Burmeister , Laura J. Scott , Fan Meng , Michael Boehnke , William E. Bunney, JR. , Marquis P. Vawter , Edward G. Jones , Prabhakara V. Choudary , Richard M. Myers , Alan F. Schatzberg , Jun Li , Devin Absher , Hiroaki Tomita
CPC分类号： C12Q1/6883 , A61K38/03 , A61K38/10 , A61K38/1774 , A61K38/1825 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N2800/304
摘要： The present application relates to the treatment and diagnosis of mood disorders, including bipolar disorder, major depression disorder and schizophrenia. The invention provides novel diagnostic markers and assays, as well as research tools for the development and discovery of agents and compounds which are useful for treating patients who suffer from mental illness.
摘要翻译： 本申请涉及心理障碍的治疗和诊断，包括双相情感障碍，重症抑郁障碍和精神分裂症。 本发明提供了新的诊断标记和测定，以及用于开发和发现可用于治疗患有精神疾病的患者的药剂和化合物的研究工具。
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8.发明申请SNP DETECTION AND OTHER METHODS FOR CHARACTERIZING AND TREATING BIPOLAR DISORDER AND OTHER AILMENTS 审中-公开表征和处理双极性疾病及其他物质的SNP检测及其他方法公开(公告)号：US20080199866A1
公开(公告)日：2008-08-21
申请号：US11868456
申请日：2007-10-05
申请人： Huda Akil , Stanley J. Watson , Simon J. Evans , Cortney Turner , Rene Bernard , Ilan Kerman , Robert Thompson , Margit Burmeister , Laura J. Scott , Fan Meng , Michael Boehnke , William Bunney , Marquis Vawter , Edward Jones , Prabhakara V. Choudary , Richard Myers , Alan Schatzberg , Jun Li , Devin Absher
发明人： Huda Akil , Stanley J. Watson , Simon J. Evans , Cortney Turner , Rene Bernard , Ilan Kerman , Robert Thompson , Margit Burmeister , Laura J. Scott , Fan Meng , Michael Boehnke , William Bunney , Marquis Vawter , Edward Jones , Prabhakara V. Choudary , Richard Myers , Alan Schatzberg , Jun Li , Devin Absher
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present application relates to the use of SNPs and differential exon expression to characterize, diagnose or treat bipolar disorder and other mental illnesses, such as major depressive disorder and schizophrenia.
摘要翻译： 本申请涉及使用SNP和差异外显子表达来表征，诊断或治疗双相情感障碍和其他精神疾病，如重度抑郁障碍和精神分裂症。
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公开(公告)号：US07097835B2
公开(公告)日：2006-08-29
申请号：US10198003
申请日：2002-07-17
IPC分类号： A61K39/395 , C07K21/08
CPC分类号： C07K16/18 , A61K47/6825 , A61K47/6843 , A61K47/6849 , C07K16/28
摘要： The present invention provides immunoselective targeting agents that bind to transporters that are transiently accessible on the surface of neuronal cells, and that deliver compounds selectively to such cells. The invention provides methods of selectively killing, as well as methods of selectively promoting survival of, a neuronal cell.
摘要翻译： 本发明提供了与神经元细胞表面上瞬时可及的转运蛋白结合的免疫选择性靶向剂，并且将化合物选择性地递送至这些细胞。 本发明提供选择性杀伤的方法以及选择性促进神经元细胞存活的方法。
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