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    Treatment of neuropsychiatric disease with protease and neuraminidase inhibitors
    6.
    发明申请
    Treatment of neuropsychiatric disease with protease and neuraminidase inhibitors 审中-公开
    用蛋白酶和神经氨酸酶抑制剂治疗神经精神疾病

    公开(公告)号：US20060205650A1

    公开(公告)日：2006-09-14

    申请号：US11355257

    申请日：2006-02-14

    申请人： Marquis Vawter ,  William Freed

    发明人： Marquis Vawter ,  William Freed

    IPC分类号： A61K38/54 ,  A61K31/7008

    CPC分类号： G01N33/6896 ,  A61K31/551 ,  A61K31/7008 ,  A61K38/05 ,  A61K38/06 ,  A61K38/55 ,  A61K38/57 ,  A61K45/06 ,  G01N2800/52 ,  A61K2300/00

    摘要： The present invention provides a method of treating a neuropsychiatric disease characterized by an abnormally elevated level of a fragment of an isoform of a neural cell adhesion molecule, N-CAM, in the brain or cerebrospinal fluid of an affected human subject, comprising administering a therapeutically effective amount of at least one compound selected from the group consisting of protease inhibitors and neuraminidase inhibitors, whereby administering the compound to the subject treats the human subject. The present invention further provides a method of monitoring the efficacy of treatment with the method of the present invention. Moreover, the present invention provides a method of screening for compounds effective in treating neuropsychiatric disease associated with an abnormally elevated level of a fragment of a neural cell adhesion molecule in the cerebrospinal fluid of an affected human subject. Further provided are fragments of an isoform of N-CAM in the cerebrospinal fluid of human subjects.

    摘要翻译： 本发明提供一种治疗神经精神疾病的方法，其特征在于在受影响的人类受试者的脑或脑脊髓液中神经细胞粘附分子N-CAM的同种型的片段异常升高的水平，包括施用治疗 有效量的至少一种选自蛋白酶抑制剂和神经氨酸酶抑制剂的化合物，其中向受试者施用该化合物治疗人受试者。 本发明还提供了用本发明的方法监测治疗效果的方法。 此外，本发明提供一种筛选与受影响人类受试者的脑脊液中的神经细胞粘附分子的片段异常升高相关的神经精神疾病有效治疗的化合物的方法。 还提供了人受试者脑脊液中N-CAM同种型的片段。