公开(公告)号：US20060259308A1

公开(公告)日：2006-11-16

申请号：US11126615

申请日：2005-05-11

申请人： Hugh Browne ,  Frances Bruttin ,  Douglas Dean ,  Christopher Kenyon ,  Eleni Pratsinis ,  Walter Dyck

发明人： Hugh Browne ,  Frances Bruttin ,  Douglas Dean ,  Christopher Kenyon ,  Eleni Pratsinis ,  Walter Dyck

IPC分类号： G06Q99/00

CPC分类号： G06Q40/08 ,  G06Q10/0635

摘要： A method for production refactoring of a company comprises quantifying risks stemming from regulations, in particular from an introduction of new regulation. It further comprises identifying actions to take in order to reduce an exposure to risk, quantifying costs of said actions and determining a revenue at risk depending on a revenue and a probability of failure representing said risks. Furthermore, it comprises determining a sequence of actions for solving an improvement problem depending on said revenue at risk and said costs of said actions and profits reducing said revenue at risks and said costs of said actions and increasing said profits.

摘要翻译： 公司的生产重构方法包括量化法规所引起的风险，特别是引入新法规。 它进一步包括识别为了减少风险敞口而采取的行动，量化所述行为的成本，并根据代表所述风险的收益和失败概率确定风险收入。 此外，它包括根据所述风险收益确定用于解决改进问题的一系列动作，并且所述动作的所述成本和利润降低所述收入的风险以及所述动作的所述成本并增加所述利润。

公开(公告)号：US11423486B2

公开(公告)日：2022-08-23

申请号：US11126615

申请日：2005-05-11

申请人： Hugh Browne ,  Frances Bruttin ,  Douglas Dean ,  Christopher M. Kenyon ,  Eleni Pratsinis ,  Walter Van Dyck

发明人： Hugh Browne ,  Frances Bruttin ,  Douglas Dean ,  Christopher M. Kenyon ,  Eleni Pratsinis ,  Walter Van Dyck

IPC分类号： G06Q40/08 ,  G06Q10/06

摘要： A method for production refactoring of a company comprises quantifying risks stemming from regulations, in particular from an introduction of new regulation. It further comprises identifying actions to take in order to reduce an exposure to risk, quantifying costs of said actions and determining a revenue at risk depending on a revenue and a probability of failure representing said risks. Furthermore, it comprises determining a sequence of actions for solving an improvement problem depending on said revenue at risk and said costs of said actions and profits reducing said revenue at risks and said costs of said actions and increasing said profits.

公开(公告)号：US20110243898A1

公开(公告)日：2011-10-06

申请号：US12951678

申请日：2010-11-22

申请人： Douglas Dean ,  Yongqing Liu

发明人： Douglas Dean ,  Yongqing Liu

IPC分类号： A61K35/12 ,  C12N5/0775

CPC分类号： C12N5/0696 ,  A61D19/04 ,  C12N2501/405 ,  C12N2506/1307

摘要： Provided are methods for producing a reprogrammed fibroblast. The methods can include growing a plurality of fibroblasts in monolayer culture to confluency; and disrupting the monolayer culture to place at least a fraction of the plurality of fibroblasts into suspension culture under conditions sufficient to form one or more embryoid body-like spheres, wherein the one or more embryoid body-like spheres comprise one or more reprogrammed fibroblasts that express one or more markers not expressed by a fibroblast growing in the monolayer culture prior to the disrupting step. Also provided are reprogrammed fibroblasts produced by the disclosed methods, formulations that include reprogrammed fibroblasts, and methods for treating an injury to a tissue in a subject by administering to a subject in need thereof a composition of reprogrammed fibroblast cells in a pharmaceutically acceptable carrier.

摘要翻译： 提供了生产重编程成纤维细胞的方法。 所述方法可以包括在单层培养物中培养多个成纤维细胞以达到融合; 并且破坏所述单层培养物以使所述多个成纤维细胞的至少一部分在足以形成一个或多个类胚体样球体的条件下进行悬浮培养，其中所述一个或多个类胚体样球体包含一个或多个重编程成纤维细胞， 表达在破坏步骤之前在单层培养物中生长的成纤维细胞未表达的一种或多种标记。 还提供了通过所公开的方法制备的重新编程的成纤维细胞，其包括重编程的成纤维细胞的制剂，以及通过向有需要的受试者施用药学上可接受的载体中重编程的成纤维细胞的组合物来治疗受试者的组织的损伤的方法。

公开(公告)号：US20130312130A1

公开(公告)日：2013-11-21

申请号：US13976879

申请日：2011-09-23

申请人： Douglas Dean ,  Yongqing Liu

发明人： Douglas Dean ,  Yongqing Liu

IPC分类号： C12N5/074 ,  A61D19/04

CPC分类号： C12N5/0696 ,  A61D19/04 ,  C12N2501/405 ,  C12N2506/1307

摘要： Provided are methods for producing a reprogrammed fibroblast or epithelial cell. The methods include growing a plurality of fibroblasts or epithelial cells in monolayer culture to confluency; and disrupting the monolayer culture to place at least a fraction of the plurality of fibroblasts or epithelial cells into suspension culture under conditions sufficient to form one or more embryoid body-like spheres, wherein the one or more embryoid body-like spheres comprise one or more reprogrammed fibroblasts or epithelial cells that express one or more markers not expressed prior to the disrupting step. Also provided are reprogrammed fibroblasts or epithelial cells produced by the disclosed methods, formulations that include reprogrammed fibroblasts or epithelial cells, methods for using the reprogrammed fibroblasts or epithelial cells, methods for producing chimeric non-human mammals that include one or more sphere-induced Pluripotent Cells (siPS), and chimeric non-human mammals produced thereby.

摘要翻译： 提供了用于产生重编程的成纤维细胞或上皮细胞的方法。 所述方法包括在单层培养物中培养多个成纤维细胞或上皮细胞以融合; 以及破坏所述单层培养物，以将所述多个成纤维细胞或上皮细胞的至少一部分置于足以形成一个或多个类胚体样球体的条件下进行悬浮培养，其中所述一个或多个类胚体样球体包含一个或多个 重编程的成纤维细胞或上皮细胞，其表达在破坏步骤之前未表达的一种或多种标志物。 还提供了通过公开的方法产生的重编程成纤维细胞或上皮细胞，包括重编程的成纤维细胞或上皮细胞的制剂，使用重编程的成纤维细胞或上皮细胞的方法，用于生产嵌合非人哺乳动物的方法，其包括一种或多种球引起的多能 细胞（siPS）和由此产生的嵌合非人哺乳动物。

公开(公告)号：US20130269364A1

公开(公告)日：2013-10-17

申请号：US13444375

申请日：2012-04-11

申请人： Bryan Wesley Romig ,  Derrick Simons ,  Douglas Dean

发明人： Bryan Wesley Romig ,  Derrick Simons ,  Douglas Dean

IPC分类号： F02C9/26 ,  F02C7/00

CPC分类号： F02C7/232 ,  F01D21/14 ,  F02C7/22 ,  F02C9/28 ,  F02D2041/225 ,  F05D2260/80

摘要： Embodiments can provide systems and methods for detecting fuel leaks in gas turbine engines. According to one embodiment, there is disclosed a method for detecting a fuel leak in a gas turbine engine. The method may include adjusting a control valve to correspond with a desired fuel flow. The method may also include determining an actual fuel flow based at least in part on an upstream pressure in a fuel manifold and one or more gas turbine engine parameters. The method may also include comparing the desired fuel flow with the actual fuel flow. Moreover, the method may include determining a difference between the desired fuel flow and the actual fuel flow, wherein the difference indicates a fuel leak.

摘要翻译： 实施例可以提供用于检测燃气涡轮发动机中的燃料泄漏的系统和方法。 根据一个实施例，公开了一种用于检测燃气涡轮发动机中的燃料泄漏的方法。 该方法可以包括调节控制阀以对应于期望的燃料流。 该方法还可以包括至少部分地基于燃料歧管中的上游压力和一个或多个燃气涡轮发动机参数来确定实际燃料流。 该方法还可以包括将所需燃料流与实际燃料流进行比较。 此外，该方法可以包括确定期望燃料流量与实际燃料流量之间的差异，其中差值表示燃料泄漏。

公开(公告)号：US20070253443A1

公开(公告)日：2007-11-01

申请号：US11412455

申请日：2006-04-27

申请人： Douglas Dean ,  Craig Riley

发明人： Douglas Dean ,  Craig Riley

IPC分类号： H04J3/22

CPC分类号： H04M11/062

摘要： The present disclosure provides a system, method and computer-readable medium for providing a network service. In one aspect, the disclosure provides a system for providing a network service that includes a network device for providing the network service over a network loop using Symmetric High Bit Rate Digital Subscriber Loop (G.SHDSL) as a transport mechanism over the network loop; and a network-capable access device that terminates the network loop.

摘要翻译： 本公开提供了一种用于提供网络服务的系统，方法和计算机可读介质。 一方面，本公开提供了一种用于提供网络服务的系统，该网络服务包括网络设备，用于通过网络环路提供网络服务，使用对称高比特率数字用户环路（G.SHDSL）作为网络环路上的传输机制; 以及终止网络环路的具有网络能力的接入设备。

公开(公告)号：US09140189B2

公开(公告)日：2015-09-22

申请号：US13444375

申请日：2012-04-11

申请人： Bryan Wesley Romig ,  Derrick Simons ,  Douglas Dean

发明人： Bryan Wesley Romig ,  Derrick Simons ,  Douglas Dean

IPC分类号： F02C9/26 ,  F02C7/232 ,  F02C9/28 ,  F02C7/22 ,  F02D41/22 ,  F01D21/14

CPC分类号： F02C7/232 ,  F01D21/14 ,  F02C7/22 ,  F02C9/28 ,  F02D2041/225 ,  F05D2260/80

摘要： Embodiments can provide systems and methods for detecting fuel leaks in gas turbine engines. According to one embodiment, there is disclosed a method for detecting a fuel leak in a gas turbine engine. The method may include adjusting a control valve to correspond with a desired fuel flow. The method may also include determining an actual fuel flow based at least in part on an upstream pressure in a fuel manifold and one or more gas turbine engine parameters. The method may also include comparing the desired fuel flow with the actual fuel flow. Moreover, the method may include determining a difference between the desired fuel flow and the actual fuel flow, wherein the difference indicates a fuel leak.

摘要翻译： 实施例可以提供用于检测燃气涡轮发动机中的燃料泄漏的系统和方法。 根据一个实施例，公开了一种用于检测燃气涡轮发动机中的燃料泄漏的方法。 该方法可以包括调节控制阀以对应于期望的燃料流。 该方法还可以包括至少部分地基于燃料歧管中的上游压力和一个或多个燃气涡轮发动机参数来确定实际燃料流。 该方法还可以包括将所需燃料流与实际燃料流进行比较。 此外，该方法可以包括确定期望燃料流量与实际燃料流量之间的差异，其中差值表示燃料泄漏。

公开(公告)号：US20070147420A1

公开(公告)日：2007-06-28

申请号：US11316276

申请日：2005-12-22

申请人： Douglas Dean

发明人： Douglas Dean

IPC分类号： H04J3/16 ,  H04L12/56 ,  H04L12/28 ,  H04J3/22

CPC分类号： H04L12/2856 ,  H04L12/2874

摘要： The present disclosure describes a system and apparatus for providing a network service, such as Frame Relay. The apparatus transmits the service to the network utilizing a G.SHDSL transmission standard; converts data between data utilizing a DS-1 transmission standard and data utilizing a G.SHDSL transmission standard; stores a parameter relating to the network service (e.g., bandwidth); and provides access to the parameter to the network. The apparatus further includes a database for storing the parameters relating to the network service, and a processor for running a program, such as an emulator, to convert the data. The processor also may set an operation in response to a signal received from the network, including synchronizing a clock in the apparatus with a network clock, changing a bandwidth of the apparatus, and upgrading a computer program at the apparatus.

摘要翻译： 本公开描述了用于提供诸如帧中继的网络服务的系统和装置。 该装置利用G.SHDSL传输标准向网络发送业务; 使用DS-1传输标准的数据和利用G.SHDSL传输标准的数据之间转换数据; 存储与网络服务相关的参数（例如，带宽）; 并提供对网络参数的访问。 该装置还包括用于存储与网络服务相关的参数的数据库，以及用于运行诸如仿真器的程序以转换数据的处理器。 处理器还可以响应于从网络接收的信号来设置操作，包括使设备中的时钟与网络时钟同步，改变设备的带宽以及在设备处升级计算机程序。

公开(公告)号：US20070029273A1

公开(公告)日：2007-02-08

申请号：US11471804

申请日：2006-06-21

申请人： Douglas Dean ,  Steven Kessell

发明人： Douglas Dean ,  Steven Kessell

IPC分类号： A47F5/00

CPC分类号： A47F5/0068 ,  A47B96/02

摘要： A product storage and display structure includes uprights, at least one shelf, and at least one shelf ledge. The shelf ledge includes first and second opposite ends, each end adapted to be removably coupled to an upright of the product storage and display structure. A barrier portion extends upwardly from the base portion, wherein when the base portion is coupled to the uprights, the barrier portion extends to a location proximate and at a higher elevation than the shelf of the product storage and display structure.

摘要翻译： 产品存储和显示结构包括立柱，至少一个货架和至少一个搁板。 搁板凸缘包括第一和第二相对端，每个端部适于可拆卸地联接到产品存储和显示结构的立柱上。 阻挡部分从基部向上延伸，其中当基部连接到立柱时，阻挡部分延伸到与产品存储和显示结构的架子相邻且高于高度的位置处。