公开(公告)号：US4480036A

公开(公告)日：1984-10-30

申请号：US176527

申请日：1980-08-08

申请人： Hugh W. Morgan ,  Roy M. Daniel ,  Donald A. Cowan ,  Christopher W. Hickey

发明人： Hugh W. Morgan ,  Roy M. Daniel ,  Donald A. Cowan ,  Christopher W. Hickey

IPC分类号： C12N1/00 ,  C12N1/20 ,  C12N9/52 ,  C12N11/02 ,  C12N11/06 ,  C12N11/10 ,  C12N11/12 ,  C12N11/14

CPC分类号： C12R1/01 ,  C12N11/10 ,  C12N11/14 ,  C12N9/52 ,  Y10S435/815 ,  Y10S435/822

摘要： The invention relates to an extremely thermophilic bacterium, Thermus T-351, and a thermophilic protease, Caldolysin, derived therefrom. The bacterium cells are Gram negative, non-sporulating rods. Its natural environment is a hot pool at 79.degree..+-.4.degree. C. The protease is stable at temperatures up to 75.degree. C. at a pH range of 4 to 12. It is most active at temperatures of 65.degree. C. to 85.degree. C. but retains at least some activity at lower temperatures.

公开(公告)号：US4442214A

公开(公告)日：1984-04-10

申请号：US176528

申请日：1980-08-08

申请人： Hugh W. Morgan ,  Roy M. Daniel

发明人： Hugh W. Morgan ,  Roy M. Daniel

IPC分类号： C12N1/00 ,  C12N1/20 ,  C12N9/52 ,  C12N11/02 ,  C12N11/06 ,  C12N11/10 ,  C12N11/12 ,  C12N11/14 ,  C12N9/50

CPC分类号： C12R1/01 ,  C12N11/10 ,  C12N11/14 ,  C12N9/52 ,  Y10S435/815 ,  Y10S435/822

摘要： The invention relates to an extremely thermophilic bacterium, THERMUS T-351, and a thermophilic protease, CALDOLYSIN, derived therefrom. The bacterium cells are Gram negative, non-sporulating rods. Its natural environment is a hot pool at 79.degree..+-.4.degree. C. The protease is stable at temperatures up to 75.degree. C. at a pH range of 4 to 12. It is most active at temperatures of 65.degree. C. to 85.degree. C. but retains at least some activity at lower temperatures.

摘要翻译： 本发明涉及一种非常嗜热的细菌，THERMUS T-351，以及由此衍生的嗜热蛋白酶CALDOLYSIN。 细菌细胞是革兰氏阴性，非孢子棒。 其自然环境是79℃+/- 4℃的热水池。蛋白酶在高达75℃的温度下在4至12的pH范围内是稳定的。它在65℃至+ 但在较低温度下保留至少一些活性。

公开(公告)号：US4473646A

公开(公告)日：1984-09-25

申请号：US253112

申请日：1981-04-10

申请人： Graeme R. Guy ,  Hugh W. Morgan ,  Roy M. Daniel

发明人： Graeme R. Guy ,  Hugh W. Morgan ,  Roy M. Daniel

IPC分类号： C12N9/82 ,  C12N1/20

CPC分类号： C12N9/82 ,  Y10S435/815 ,  Y10S435/822

摘要： There is described a method of separating an asparaginase rich fraction from a thermophilic microoganism and then to divide this fraction into its D- and L-asparaginases. Substantially pure crystals of the D-asparaginase were obtained.

摘要翻译： 描述了从嗜热微生物学分离富含天冬酰胺酶的部分，然后将其分成其D-和L-天冬酰胺酶的方法。 得到基本纯的D-天冬酰胺酶晶体。