公开(公告)号：US20240075100A1

公开(公告)日：2024-03-07

申请号：US18506575

申请日：2023-11-10

申请人： ILIAS BIOLOGICS INC.

发明人： Chulhee Choi ,  Nambin Yim ,  Won Do Heo ,  Seung-Wook Ryu ,  Hojun Choi ,  Kyungsun Choi

IPC分类号： A61K38/17 ,  A61K47/69 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  C12N15/62 ,  C12N15/85 ,  C12P21/02

CPC分类号： A61K38/177 ,  A61K47/6917 ,  C07K14/705 ,  C07K14/70596 ,  C07K16/18 ,  C07K16/28 ,  C12N15/62 ,  C12N15/85 ,  C12P21/02 ,  A61K38/00 ,  C07K2317/80 ,  C07K2319/03 ,  C07K2319/70

摘要： The present invention relates to a method for the mass-production of exosome comprising a cargo protein, a vector for preparing the exosome, exosome including a cargo protein prepared by the method, and a method for loading the cargo protein to cytosol by using the exosome prepared thereby. According to the method for preparing an exosome comprising a cargo protein provided by the present invention, the exosome loaded with a cargo protein can be produced with a high yield, so that it can be used broadly in the treatment of disease using the exosome.

公开(公告)号：US11872193B2

公开(公告)日：2024-01-16

申请号：US16887029

申请日：2020-05-29

申请人： ILIAS BIOLOGICS INC.

发明人： Chulhee Choi ,  Nambin Yim ,  Won Do Heo ,  Seung-Wook Ryu ,  Hojun Choi ,  Kyungsun Choi

IPC分类号： C12N15/62 ,  C12N15/85 ,  A61K47/69 ,  A61K38/17 ,  C07K16/28 ,  C12P21/02 ,  C07K16/18 ,  C07K14/705 ,  A61K38/00

CPC分类号： A61K38/177 ,  A61K47/6917 ,  C07K14/705 ,  C07K14/70596 ,  C07K16/18 ,  C07K16/28 ,  C12N15/62 ,  C12N15/85 ,  C12P21/02 ,  A61K38/00 ,  C07K2317/80 ,  C07K2319/03 ,  C07K2319/70

摘要： The present invention relates to a method for the mass-production of exosome comprising a cargo protein, a vector for preparing the exosome, exosome including a cargo protein prepared by the method, and a method for loading the cargo protein to cytosol by using the exosome prepared thereby. According to the method for preparing an exosome comprising a cargo protein provided by the present invention, the exosome loaded with a cargo protein can be produced with a high yield, so that it can be used broadly in the treatment of disease using the exosome.

公开(公告)号：US11696939B2

公开(公告)日：2023-07-11

申请号：US17138864

申请日：2020-12-30

申请人： ILIAS Biologics Inc ,  ILIAS Therapeutics, Inc.

发明人： Chulhee Choi ,  Kyungsun Choi ,  Ramkumar Menon

IPC分类号： A61K35/12 ,  A61K38/17 ,  A61K47/69 ,  A61P15/06 ,  A61K38/095 ,  A61K9/127 ,  A61K31/137 ,  A61K31/4025 ,  A61K31/405 ,  A61K31/43 ,  A61K31/4422 ,  A61K31/545 ,  A61K31/57 ,  A61K31/7048 ,  A61K33/06 ,  A61K38/16 ,  A61K38/45 ,  A61K38/51

CPC分类号： A61K38/1738 ,  A61K9/127 ,  A61K31/137 ,  A61K31/405 ,  A61K31/4025 ,  A61K31/43 ,  A61K31/4422 ,  A61K31/545 ,  A61K31/57 ,  A61K31/7048 ,  A61K33/06 ,  A61K38/095 ,  A61K38/164 ,  A61K38/168 ,  A61K38/1709 ,  A61K38/1774 ,  A61K38/45 ,  A61K38/51 ,  A61K47/6911 ,  A61P15/06

摘要： The present invention is related to compositions containing extracellular vesicles (exosomes) and methods of using the same for increasing lifespan of fetus, viability of fetus, or viability of newborn, for treating inflammation in uterus and/or fetus, for delaying preterm birth, or for treating a condition related to inflammation in uterus and/or fetus, wherein the extracellular vesicles comprising a nuclear factor kappa beta (NF-κB) inhibitor and a photo-specific binding protein.

公开(公告)号：US20210299215A1

公开(公告)日：2021-09-30

申请号：US17227359

申请日：2021-04-11

申请人： Ilias Biologics Inc.

发明人： Chulhee Choi ,  Kyungsun Choi ,  Jae-Kwang Yoo

IPC分类号： A61K38/17 ,  A61P13/12 ,  A61K45/06 ,  A61K47/62

摘要： The present disclosure relates to methods for treating acute kidney injury using exosome containing NF-κB inhibitors. The present disclosure relates to methods for treating diseases induced by sepsis using exosome containing NF-κB inhibitor. The present disclosure also is related to methods for treating respiratory diseases, such as viral respiratory diseases, using exosome containing NF-κB inhibitor.