公开(公告)号：US20240141427A1

公开(公告)日：2024-05-02

申请号：US18373620

申请日：2023-09-27

申请人： ILLUMINA, INC.

发明人： Misha Golynskiy ,  Rahman Rahman Pour ,  Jiawen Li ,  Ryan Craig ,  Hamed Tabatabaei Ghomi ,  Saurabh Nirantar ,  Hsu Myat Noe ,  Lin Hui Chang ,  Yvonne Devadas ,  Jing Wen Lim ,  Kay Klausing ,  Humberto Rojo ,  Eric Murtfeldt ,  Chris Garcia

IPC分类号： C12Q1/6874 ,  C12N9/12

CPC分类号： C12Q1/6874 ,  C12N9/1252 ,  C12Y207/07007

摘要： Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low error rate, low phasing rate, or increased incorporation rate for a second generation ffN under reduced incorporation times, as well as methods and kits using the same.