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公开(公告)号：US10995324B2
公开(公告)日：2021-05-04
申请号：US16403976
申请日：2019-05-06
申请人： Illumina, Inc.
发明人： Misha Golynskiy , Molly He , Michael Previte , BeiBei Wang , Sergio Peisajovich
摘要： Presented herein are methods and compositions for thermostable DNA polymerases that may be used to improve the PCR process and to improve the results obtained when using a thermostable DNA polymerase in other recombinant techniques such as DNA sequencing, nick-translation, and reverse transcription.
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公开(公告)号：US10329545B2
公开(公告)日：2019-06-25
申请号：US15526386
申请日：2015-11-13
申请人： Illumina, Inc.
发明人： Misha Golynskiy , Molly He , Michael Previte , BeiBei Wang , Sergio Peisajovich
摘要： Presented herein are methods and compositions for thermostable DNA polymerases that may be used to improve the PCR process and to improve the results obtained when using a thermostable DNA polymerase in other recombinant techniques such as DNA sequencing, nick-translation, and reverse transcription.
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公开(公告)号：US20190112730A1
公开(公告)日：2019-04-18
申请号：US16158120
申请日：2018-10-11
申请人： Illumina, Inc.
发明人： Molly He , Michael Previte , Misha Golynskiy , Matthew William Kellinger , Sergio Peisajovich , Jonathan Mark Boutell
摘要： A method of characterizing candidate agents including steps of (a) providing a library of candidate agents attached to nucleic acid tags; (b) contacting the library with a solid support to attach the candidate agents to the solid support, whereby an array of candidate agents is formed; (c) contacting the array with a screening agent, wherein one or more candidate agents in the array react with the screening agent; (d) detecting the array to determine that at least one candidate agent in the array reacts with the screening agent; (e) sequencing the nucleic acid tag to determine the tag sequences attached to candidate agents in the array; and (f) identifying the at least one candidate agent in the array that reacts with the screening agent based on the tag sequence that is attached to the at least one candidate agent.
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公开(公告)号：US20240141427A1
公开(公告)日：2024-05-02
申请号：US18373620
申请日：2023-09-27
申请人： ILLUMINA, INC.
发明人： Misha Golynskiy , Rahman Rahman Pour , Jiawen Li , Ryan Craig , Hamed Tabatabaei Ghomi , Saurabh Nirantar , Hsu Myat Noe , Lin Hui Chang , Yvonne Devadas , Jing Wen Lim , Kay Klausing , Humberto Rojo , Eric Murtfeldt , Chris Garcia
IPC分类号： C12Q1/6874 , C12N9/12
CPC分类号： C12Q1/6874 , C12N9/1252 , C12Y207/07007
摘要： Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low error rate, low phasing rate, or increased incorporation rate for a second generation ffN under reduced incorporation times, as well as methods and kits using the same.
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公开(公告)号：US20230212534A1
公开(公告)日：2023-07-06
申请号：US18085674
申请日：2022-12-21
发明人： Misha Golynskiy , Seth McDonald , Saurabh Nirantar , Matthew Kellinger , Michael Previte , Sergio Peisajovich , Molly He
CPC分类号： C12N9/1241 , C12N1/20
摘要： Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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公开(公告)号：US20230047225A1
公开(公告)日：2023-02-16
申请号：US17829866
申请日：2022-06-01
发明人： Misha Golynskiy , Mariko Matsuura , Saurabh Nirantar , Hamed Tabatabaei Ghomi , Seth McDonald , Ryan Craig , Sergio Peisajovich , Kyrie Johnson , Kay Klausing , Eric Murtfeldt , Alexandra Exner
IPC分类号： C12N9/12 , C12Q1/6874
摘要： Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low pre-phasing rates when using ambiently stored polymerases, as well as methods and kits using the same.
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公开(公告)号：US12104182B2
公开(公告)日：2024-10-01
申请号：US18120639
申请日：2023-03-13
发明人： Kay Klausing , Hamed Tabatabaei Ghomi , Misha Golynskiy , Saurabh Nirantar , Seth McDonald , Sergio Peisajovich
IPC分类号： C12N9/12
CPC分类号： C12N9/1252 , C12Y207/07007
摘要： Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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公开(公告)号：US20230357731A1
公开(公告)日：2023-11-09
申请号：US18120639
申请日：2023-03-13
发明人： Kay Klausing , Hamed Tabatabaei Ghomi , Misha Golynskiy , Saurabh Nirantar , Seth McDonald , Sergio Peisajovich
IPC分类号： C12N9/12
CPC分类号： C12N9/1252 , C12Y207/07007
摘要： Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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公开(公告)号：US11560552B2
公开(公告)日：2023-01-24
申请号：US17397003
申请日：2021-08-09
发明人： Misha Golynskiy , Seth McDonald , Saurabh Nirantar , Matthew Kellinger , Michael Previte , Sergio Peisajovich , Molly He
摘要： Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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公开(公告)号：US20220056424A1
公开(公告)日：2022-02-24
申请号：US17397003
申请日：2021-08-09
发明人： Misha Golynskiy , Seth McDonald , Saurabh Nirantar , Matthew Kellinger , Michael Previte , Sergio Peisajovich , Molly He
IPC分类号： C12N9/12
摘要： Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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