公开(公告)号：US12077789B2

公开(公告)日：2024-09-03

申请号：US17829866

申请日：2022-06-01

Applicant: ILLUMINA, INC.

Inventor： Misha Golynskiy ,  Mariko Matsuura ,  Saurabh Nirantar ,  Hamed Tabatabaei Ghomi ,  Seth McDonald ,  Ryan Craig ,  Sergio Peisajovich ,  Kyrie Johnson ,  Kay Klausing ,  Eric Murtfeldt ,  Alexandra Exner

IPC: C12N9/12 ,  C12Q1/6874

CPC classification number: C12N9/1252 ,  C12Q1/6874 ,  C12Y207/07007

Abstract: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low pre-phasing rates when using ambiently stored polymerases, as well as methods and kits using the same.

公开(公告)号：US20240141427A1

公开(公告)日：2024-05-02

申请号：US18373620

申请日：2023-09-27

Applicant: ILLUMINA, INC.

Inventor： Misha Golynskiy ,  Rahman Rahman Pour ,  Jiawen Li ,  Ryan Craig ,  Hamed Tabatabaei Ghomi ,  Saurabh Nirantar ,  Hsu Myat Noe ,  Lin Hui Chang ,  Yvonne Devadas ,  Jing Wen Lim ,  Kay Klausing ,  Humberto Rojo ,  Eric Murtfeldt ,  Chris Garcia

IPC: C12Q1/6874 ,  C12N9/12

CPC classification number: C12Q1/6874 ,  C12N9/1252 ,  C12Y207/07007

Abstract: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low error rate, low phasing rate, or increased incorporation rate for a second generation ffN under reduced incorporation times, as well as methods and kits using the same.

公开(公告)号：US20230047225A1

公开(公告)日：2023-02-16

申请号：US17829866

申请日：2022-06-01

Applicant: ILLUMINA, INC. ,  ILLUMINA CAMBRIDGE LIMITED ,  ILLUMINA SINGAPORE PTE. LTD.

Inventor： Misha Golynskiy ,  Mariko Matsuura ,  Saurabh Nirantar ,  Hamed Tabatabaei Ghomi ,  Seth McDonald ,  Ryan Craig ,  Sergio Peisajovich ,  Kyrie Johnson ,  Kay Klausing ,  Eric Murtfeldt ,  Alexandra Exner

IPC: C12N9/12 ,  C12Q1/6874

Abstract: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low pre-phasing rates when using ambiently stored polymerases, as well as methods and kits using the same.