公开(公告)号：US20220082569A1

公开(公告)日：2022-03-17

申请号：US17459459

申请日：2021-08-27

申请人： ILLUMINA, INC. ,  ILLUMINA SINGAPORE PTE. LTD.

发明人： Rigo Pantoja ,  Daniel Ortiz ,  Xiangyuan Yang ,  Yin Nah Teo ,  Eric Vermaas ,  Allen Eckhardt

IPC分类号： G01N33/68 ,  C12Q1/6869

摘要： A method is provided for detecting an element. The method includes coupling an element-sugar complex to a substrate. The element-sugar complex includes an element coupled to a sugar. The method includes coupling a lectin to the sugar; detecting the lectin; and detecting the element using at least the detection of the lectin. A system is provided that includes a substrate, and an element-sugar complex coupled to the substrate. The element-sugar complex includes an element coupled to a sugar. The system includes a lectin coupled to the sugar; and detection circuitry to detect the element using at least detection of the lectin.

公开(公告)号：US20210087613A1

公开(公告)日：2021-03-25

申请号：US17026069

申请日：2020-09-18

申请人： ILLUMINA, INC.

发明人： Darren Segale ,  Fiona E. Black ,  Jeffrey Dennis Brodin ,  Lorenzo Berti ,  Siew Hong Leong ,  Jeffrey S. Fisher ,  Allen Eckhardt ,  Rui Zhang ,  Yin Nah Teo

IPC分类号： C12Q1/6816 ,  C12Q1/6837 ,  C12Q1/6874

摘要： Some embodiments provided herein include methods and compositions for the detection of target ligands on an array. In some embodiments, a capture probe specifically binds to a target ligand from a sample, the location of a bead comprising the capture probe in an array is determined, and the bead is decoded to identify the capture probe and the sample. In some embodiments, a barcode is indicative of a capture probe attached to a bead; and an index is indicative of a subpopulation of beads. Some embodiments relate to sequencing target polynucleotides from several different nucleic acids samples on a bead array.