公开(公告)号：US20190010483A1

公开(公告)日：2019-01-10

申请号：US16137925

申请日：2018-09-21

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Pei-Yi TSAI ,  Chih-Hung CHEN ,  Yi-Hung LIN ,  Chih-Chieh HUANG ,  Hsin-Hsin SHEN ,  Liang-Yin KE ,  Chu-Huang CHEN

IPC: C12N11/12 ,  C12N11/14 ,  C12N11/10 ,  A61M1/34 ,  C12M1/00

Abstract: A method for ex vivo treating blood or plasma is provided. The method includes (a) ex vivo contacting a blood or plasma with an enzyme composition to react the enzyme composition with the blood or plasma, wherein the enzyme composition is capable of eliminating electronegative low-density lipoprotein from the blood or plasma by the activity of the enzyme composition, and the enzyme composition is selected from a group consisting of: a first enzyme for eliminating a glycan residue of an electronegative low-density lipoprotein (LDL); a second enzyme for eliminating ceramide carried by a electronegative low-density lipoprotein (LDL); and a combination thereof; and (b) terminating contact between the blood or plasma and the enzyme composition to terminate the reaction of the enzyme composition with the blood or plasma.

公开(公告)号：US20170044516A1

公开(公告)日：2017-02-16

申请号：US14984938

申请日：2015-12-30

Applicant: Industrial Technology Research Institute

Inventor： Pei-Yi Tsai ,  Chih-Hung CHEN ,  Yi-Hung LIN ,  Chih-Chieh HUANG ,  Hsin-Hsin SHEN ,  Liang-Yin KE ,  Chu-Huang CHEN

IPC: C12N11/12 ,  A61M1/34 ,  C12M1/00

CPC classification number: C12N11/12 ,  A61M1/3486 ,  A61M2202/08 ,  C12M45/09 ,  C12N11/10 ,  C12N11/14

Abstract: The present disclosure provides a biochemistry reactive material, including a substrate and an enzyme composition immobilized on the substrate. The enzyme composition is selected from a group consisting of a first enzyme, a second enzyme, and a combination thereof. The first enzyme is used for eliminating a glycan residue of an electronegative low-density lipoprotein (electronegative LDL). The second enzyme is used for eliminating ceramide carried by an electronegative low-density lipoprotein. The biochemistry reactive material is capable of eliminating electronegative low-density lipoprotein.

Abstract translation: 本公开提供了生物化学反应性材料，其包括固定在基材上的底物和酶组合物。 酶组合物选自第一酶，第二酶及其组合。 第一种酶用于消除电负性低密度脂蛋白（电负性LDL）的聚糖残基。 第二种酶用于消除由负电性低密度脂蛋白携带的神经酰胺。 生物化学反应性材料能够消除电负性低密度脂蛋白。