公开(公告)号：US20190010483A1

公开(公告)日：2019-01-10

申请号：US16137925

申请日：2018-09-21

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Pei-Yi TSAI ,  Chih-Hung CHEN ,  Yi-Hung LIN ,  Chih-Chieh HUANG ,  Hsin-Hsin SHEN ,  Liang-Yin KE ,  Chu-Huang CHEN

IPC: C12N11/12 ,  C12N11/14 ,  C12N11/10 ,  A61M1/34 ,  C12M1/00

Abstract: A method for ex vivo treating blood or plasma is provided. The method includes (a) ex vivo contacting a blood or plasma with an enzyme composition to react the enzyme composition with the blood or plasma, wherein the enzyme composition is capable of eliminating electronegative low-density lipoprotein from the blood or plasma by the activity of the enzyme composition, and the enzyme composition is selected from a group consisting of: a first enzyme for eliminating a glycan residue of an electronegative low-density lipoprotein (LDL); a second enzyme for eliminating ceramide carried by a electronegative low-density lipoprotein (LDL); and a combination thereof; and (b) terminating contact between the blood or plasma and the enzyme composition to terminate the reaction of the enzyme composition with the blood or plasma.

公开(公告)号：US20190194137A1

公开(公告)日：2019-06-27

申请号：US16206000

申请日：2018-11-30

Applicant: Industrial Technology Research Institute

Inventor： Chih-Hung CHEN ,  Yi-Hsun CHEN ,  Jui-Wen HUANG ,  Kuo-Kuei HUANG ,  Chih-Peng LIU ,  Chrong-Shiong HWANG

IPC: C07D217/02

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof is provided. In formula (I), Ar is indazole, 5-isoquinoline, 6-isoquinoline, or their N-oxide. X is —C(═Z)—, wherein Z is N—CN, NH, NR4, NCOR4, NCONR4R5, NCO-aryl, S, or O. Y and J are independently H, alkyl, aryl, aminoalkyl, —NH2, —CN, —OH, —O-alkyl, —O-aryl, —COOH, —COOR4, —CONHR4, —CONHCH2-aryl, —CONR4CH2-aryl, —NHCOR4, halogen, halogened alkyl, -alkyl-OR4, -alkyl-ONO2, alkyl-ONO2, —OCOOR4, —O(C═O)-aryl, —CHR4OH, —CH2OH, —CH2O(C═O)-aryl, —CH2O(C═O)—R4, —CHR4O(C═O)-aryl, —CHR4O(C═O)—R4, unsaturated carboxylic ester, substituted alkynyl, —NHSO2R4, —SO2R4, —SO2NHR4, or —SO2NR4R5, or Y and J bond together to form a carbocylic or aromatic ring, wherein R4 and R5 are independently H, substituted C1-C6 alkyl, substituted aryl, cycloalkyl, alkylaryl, -alkyl-NR6R7, —S(O)0-2-(alkyl-NR6R7). R1, R2 and R3 are H, C1-C6 alkyl, cycloalkyl, aryl, alkylaryl, alkylheteroaryl, alkylheterocycle, wherein any one thereof is optionally substituted with one or more of OH, NO2, or NR8R9.

公开(公告)号：US20170044516A1

公开(公告)日：2017-02-16

申请号：US14984938

申请日：2015-12-30

Applicant: Industrial Technology Research Institute

Inventor： Pei-Yi Tsai ,  Chih-Hung CHEN ,  Yi-Hung LIN ,  Chih-Chieh HUANG ,  Hsin-Hsin SHEN ,  Liang-Yin KE ,  Chu-Huang CHEN

IPC: C12N11/12 ,  A61M1/34 ,  C12M1/00

CPC classification number: C12N11/12 ,  A61M1/3486 ,  A61M2202/08 ,  C12M45/09 ,  C12N11/10 ,  C12N11/14

Abstract: The present disclosure provides a biochemistry reactive material, including a substrate and an enzyme composition immobilized on the substrate. The enzyme composition is selected from a group consisting of a first enzyme, a second enzyme, and a combination thereof. The first enzyme is used for eliminating a glycan residue of an electronegative low-density lipoprotein (electronegative LDL). The second enzyme is used for eliminating ceramide carried by an electronegative low-density lipoprotein. The biochemistry reactive material is capable of eliminating electronegative low-density lipoprotein.

Abstract translation: 本公开提供了生物化学反应性材料，其包括固定在基材上的底物和酶组合物。 酶组合物选自第一酶，第二酶及其组合。 第一种酶用于消除电负性低密度脂蛋白（电负性LDL）的聚糖残基。 第二种酶用于消除由负电性低密度脂蛋白携带的神经酰胺。 生物化学反应性材料能够消除电负性低密度脂蛋白。

公开(公告)号：US20140220085A1

公开(公告)日：2014-08-07

申请号：US14251472

申请日：2014-04-11

Applicant: Industrial Technology Research Institute

Inventor： Pei-Yi TSAI ,  Yi-Hung WEN ,  Zhi-Jie HUANG ,  Pei-Shan LI ,  Hsin-Hsin SHEN ,  Yi-Hung LIN ,  Chih-Hung CHEN

IPC: A61L27/54 ,  A61L27/10 ,  C12N5/00 ,  A61L27/12

CPC classification number: A61L27/10 ,  A61L27/12 ,  A61L27/28 ,  A61L27/54 ,  A61L2300/624 ,  A61L2400/12 ,  C12N5/0068

Abstract: In an embodiment of the disclosure, a biomedical material is provided. The biomedical material includes a biocompatible material having a surface and a carrier distributed over the surface of the biocompatible material, wherein both of the biocompatible material and the carrier have no charges, one of them has charges or both of them have charges with different electricity. The biomedical material is utilized for dentistry, orthopedics, wound healing or medical beauty and applied in the repair and regeneration of various soft and hard tissues.

Abstract translation: 在本公开的一个实施方案中，提供生物医学材料。 生物医学材料包括具有分布在生物相容性材料的表面上的表面和载体的生物相容性材料，其中生物相容性材料和载体都不具有电荷，其中之一具有电荷，或者两者都具有不同电荷的电荷。 生物医学材料用于牙科，骨科，伤口愈合或医疗美容，并用于各种软组织和硬组织的修复和再生。