公开(公告)号：US20240016954A1

公开(公告)日：2024-01-18

申请号：US18471821

申请日：2023-09-21

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Wen-Chia HUANG ,  Yen-Jen WANG ,  Felice CHENG ,  Chia-Ching CHEN ,  Shao-Chan YIN ,  Chien Lin PAN ,  Tsan-Lin HU ,  Meng-Nan LIN ,  Kuo-Kuei HUANG ,  Maggie LU ,  Chih-Peng LIU

IPC: A61K47/69 ,  A61K47/22 ,  A61K9/00 ,  A61K9/08 ,  A61K47/10 ,  A61K47/32 ,  A61K47/40 ,  A61K47/38

CPC classification number: A61K47/6951 ,  A61K47/22 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0053 ,  A61K9/08 ,  A61K47/10 ,  A61K47/32 ,  A61K47/40 ,  A61K47/38 ,  A61K31/47

Abstract: A composition for improving the solubility of poorly soluble substances is provided. The composition for improving the solubility of poorly soluble substances includes 60-97% by weight of cyclodextrin and/or a derivative thereof, 0.5-4% by weight of at least one water-soluble polymer and 0.4-30% by weight of at least one water-soluble stabilizer, wherein the at least one water-soluble stabilizer includes caffeine, and wherein the poorly soluble substance is a tyrosine kinase inhibitor.

公开(公告)号：US20190209706A1

公开(公告)日：2019-07-11

申请号：US16232601

申请日：2018-12-26

Applicant: Industrial Technology Research Institute

Inventor： Wen-Chia HUANG ,  Yen-Jen WANG ,  Felice CHENG ,  Chia-Ching CHEN ,  Shao-Chan YIN ,  Chien-Lin PAN ,  Tsan-Lin HU ,  Meng-Nan LIN ,  Kuo-Kuei HUANG ,  Maggie LU ,  Chih-Peng LIU

IPC: A61K47/69 ,  A61K31/569 ,  A61K47/38 ,  A61K9/08

CPC classification number: A61K47/6951 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0053 ,  A61K9/08 ,  A61K31/4439 ,  A61K31/569 ,  A61K47/38 ,  A61K47/40 ,  A61K47/65

Abstract: A composition for improving the solubility of poorly soluble substances is provided. The composition includes about 40-99.5% by weight of cyclodextrin and/or derivatives thereof; about 0.05-10% by weight of at least one water-soluble polymer; and about 0.05-60% by weight of at least one water-soluble stabilizer.

公开(公告)号：US20220202610A1

公开(公告)日：2022-06-30

申请号：US17139360

申请日：2020-12-31

Applicant: Industrial Technology Research Institute

Inventor： Felice CHENG ,  Wen-Chia HUANG ,  Shao-Chan YIN ,  Po-Hsien KUO ,  Li-Wen CHANG ,  Yen-Jen WANG

IPC: A61F9/00 ,  G02B1/04 ,  C08B37/16 ,  C08G83/00 ,  C08F220/18 ,  C08F220/20 ,  C08F222/10

Abstract: A contact lens with sustained-release property is provided. The contact lens includes a polymer, pseudorotaxane embedded in the polymer, and a stabilizer embedded in the pseudorotaxane. The polymer is polymerized by monomer materials. The monomer materials include ethyl methacrylate, ethylene glycol dimethacrylate, methacrylic acid, 2-hydroxyethyl methacrylate, or a combination thereof. The stabilizer includes surfactant, amino acid with a polar side chain, oligopeptide containing at least one amino acid with a polar side chain, purine or its derivative, or a combination thereof.