公开(公告)号：US20140171443A1

公开(公告)日：2014-06-19

申请号：US13968089

申请日：2013-08-15

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Yen-Fang WEN ,  Yuan-Jang TSAI ,  Wan-Ru CHEN ,  Tsan-Lin HU ,  Chia-Mu TU ,  Chih-Peng LIU

IPC: C07D403/04

CPC classification number: C07D403/04

Abstract: The disclosure is directed to a monohydrate crystalline form of 3-(5-(4-(3-fluoropropyl)piperazin-1-yl)benzimidazol-2-yl)-1-azaazulen-2-one, possessing diffraction peaks of about 12.9°, 15.9°, 17.9°, 21.2°, 22.9°, 23.5° and 24.5°. Its preparation method and pharmaceutical composition thereof are also provided.

Abstract translation: 本发明涉及一水合物结晶形式的3-（5-（4-（3-氟丙基）哌嗪-1-基）苯并咪唑-2-基）-1-氮杂薁-2-酮，具有约12.9的衍射峰 °，15.9°，17.9°，21.2°，22.9°，23.5°和24.5°。 还提供了其制备方法和药物组合物。

公开(公告)号：US20190209706A1

公开(公告)日：2019-07-11

申请号：US16232601

申请日：2018-12-26

Applicant: Industrial Technology Research Institute

Inventor： Wen-Chia HUANG ,  Yen-Jen WANG ,  Felice CHENG ,  Chia-Ching CHEN ,  Shao-Chan YIN ,  Chien-Lin PAN ,  Tsan-Lin HU ,  Meng-Nan LIN ,  Kuo-Kuei HUANG ,  Maggie LU ,  Chih-Peng LIU

IPC: A61K47/69 ,  A61K31/569 ,  A61K47/38 ,  A61K9/08

CPC classification number: A61K47/6951 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0053 ,  A61K9/08 ,  A61K31/4439 ,  A61K31/569 ,  A61K47/38 ,  A61K47/40 ,  A61K47/65

Abstract: A composition for improving the solubility of poorly soluble substances is provided. The composition includes about 40-99.5% by weight of cyclodextrin and/or derivatives thereof; about 0.05-10% by weight of at least one water-soluble polymer; and about 0.05-60% by weight of at least one water-soluble stabilizer.

公开(公告)号：US20140199369A1

公开(公告)日：2014-07-17

申请号：US13926363

申请日：2013-06-25

Applicant: Industrial Technology Research Institute

Inventor： Maggie J.M. LU ,  Yu-Wen LO ,  Chih-Peng LIU ,  Chia-Wen HUANG ,  Po-Hung LAI ,  Tsan-Lin HU ,  Min-Ying LIN ,  Shuen-Hsiang CHOU ,  Chia-Mu TU

IPC: A61K47/36

CPC classification number: A61K47/36 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/127

Abstract: The disclosure provides a pharmaceutical composition. The pharmaceutical composition includes a chitosan with palmitoyl groups and an active agent. According to another embodiment, the pharmaceutical composition can further include a gelling accelerating agent. According to an embodiment of the disclosure, the active agent of the disclosure can be administered in the form of a nano-drug, liposome, micelle, or microparticle.

Abstract translation: 本公开提供药物组合物。 药物组合物包括具有棕榈酰基团的壳聚糖和活性剂。 根据另一个实施方案，药物组合物可以进一步包括胶凝加速剂。 根据本公开的实施方案，本公开的活性剂可以以纳米药物，脂质体，胶束或微粒的形式施用。

公开(公告)号：US20240016954A1

公开(公告)日：2024-01-18

申请号：US18471821

申请日：2023-09-21

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Wen-Chia HUANG ,  Yen-Jen WANG ,  Felice CHENG ,  Chia-Ching CHEN ,  Shao-Chan YIN ,  Chien Lin PAN ,  Tsan-Lin HU ,  Meng-Nan LIN ,  Kuo-Kuei HUANG ,  Maggie LU ,  Chih-Peng LIU

IPC: A61K47/69 ,  A61K47/22 ,  A61K9/00 ,  A61K9/08 ,  A61K47/10 ,  A61K47/32 ,  A61K47/40 ,  A61K47/38

CPC classification number: A61K47/6951 ,  A61K47/22 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0053 ,  A61K9/08 ,  A61K47/10 ,  A61K47/32 ,  A61K47/40 ,  A61K47/38 ,  A61K31/47

Abstract: A composition for improving the solubility of poorly soluble substances is provided. The composition for improving the solubility of poorly soluble substances includes 60-97% by weight of cyclodextrin and/or a derivative thereof, 0.5-4% by weight of at least one water-soluble polymer and 0.4-30% by weight of at least one water-soluble stabilizer, wherein the at least one water-soluble stabilizer includes caffeine, and wherein the poorly soluble substance is a tyrosine kinase inhibitor.

公开(公告)号：US20220227771A1

公开(公告)日：2022-07-21

申请号：US17561055

申请日：2021-12-23

Applicant: Industrial Technology Research Institute

Inventor： Chih-Wei FU ,  Hao-Hsuan LIU ,  Chiu-Lien HUNG ,  Yu-Chin LIN ,  Tsan-Lin HU ,  Chien-Chin HUANG

IPC: C07D487/04 ,  A61P35/00 ,  C07D417/14 ,  C07D417/12 ,  C07D401/04

Abstract: An androgen receptor (AR) binding molecule has the structure of Formula (I) shown in the following: wherein E and G independently are CH2 or CH, is OH, NH2, OTf or C≡C, X is CF3 or trifluorophenyl, and Y and Z independently are CH2 or CH; or is absent, X is CF3, and Y and Z independently are CH2.