公开(公告)号：US20140161842A1

公开(公告)日：2014-06-12

申请号：US13870178

申请日：2013-04-25

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Li-Hsin LIN ,  Hsin-Hsin SHEN ,  Ying-Hsueh CHAO ,  Hsiu-Hua HUANG ,  Yu-Bing LIOU ,  Chih-Bing HUNG ,  Chin-Fu CHEN

IPC: A61L27/26 ,  A61L27/58

CPC classification number: A61L27/26 ,  A61K9/006 ,  A61K9/70 ,  A61K9/7007 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  C08L67/04 ,  C08L71/02

Abstract: A bioresorbable porous film, including a blend mixture of polylactic acid and at least two kinds of polyethylene glycol, wherein the at least two kinds of polyethylene glycol include a first polyethylene glycol, which is in a solid form under ambient temperature and atmospheric pressure, and a second polyethylene glycol, which is in a liquid form under ambient temperature and atmospheric pressure is provided. The film has a porosity of 10%-90%.

Abstract translation: 一种生物可吸收多孔膜，其包括聚乳酸和至少两种聚乙二醇的混合物，其中所述至少两种聚乙二醇包括在环境温度和大气压下为固体形式的第一聚乙二醇，以及 提供在环境温度和大气压下为液体形式的第二聚乙二醇。 该膜的孔隙率为10％-90％。

公开(公告)号：US20210196648A1

公开(公告)日：2021-07-01

申请号：US16731979

申请日：2019-12-31

Applicant: Industrial Technology Research Institute

Inventor： Hsin-Hsin SHEN ,  Yuchi WANG ,  Li-Hsin LIN ,  Ming-Chia YANG ,  Hsiu-Hua HUANG ,  Liang-Cheng SU ,  Ying-Hsueh CHAO ,  Jing-En HUANG

IPC: A61K9/70

Abstract: A drug-containing multilayer film provided. The drug-containing multilayer film includes: a drug-containing layer; and an anti-adhesion layer on a surface of the drug-containing layer. The drug-containing layer is composed of a first composition including a first polymer material and a drug, and the first polymer material includes at least one selected from the group consisting of: polylactic acid (PLA) and polyethylene glycol (PEG), and the weight ratio of the first polymer material to the drug is about 1:0.01-0.3. The anti-adhesion layer is composed of a second composition, and the second composition includes a second polymer material, and the second polymer material includes at least one selected from the group consisting of polylactic acid and polyethylene glycol.

公开(公告)号：US20210269765A1

公开(公告)日：2021-09-02

申请号：US17126942

申请日：2020-12-18

Applicant: Industrial Technology Research Institute

Inventor： Chia-Jung LU ,  Jing-En HUANG ,  Liang-Cheng SU ,  Hsin-Hsin SHEN ,  Yuchi WANG ,  Ying-Hsueh CHAO ,  Li-Hsin LIN ,  Hsiu-Hua HUANG

IPC: C12N5/00 ,  A61K35/12 ,  A61K9/00 ,  A61K47/38 ,  A61K47/42

Abstract: A temperature-sensitive cell culture composition is provided. The temperature-sensitive cell culture composition includes a hydrogel, a cellulose, a gelatin and a collagen. Based on 1 part by weight of the collagen, a content of the hydrogel is between 0.03 parts by weight and 60 parts by weight, a content of the cellulose is between 150 parts by weight and 360 parts by weight, and a content of the gelatin is between 21 parts by weight and 12 parts by weight. In addition, a method for using the temperature-sensitive cell culture composition, a method for forming the temperature-sensitive cell culture composition, and a use of the temperature-sensitive cell culture composition are also provided.

公开(公告)号：US20140187591A1

公开(公告)日：2014-07-03

申请号：US13871491

申请日：2013-04-26

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Hsin-Hsin SHEN ,  Yu-Bing LIOU ,  Chin-Fu CHEN ,  Li-Hsin LIN ,  Hsiu-Hua HUANG ,  Ying-Hsueh CHAO ,  Meng-Yow HSIEH ,  Miao-Tzu CHEN ,  Chih-Bing HUNG

IPC: A61L27/54

CPC classification number: A61K47/34 ,  A61K9/0024

Abstract: The disclosure provides a solid form and a method for preparing the same. The solid form consists essentially of a biodegradable copolymer and an amide-containing compound. The biodegradable copolymer is semi-crystalline due to the dipole-dipole interaction between the biodegradable copolymer and the urea. The method for preparing the above solid form includes: dissolving a biodegradable copolymer and an amide-containing compound in water at a first temperature, obtaining a solution; cooling the solution at a second temperature to form a solid mixture; and the solid mixture is subjected to a freeze-drying process at a third temperature.

Abstract translation: 本公开提供了一种固体形式及其制备方法。 固体形式基本上由可生物降解的共聚物和含酰胺的化合物组成。 由于可生物降解的共聚物和尿素之间的偶极 - 偶极相互作用，生物降解性共聚物是半结晶的。 制备上述固体形式的方法包括：在第一温度下将可生物降解的共聚物和含酰胺的化合物溶解在水中，得到溶液; 在第二温度下冷却溶液以形成固体混合物; 并将固体混合物在第三温度下进行冷冻干燥处理。