DRUG-CONTAINING MULTILAYER FILM AND METHOD FOR FORMING THE SAME

    公开(公告)号:US20210196648A1

    公开(公告)日:2021-07-01

    申请号:US16731979

    申请日:2019-12-31

    Abstract: A drug-containing multilayer film provided. The drug-containing multilayer film includes: a drug-containing layer; and an anti-adhesion layer on a surface of the drug-containing layer. The drug-containing layer is composed of a first composition including a first polymer material and a drug, and the first polymer material includes at least one selected from the group consisting of: polylactic acid (PLA) and polyethylene glycol (PEG), and the weight ratio of the first polymer material to the drug is about 1:0.01-0.3. The anti-adhesion layer is composed of a second composition, and the second composition includes a second polymer material, and the second polymer material includes at least one selected from the group consisting of polylactic acid and polyethylene glycol.

    SOLID FORM AND METHOD FOR PREPARING THE SAME
    7.
    发明申请
    SOLID FORM AND METHOD FOR PREPARING THE SAME 有权
    固体形式及其制备方法

    公开(公告)号:US20140187591A1

    公开(公告)日:2014-07-03

    申请号:US13871491

    申请日:2013-04-26

    CPC classification number: A61K47/34 A61K9/0024

    Abstract: The disclosure provides a solid form and a method for preparing the same. The solid form consists essentially of a biodegradable copolymer and an amide-containing compound. The biodegradable copolymer is semi-crystalline due to the dipole-dipole interaction between the biodegradable copolymer and the urea. The method for preparing the above solid form includes: dissolving a biodegradable copolymer and an amide-containing compound in water at a first temperature, obtaining a solution; cooling the solution at a second temperature to form a solid mixture; and the solid mixture is subjected to a freeze-drying process at a third temperature.

    Abstract translation: 本公开提供了一种固体形式及其制备方法。 固体形式基本上由可生物降解的共聚物和含酰胺的化合物组成。 由于可生物降解的共聚物和尿素之间的偶极 - 偶极相互作用,生物降解性共聚物是半结晶的。 制备上述固体形式的方法包括:在第一温度下将可生物降解的共聚物和含酰胺的化合物溶解在水中,得到溶液; 在第二温度下冷却溶液以形成固体混合物; 并将固体混合物在第三温度下进行冷冻干燥处理。

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