公开(公告)号：US09908117B2

公开(公告)日：2018-03-06

申请号：US14861677

申请日：2015-09-22

申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIVERSITY

发明人： Hyo Il Jung ,  Kyung-A Hyun ,  Tae Yoon Lee

IPC分类号： B01L3/00 ,  G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N33/543 ,  G01N33/50 ,  G01N33/569 ,  B01F5/06 ,  B01F13/00

CPC分类号： B01L3/502761 ,  B01F5/0647 ,  B01F5/0655 ,  B01F13/0059 ,  B01L3/502707 ,  B01L3/5085 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/044 ,  B01L2300/0858 ,  B01L2300/0883 ,  B01L2400/0409 ,  B01L2400/043 ,  G01N33/5002 ,  G01N33/54326 ,  G01N33/5434 ,  G01N33/54346 ,  G01N33/56972 ,  G01N2333/70589

摘要： The present invention relates to a microfluidic separation device, a separation method using the same and a kit for separating circulating rare cells from blood using the same, and more particularly, to a microfluidic-based separation technology for fixing target particles of a sample, which have a specific affinity for magnetic nanoparticles, to a device by use of a magnetic material, and for isolating the sample from which the target particles have been removed. The present invention may be effectively applied to remove leukocytes from a blood sample in order to isolate circulating rare cells (CRCs), particularly circulating tumor cells (CTCs).