公开(公告)号：US20240150374A1

公开(公告)日：2024-05-09

申请号：US18507566

申请日：2023-11-13

Applicant: Insilico Medicine IP Limited

Inventor： Xin CHENG ,  Luoheng QIN ,  Feng REN

IPC: C07D498/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

CPC classification number: C07D498/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: Described herein are KAT6A inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with KAT6A.

公开(公告)号：US20240002406A1

公开(公告)日：2024-01-04

申请号：US18339362

申请日：2023-06-22

Applicant: Insilico Medicine IP Limited

Inventor： Xiao DING ,  Liena QIN ,  Feng REN ,  Jianyu XU

IPC: C07D519/00 ,  C07D471/04

CPC classification number: C07D519/00 ,  C07D471/04

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of inflammatory bowel disease.

公开(公告)号：US20230192667A1

公开(公告)日：2023-06-22

申请号：US18110517

申请日：2023-02-16

Applicant: Insilico Medicine IP Limited

Inventor： Xin CHENG ,  Yingtao LIU ,  Luoheng QIN ,  Feng REN ,  Jianping WU

IPC: C07D403/14 ,  C07D403/04 ,  C07D417/14 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  A61P35/00

CPC classification number: C07D403/14 ,  A61P35/00 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: The disclosure provides for compounds and methods for modulating or inhibiting glutaminyl-peptide cyclotransferase-like protein (QPCTL). In one aspect, described herein are compounds of Formulas (I), (Ia), (Ib), (Iaa), (Iab), (Iba), (Ibb), (II), (IIa), (IIb), (IIaa) (IIab), (IIba), and (IIbb), stereoisomer thereof, or salts or solvates thereof. Further provided herein are methods of treating a disease or a condition comprising administering a compound of Formula (I), (Ia), (Ib), (Iaa), (Iab), (Iba), (Ibb), (II), (IIa), (IIb), (IIaa) (IIab), (IIba), or (IIbb), a stereoisomer thereof, or a salt or solvate thereof.

公开(公告)号：US20240166608A1

公开(公告)日：2024-05-23

申请号：US18529689

申请日：2023-12-05

Applicant: Insilico Medicine IP Limited

Inventor： Xiao DING ,  Jinxin LIU ,  Feng REN ,  Jianfei WAN ,  Wei ZHU

IPC: C07D231/56 ,  A61P35/00 ,  C07D209/44 ,  C07D215/14 ,  C07D401/04 ,  C07D403/08 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D231/56 ,  A61P35/00 ,  C07D209/44 ,  C07D215/14 ,  C07D401/04 ,  C07D403/08 ,  C07D471/04 ,  C07D487/04

Abstract: The disclosure provides for compounds and methods for modulating or inhibiting TEAD. Further provided herein are pharmaceutical compositions comprising the TEAD inhibitors and methods of treatment using the TEAD inhibitors or the pharmaceutical compositions.

公开(公告)号：US20230192723A1

公开(公告)日：2023-06-22

申请号：US18110261

申请日：2023-02-15

Applicant: Insilico Medicine IP Limited

Inventor： Xiao DING ,  Liena QIN ,  Feng REN ,  Jianyu XU

IPC: C07D519/00 ,  C07D471/04

CPC classification number: C07D519/00 ,  C07D471/04

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of anemia.

公开(公告)号：US20230192688A1

公开(公告)日：2023-06-22

申请号：US18110259

申请日：2023-02-15

Applicant: Insilico Medicine IP Limited

Inventor： Xiao DING ,  Liena QIN ,  Feng REN ,  Jianyu XU

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of inflammatory bowel disease.

公开(公告)号：US20250034132A1

公开(公告)日：2025-01-30

申请号：US18704366

申请日：2022-10-28

Applicant: Insilico Medicine IP Limited

Inventor： Xiao DING ,  Liena QIN ,  Feng REN ,  Jianyu XU

IPC: C07D471/04 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5377

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of inflammatory bowel disease.

公开(公告)号：US20240132465A1

公开(公告)日：2024-04-25

申请号：US18509658

申请日：2023-11-15

Applicant: Insilico Medicine IP Limited

Inventor： Chiachun CHEN ,  Xiao DING ,  Xiaosong LIU ,  Feng REN ,  Hailong WANG

IPC: C07D401/04 ,  C07D239/95 ,  C07D403/04 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D401/04 ,  C07D239/95 ,  C07D403/04 ,  C07D471/04 ,  C07D487/04

Abstract: Described herein are MAT2A inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with MAT2A.

公开(公告)号：US20240109880A1

公开(公告)日：2024-04-04

申请号：US18486369

申请日：2023-10-13

Applicant: Insilico Medicine IP Limited

Inventor： Xin CHENG ,  Luoheng QIN ,  Feng REN

IPC: C07D413/14 ,  C07D498/04 ,  C07D413/06 ,  C07D413/12 ,  C07D417/14 ,  C07D417/12 ,  C07D417/06

CPC classification number: C07D413/14 ,  C07D498/04 ,  C07D413/06 ,  C07D413/12 ,  C07D417/14 ,  C07D417/12 ,  C07D417/06

Abstract: Described herein are KAT6A inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with KAT6A.

公开(公告)号：US20230192624A1

公开(公告)日：2023-06-22

申请号：US18107127

申请日：2023-02-08

Applicant: Insilico Medicine IP Limited

Inventor： Xiao DING ,  Jingjing PENG ,  Feng REN ,  Xiaoyu DING ,  Bogdan ZAGRIBELNYY ,  Yan A. IVANENKOV

IPC: C07D233/96 ,  A61P31/14

CPC classification number: C07D233/96 ,  A61P31/14

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for treating a SARS-CoV-2 infection.