公开(公告)号：US20180348168A1

公开(公告)日：2018-12-06

申请号：US15778703

申请日：2016-11-25

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITÉ CLAUDE BERNARD LYON 1 ,  CENTRE LÉON-BÉRARD

发明人： Stefan CATHELINE ,  Jean-Yves CHAPELON ,  Cyril LAFON

IPC分类号： G01N29/04 ,  G01S7/52 ,  G01S15/89 ,  A61B8/08 ,  A61B8/00 ,  A61N7/02

CPC分类号： G01N29/041 ,  A61B8/085 ,  A61B8/0858 ,  A61B8/4444 ,  A61B8/485 ,  A61B8/5223 ,  A61N7/02 ,  A61N2007/0052 ,  A61N2007/0095 ,  G01N2291/0231 ,  G01N2291/0427 ,  G01S7/52022 ,  G01S7/52042 ,  G01S15/8922 ,  G01S15/8927

摘要： This method for determining a mechanical property of a layered soft material, includes steps of a) generating an ultrasound wave (W1) focused towards a first point (P1) of the material, said wave, upon interacting with a layer of said material, generating in turn a Lamb (L1) wave propagating into said layer of the material, b) measuring, at a second point (P2) of the material belonging to said layer, a physical parameter of the generated Lamb wave, c) automatically determining the mechanical property of the layered soft material, based on the measured physical parameter. Step a) is performed by exciting a first ultrasonic transducer (401) with a first excitation signal (S401) during at most 50 ms, step b) is performed by exciting a second ultrasonic transducer (402) with a second excitation signal (S402) during at most 0.5 ms, to generate multiple excitation ultrasound waves (W2) focused towards said second point (P2) and, then, collecting multiple reflected waves (W2′) emitted in response, said first and second ultrasonic transducers each comprises an oscillator having a quality factor equal to or superior to 100, preferably equal or superior to 1000.

公开(公告)号：US20180036558A1

公开(公告)日：2018-02-08

申请号：US15789426

申请日：2017-10-20

申请人： Vermon S.A. ,  Institut National de la Sante et de la Recherche Medicale (INSERM), U1032 ,  Universite Pierre Et Marie Curie (Paris 6) ,  CarThera S.A.S.

发明人： Alexandre CARPENTIER ,  An NGUYEN-DINH ,  Jean-Yves CHAPELON ,  Rémi DUFAIT ,  Christophe NOTARD ,  Françoise CHAVRIER ,  Cyril LAFON ,  Michael CANNEY ,  William Apoutou N'DJIN

IPC分类号： A61N7/02 ,  A61N7/00

CPC分类号： A61N7/02 ,  A61N7/022 ,  A61N2007/0043 ,  A61N2007/0047 ,  A61N2007/0078 ,  A61N2007/025

摘要： An interstitial ultrasound thermal ablation applicator for conformal treatment of an inhomogeneous tumor lesion includes: a body having a longitudinal axis; and a plurality of array transducers mounted on the body, arranged side by side and having azimuth directions parallel to the longitudinal axis of the body, and having outer faces disposed in a polygonal arrangement; the plurality of array transducers having predetermined elevation dimensions defined for directing emitted ultrasonic energy to obtain a conformal volume treatment of the tumor lesions. An electronic driving method for driving an applicator having multiple independent transducer elements arranged in rows and columns includes: controlling focal parameters of each row and column of transducer elements; and controlling a contribution of each row and column of transducer elements in a manner to provide a conformal ablated volume.

公开(公告)号：US20160367143A1

公开(公告)日：2016-12-22

申请号：US14903876

申请日：2014-07-10

申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) ,  Universite Claude Bernard Lyon 1

发明人： Stefan CATHELINE ,  Jean-Yves CHAPELON ,  Rémi SOUCHON ,  Pol GRASLAND-MONGRAIN ,  Cyril LAFON

IPC分类号： A61B5/00 ,  G01R33/563 ,  A61B8/08 ,  A61B5/053 ,  A61B5/055

CPC分类号： A61B5/0051 ,  A61B5/05 ,  A61B5/0536 ,  A61B5/055 ,  A61B8/485 ,  G01R33/56358

摘要： This shear wave imaging method, for collecting information on a target region (R) of a soft solid (S), comprises at fi least the steps a) of generating at least one shear wave (SW) in the target region, and b) of detecting a propagation pattern of the shear wave in the target region. Step a) is realized by applying to particles of the target region (R) some Lorentz forces resulting from an electric field (E) and from a magnetic field (B). At least one of the electric field (E) and the magnetic field (B) is variable in time, with a central frequency (fo) between 1 Hz and 10 kHz. Alternatively, both the electric and magnetic fields (E, B) are variable in time, with a central difference frequency (Δfo) between 1 Hz and 10 kHz. The shear wave imaging installation comprises a first system (4, 7) for generating at least one shear wave (SW) in the target region (R) and a second system (10) for detecting a propagation pattern of the shear wave. The first system includes first means (4) to apply an electric field (E) through the target region (R) and second means (7) to apply a magnetic field (B) through the target region. The first and second means are configured to apply to particles of the target region some Lorentz forces resulting from the electric field (E) and the magnetic field (B), where at least one of these fields is a quantity variable in time, with a central frequency (fo) between 1 Hz and 10 kHz, or both fields are quantities variable in time, with a central difference frequency (Δfo) between 1 Hz and 10 kHz.

摘要翻译： 用于收集关于软固体（S）的目标区域（R）的信息的剪切波成像方法至少包括在目标区域中产生至少一个剪切波（SW）的步骤a），以及b） 检测目标区域中的剪切波的传播模式。 步骤a）通过向目标区域（R）的粒子施加一些由电场（E）和磁场（B）产生的洛伦兹力来实现。 电场（E）和磁场（B）中的至少一个在时间上是可变的，中心频率（fo）在1Hz和10kHz之间。 或者，电场和磁场（E，B）在时间上是可变的，中心差频率（Δfo）在1Hz和10kHz之间。 剪切波成像设备包括用于在目标区域（R）中产生至少一个剪切波（SW）的第一系统（4,7）和用于检测剪切波的传播模式的第二系统（10）。 第一系统包括通过目标区域（R）和第二装置（7）施加电场（E）的第一装置（4），以通过目标区域施加磁场（B）。 第一和第二装置被配置为向目标区域的颗粒施加由电场（E）和磁场（B）产生的一些洛伦兹力，其中这些场中的至少一个是时间上的变量，其中 1 Hz至10 kHz之间的中心频率（fo），或两个场均为时间可变的量，中心频率（Δfo）介于1 Hz和10 kHz之间。

公开(公告)号：US20180317884A1

公开(公告)日：2018-11-08

申请号：US15763717

申请日：2016-09-29

申请人： INSTITUTE NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITÉ CLAUDE BERNARD LYON 1 ,  CENTRE LÉON-BÉRARD

发明人： Jean-Yves CHAPELON ,  Jean-Louis MESTAS ,  Cyril LAFON ,  Bernard GREILLIER ,  René MILLERET

IPC分类号： A61B8/00 ,  A61B90/00 ,  A61N7/02

CPC分类号： A61B8/4483 ,  A61B90/36 ,  A61B90/37 ,  A61B2017/22008 ,  A61B2090/378 ,  A61N7/02 ,  A61N2007/0078

摘要： This device (2) for generating ultrasonic waves in a target region of a soft solid, includes at least two ultrasound sources (32), light sources (40) distributed around a central axis (X2) of the device (2), for enlightening a zone of the soft solid via subsurface scattering, and a video camera (50), for capturing images of the zone enlightened by the lighting means. The ultrasound source (32), the light sources (40) and the video camera (50) are mounted on a body of the device (20) and oriented toward a common target zone which includes a focal point of the ultrasound sources (32). A boresight of the video camera is aligned on the central axis (X2).