-
公开(公告)号：US20240173395A1
公开(公告)日：2024-05-30
申请号：US17775094
申请日：2020-11-09
Inventor： Fu GAO , Lianpan DAI , Jinghua YAN , Kun XU , Yuxuan HAN , Qihui WANG , Qingrui HUANG , Jinhe LI
CPC classification number: A61K39/12 , A61P31/14 , C07K14/005 , C12N7/00 , C12N15/86 , A61K2039/5254 , A61K2039/53 , C12N2710/10334 , C12N2710/10343 , C12N2770/24122 , C12N2770/24134
Abstract: Provided in the present disclosure are a Zika/dengue vaccine and its application thereof. The present disclosure introduces a mutation into the E-protein FL fusion region of the Zika virus or dengue virus. Antigens with said mutations are unable to bind to antibodies that causes ADE. After immunization with the vaccine of the present disclosure acquired from the said antigens, production of FL epitope-induced antibodies can be prevented, thereby reducing or eliminating the ADE effect.
-
公开(公告)号：US20220305113A1
公开(公告)日：2022-09-29
申请号：US17827256
申请日：2022-05-27
Inventor： Lianpan DAI , Jinghua YAN , Fu GAO , Yan LI , Tianyi ZHENG , Kun XU , Mei LIU , Yaling AN , Yi SHI
IPC: A61K39/215 , C07K14/005 , A61K39/39 , A61P31/14
Abstract: The embodiments of the present disclosure relate to antigens of β-coronaviruses, preparation methods and uses thereof. The amino acid sequence of the antigen of the β-coronavirus includes an amino acid sequence arranged in a (A-B)-(A-B) pattern or an amino acid sequence arranged in a (A-B)-C-(A-B) pattern or an amino acid sequence arranged in a (A-B)-(A-B′) pattern or an amino acid sequence arranged in a (A-B)-C-(A-B′) pattern. The antigen of the β-coronavirus has a single-chain dimer structure. A single-chain dirtier expressed according to examples of the present disclosure is stable in content and has excellent immunogenicity as an antigen of a β-coronavirus, and a vaccine prepared by using the single-chain dimer as an antigen of a β-coronavirus can elicit high-titer neutralizing antibodies in mice.
-
Search Results
2
records
(took 0.015 seconds)
