公开(公告)号：US20240173395A1

公开(公告)日：2024-05-30

申请号：US17775094

申请日：2020-11-09

Applicant: Institute of Microbiology, Chinese Academy of Sciences

Inventor： Fu GAO ,  Lianpan DAI ,  Jinghua YAN ,  Kun XU ,  Yuxuan HAN ,  Qihui WANG ,  Qingrui HUANG ,  Jinhe LI

IPC: A61K39/12 ,  A61K39/00 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86

CPC classification number: A61K39/12 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  A61K2039/5254 ,  A61K2039/53 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2770/24122 ,  C12N2770/24134

Abstract: Provided in the present disclosure are a Zika/dengue vaccine and its application thereof. The present disclosure introduces a mutation into the E-protein FL fusion region of the Zika virus or dengue virus. Antigens with said mutations are unable to bind to antibodies that causes ADE. After immunization with the vaccine of the present disclosure acquired from the said antigens, production of FL epitope-induced antibodies can be prevented, thereby reducing or eliminating the ADE effect.

公开(公告)号：US20240262894A1

公开(公告)日：2024-08-08

申请号：US18566962

申请日：2022-06-13

Applicant: INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES

Inventor： Fu GAO ,  Lianpan DAI ,  Jian SONG ,  Senyu XU ,  Qihui WANG

IPC: C07K16/10 ,  A61K39/00 ,  G01N33/569 ,  G01N33/577

CPC classification number: C07K16/1027 ,  G01N33/56983 ,  G01N33/577 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/135 ,  G01N2469/10

Abstract: Provided in the present disclosure is an antibody or an antigen-binding fragment thereof that binds to the respiratory syncytial virus F protein. Further provided in the present disclosure is the use of the antibody or the antigen-binding fragment thereof in the preparation of a drug for the treatment and/or prevention of RSV infections.

公开(公告)号：US20220305113A1

公开(公告)日：2022-09-29

申请号：US17827256

申请日：2022-05-27

Applicant: INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES

Inventor： Lianpan DAI ,  Jinghua YAN ,  Fu GAO ,  Yan LI ,  Tianyi ZHENG ,  Kun XU ,  Mei LIU ,  Yaling AN ,  Yi SHI

IPC: A61K39/215 ,  C07K14/005 ,  A61K39/39 ,  A61P31/14

Abstract: The embodiments of the present disclosure relate to antigens of β-coronaviruses, preparation methods and uses thereof. The amino acid sequence of the antigen of the β-coronavirus includes an amino acid sequence arranged in a (A-B)-(A-B) pattern or an amino acid sequence arranged in a (A-B)-C-(A-B) pattern or an amino acid sequence arranged in a (A-B)-(A-B′) pattern or an amino acid sequence arranged in a (A-B)-C-(A-B′) pattern. The antigen of the β-coronavirus has a single-chain dimer structure. A single-chain dirtier expressed according to examples of the present disclosure is stable in content and has excellent immunogenicity as an antigen of a β-coronavirus, and a vaccine prepared by using the single-chain dimer as an antigen of a β-coronavirus can elicit high-titer neutralizing antibodies in mice.