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公开(公告)号：US20200179608A1
公开(公告)日：2020-06-11
申请号：US16794689
申请日：2020-02-19
申请人： Insulet Corporation
发明人： Maureen MCCAFFREY , David NAZZARO , Ian MCLAUGHLIN , Simon KOZIN
摘要： Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed.
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公开(公告)号：US20230063696A1
公开(公告)日：2023-03-02
申请号：US18045739
申请日：2022-10-11
申请人： INSULET CORPORATION
发明人： David NAZZARO , Ian MCLAUGHLIN , Daniel ALLIS , Simon KOZIN , Maureen MCCAFFREY
摘要： Systems and methods for monitoring an operational state and/or a fill status of a drug container of a drug delivery device are provided. The drug container can hold a liquid drug. A plunger can be positioned within the drug container. A drive system can advance the plunger to expel the liquid drug from the container. A monitoring system can detect a movement and/or a position of the plunger and/or any component coupled to the plunger. The detection can enable determination of an amount of liquid drug that has been expelled and/or an amount of liquid drug remaining in the drug container. Dosing rates, flow rates, and dosage completion can also be determined.
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公开(公告)号：US20180256823A1
公开(公告)日：2018-09-13
申请号：US15980469
申请日：2018-05-15
申请人： Insulet Corporation
发明人： David NAZZARO , Ian MCLAUGHLIN , Simon KOZIN , Maureen MCCAFFREY , Jackie MAC , Alexander DOUDOUMOPOULOS , Bhavin PATEL
CPC分类号： A61M5/31593 , A61M5/14248 , A61M5/28 , A61M5/31531 , A61M5/32 , A61M5/42 , A61M37/00 , A61M2005/2474 , A61M2005/3142 , A61M2005/31518
摘要： A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.
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公开(公告)号：US20180200444A1
公开(公告)日：2018-07-19
申请号：US15875115
申请日：2018-01-19
申请人： Insulet Corporation
发明人： Maureen MCCAFFREY , David NAZZARO , Ian MCLAUGHLIN , Simon KOZIN
CPC分类号： A61M5/285 , A61J1/2089 , A61M5/142 , A61M5/2455 , A61M5/2466 , A61M5/31573 , A61M5/3293 , A61M5/34 , A61M2005/31516
摘要： Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed.
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公开(公告)号：US20210379293A1
公开(公告)日：2021-12-09
申请号：US17408523
申请日：2021-08-23
申请人： Insulet Corporation
发明人： David NAZZARO , Ian MCLAUGHLIN , Simon KOZIN , Maureen MCCAFFREY , Jackie MAC , Alexander DOUDOUMOPOULOS , Bhavin PATEL
摘要： A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.
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公开(公告)号：US20180126068A1
公开(公告)日：2018-05-10
申请号：US15809491
申请日：2017-11-10
申请人： Insulet Corporation
发明人： David NAZZARO , Simon KOZIN , Maureen MCCAFFREY
CPC分类号： A61M5/1452 , A61M5/14248 , A61M5/16804 , A61M5/16877 , A61M5/31536 , A61M5/31546 , A61M5/31568 , A61M2005/14533 , A61M2005/3154
摘要： Ratchet-based drive systems for more reliable and safer drug delivery are provided. The ratchet-based drive systems restrict angular movement and/or linear movement of components that cause a plunger to expel a liquid drug from a drug container. Movement of the components can be restricted to correspond to a predetermined or desired portion of the liquid drug. In the case that control of the drive system is lost or fails, the maximum amount of drug that could be delivered is limited to a known amount, thereby reducing the likelihood of an overdose.
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公开(公告)号：US20220331521A1
公开(公告)日：2022-10-20
申请号：US17855910
申请日：2022-07-01
申请人： Insulet Corporation
发明人： David NAZZARO , Ian MCLAUGHLIN , Maureen MCCAFFREY , Simon KOZIN , Jackie MAC
摘要： A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.
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公开(公告)号：US20200376191A1
公开(公告)日：2020-12-03
申请号：US16995527
申请日：2020-08-17
申请人： Insulet Corporation
发明人： David NAZZARO , Simon KOZIN , Maureen MCCAFFREY
摘要： Ratchet-based drive systems for more reliable and safer drug delivery are provided. The ratchet-based drive systems restrict angular movement and/or linear movement of components that cause a plunger to expel a liquid drug from a drug container. Movement of the components can be restricted to correspond to a predetermined or desired portion of the liquid drug. In the case that control of the drive system is lost or fails, the maximum amount of drug that could be delivered is limited to a known amount, thereby reducing the likelihood of an overdose.
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公开(公告)号：US20190091404A1
公开(公告)日：2019-03-28
申请号：US16140186
申请日：2018-09-24
申请人： Insulet Corporation
发明人： David NAZZARO , Ian MCLAUGHLIN , Maureen MCCAFFREY , Simon KOZIN , Jackie Mac
摘要： A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.
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公开(公告)号：US20180043105A1
公开(公告)日：2018-02-15
申请号：US15676604
申请日：2017-08-14
申请人： Insulet Corporation
发明人： David NAZZARO , Ian MCLAUGHLIN , Daniel ALLIS , Simon KOZIN , Maureen MCCAFFREY
摘要： Systems and methods for monitoring an operational state and/or a fill status of a drug container of a drug delivery device are provided. The drug container can hold a liquid drug. A plunger can be positioned within the drug container. A drive system can advance the plunger to expel the liquid drug from the container. A monitoring system can detect a movement and/or a position of the plunger and/or any component coupled to the plunger. The detection can enable determination of an amount of liquid drug that has been expelled and/or an amount of liquid drug remaining in the drug container. Dosing rates, flow rates, and dosage completion can also be determined.
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