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公开(公告)号：US10329611B2
公开(公告)日：2019-06-25
申请号：US15911801
申请日：2018-03-05
发明人： Steven Gordon , Jerzy Olejnik
IPC分类号： C12Q1/68 , C12Q1/6869 , C07H19/00 , G01N21/05 , G01N21/64 , C12Q1/6874 , G01N21/03
摘要： The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.
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公开(公告)号：US20180251832A1
公开(公告)日：2018-09-06
申请号：US15911801
申请日：2018-03-05
发明人： Steven Gordon , Jerzy Olejnik
IPC分类号： C12Q1/6869 , C12Q1/6874 , G01N21/05 , G01N21/64 , G01N21/03
CPC分类号： C07H19/00 , C12Q1/6869 , C12Q1/6874 , C12Q2535/101 , G01N21/05 , G01N21/6428 , G01N21/645 , G01N2021/0346 , G01N2021/058 , G01N2021/6417 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6471 , G01N2201/062 , G01N2201/0627 , G01N2201/12
摘要： The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.
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公开(公告)号：US10017816B2
公开(公告)日：2018-07-10
申请号：US15095560
申请日：2016-04-11
发明人： Steven Gordon , Jerzy Olejnik
IPC分类号： C12Q1/6874 , C12Q1/6869
CPC分类号： C12Q1/6874 , C12Q1/6869 , C12Q2525/117 , C12Q2565/30
摘要： The invention relates to methods and compositions, and systems for determining the identity of nucleic acids in nucleotide sequences, and in particular, sequences that contain consecutive repeats of a particular base. For example, a consecutive repeat of a particular base may be identified by a charged ion detection (e.g., hydrogen ion detection).
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公开(公告)号：US20140335528A1
公开(公告)日：2014-11-13
申请号：US14264758
申请日：2014-04-29
发明人： Jerzy Olejnik , Steven Gordon , Martina Werner
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6844 , C12Q2537/159 , C12Q2563/131 , C12Q2563/149 , C12Q2563/159
摘要： Methods and compositions for enriching a population of particles containing an analyte are disclosed. In one embodiment, enrichment beads are used that are larger in size than the beads used for amplification. A separation device is employed that can retain larger beads with bound amplified beads. The technique finds many uses, including enriching for beads with clonally amplified template, which can be used in a variety of assays, including nucleic acid sequencing.
摘要翻译： 公开了用于富集含有分析物的颗粒群的方法和组合物。 在一个实施方案中，使用比用于扩增的珠更大的富集珠。 使用分离装置，其可以用结合的扩增珠粒保留较大的珠粒。 该技术发现许多用途，包括用克隆扩增模板富集珠，可用于多种测定，包括核酸测序。
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公开(公告)号：US20170029884A1
公开(公告)日：2017-02-02
申请号：US15214737
申请日：2016-07-20
发明人： Steven Gordon , Jerzy Olejnik
CPC分类号： C07H19/00 , C12Q1/6869 , C12Q1/6874 , C12Q2535/101 , G01N21/05 , G01N21/6428 , G01N21/645 , G01N2021/0346 , G01N2021/058 , G01N2021/6417 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6471 , G01N2201/062 , G01N2201/0627 , G01N2201/12
摘要： The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.
摘要翻译： 本发明提供了方法和组合物，包括但不限于使用例如通过合成方法的测序获得的数据来确定核苷酸序列中核酸的身份的算法，计算机可读介质，计算机程序，装置和系统。 本发明的方法包括校正核苷酸测序期间遇到的一种或多种现象，例如通过合成方法进行测序。 这些现象包括但不限于序列引导，序列滞后，光谱串扰以及由照明和/或滤波器响应变化引起的噪声。
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公开(公告)号：US10174066B2
公开(公告)日：2019-01-08
申请号：US15480043
申请日：2017-04-05
发明人： Steven Gordon , Jerzy Olejnik
IPC分类号： C07H19/00 , G01N21/05 , G01N21/64 , C12Q1/6869 , C12Q1/6874 , G01N21/03
摘要： The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.
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公开(公告)号：US10160995B2
公开(公告)日：2018-12-25
申请号：US14264758
申请日：2014-04-29
发明人： Jerzy Olejnik , Steven Gordon , Martina Werner
IPC分类号： C12Q1/68 , C12Q1/6806 , C12Q1/6844
摘要： Methods and compositions for enriching a population of particles containing an analyte are disclosed. In one embodiment, enrichment beads are used that are larger in size than the beads used for amplification. A separation device is employed that can retain larger beads with bound amplified beads. The technique finds many uses, including enriching for beads with clonally amplified template, which can be used in a variety of assays, including nucleic acid sequencing.
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公开(公告)号：US09909174B2
公开(公告)日：2018-03-06
申请号：US15214737
申请日：2016-07-20
发明人： Steven Gordon , Jerzy Olejnik
CPC分类号： C07H19/00 , C12Q1/6869 , C12Q1/6874 , C12Q2535/101 , G01N21/05 , G01N21/6428 , G01N21/645 , G01N2021/0346 , G01N2021/058 , G01N2021/6417 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6471 , G01N2201/062 , G01N2201/0627 , G01N2201/12
摘要： The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.
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公开(公告)号：US09605301B2
公开(公告)日：2017-03-28
申请号：US14456321
申请日：2014-08-11
CPC分类号： C12Q1/6869 , C12Q1/6806 , C12Q1/6825 , G06F19/20 , C12Q2527/137 , C12Q2525/186 , C12Q2525/117 , C12Q2565/601 , C12Q2563/107 , C12Q2537/165
摘要： The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.
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公开(公告)号：US20170022555A1
公开(公告)日：2017-01-26
申请号：US15215234
申请日：2016-07-20
发明人： Jerzy Olejnik , Dirk Zimmerman
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2563/107 , C12Q2565/629
摘要： Modular flow cells, devices with modular flow cells, and methods of sequencing using modular flow cells, as well as systems and kits including modular flow cells, are described, permitting sequencing wherein less than the full capacity for sequencing is desired.
摘要翻译： 描述了模块化流动池，具有模块化流动池的装置以及使用模块化流动池的排序方法，以及包括模块化流动池的系统和试剂盒，其允许测序，其中需要小于全部测序能力。
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