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公开(公告)号：US12194465B2
公开(公告)日：2025-01-14
申请号：US18062082
申请日：2022-12-06
Applicant: International Business Machines Corporation
Inventor： Benjamin Wunsch , Joshua T. Smith , Stacey Gifford , Sung-Cheol Kim
IPC: B01L3/00
Abstract: Techniques regarding one or more structures that can facilitate automated, multi-stage processing of one or more nanofluidic chips are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a roller positioned adjacent to a microfluidic card comprising a plurality of fluid reservoirs in fluid communication with a plurality of nanofluidic chips. An arrangement of the plurality of nanofluidic chips on the microfluidic card can defines a processing sequence driven by a translocation of the roller across the microfluidic card.
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公开(公告)号：US11911762B2
公开(公告)日：2024-02-27
申请号：US17314496
申请日：2021-05-07
Applicant: International Business Machines Corporation
Inventor： Joshua T. Smith , Benjamin Wunsch , Stacey Gifford , Sung-Cheol Kim
CPC classification number: B01L3/502753 , G06T7/0012 , B01L2300/0654
Abstract: Techniques regarding integrated purification-detection devices for detecting one or more biomarkers are provided. For example, one or more embodiments described herein are directed to an apparatus, comprising a housing and a microfluidic chip contained within the housing. The microfluidic chip comprises a separation unit that separates, using one or more nano deterministic lateral displacement (nanoDLD) arrays, target biological entities having a defined size range from other biological entities included in a biological fluid sample. The microfluidic chip further comprises a detection unit that facilitates detecting presence of one or more biomarkers associated with the target biological entities using one or more detection molecules or macromolecules that chemically reacts with the one or more biomarkers.
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公开(公告)号：US11872560B2
公开(公告)日：2024-01-16
申请号：US17132849
申请日：2020-12-23
Applicant: International Business Machines Corporation
Inventor： Joshua T. Smith , Stacey M. Gifford , Sung-Cheol Kim , Benjamin H. Wunsch
CPC classification number: B01L3/502753 , G01N1/4077 , B01L2200/0647 , B01L2200/0652 , B01L2300/0809 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/1894 , G01N1/34
Abstract: Microfluid chips that comprise one or more microscale and/or mesoscale condenser arrays, which can facilitate particle purification and/or fractionation, are described herein. In one embodiment, an apparatus can comprise a layer of a microfluidic chip. The layer can comprise an inlet that can receive fluid, an outlet that can output a purified version of the fluid, and a condenser array coupled between and in fluid communication with the inlet and the outlet. The condenser array can comprise a plurality of pillars arranged in a plurality of columns. Also, a pillar gap sized to facilitate a throughput rate of the fluid of greater than or equal to about 1.0 nanoliter per hour can be located between a first pillar of the plurality of pillars in a first column of the plurality of columns and a second pillar of the plurality of pillars in the first column.
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公开(公告)号：US20220143605A1
公开(公告)日：2022-05-12
申请号：US17095538
申请日：2020-11-11
Applicant: International Business Machines Corporation
Inventor： Joshua T. Smith , Benjamin Hardy Wunsch , Adele L. Pacquette , Eugene J. O'Sullivan
IPC: B01L3/00
Abstract: A method of forming a microfluidic device is disclosed. The method includes forming a first dielectric layer on a substrate, forming electrodes partially into the first dielectric layer, and forming a second dielectric layer on the electrodes. The method includes filling, with a metal material, two wells formed in the second dielectric layer such that the metal material is in direct contact with the electrodes. The method includes forming a third dielectric layer on the metal material and second dielectric layer. The method includes filling, with a structural material, a channel formed between the wells such that the structural material does not directly contact the electrodes. The method includes forming a fourth dielectric layer on the third dielectric layer and the structural material, extracting the structural material through at least one vent hole in the fourth dielectric layer, and forming a fifth dielectric layer on the fourth dielectric layer.
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5.发明授权公开(公告)号：US11192101B2
公开(公告)日：2021-12-07
申请号：US16419684
申请日：2019-05-22
Applicant: International Business Machines Corporation
Inventor： Chi-Chun Liu , Yann Mignot , Joshua T. Smith , Bassem M. Hamieh , Nelson Felix , Robert L. Bruce
Abstract: A microfluidic chip with high volumetric flow rate is provided that includes at least two vertically stacked microfluidic channel layers, each microfluidic channel layer including an array of spaced apart pillars. Each microfluidic channel layer is interconnected by an inlet/outlet opening that extends through the microfluidic chip. The microfluidic chip is created without wafer to wafer bonding thus circumventing the cost and yield issues associated with microfluidic chips that are created by wafer bonding.
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Patent Agency Ranking
公开(公告)号：US11186480B2
公开(公告)日：2021-11-30
申请号：US16276342
申请日：2019-02-14
Applicant: International Business Machines Corporation
Inventor： Joshua T. Smith , Stacey Gifford , Sung-Cheol Kim , Benjamin Wunsch
Abstract: An exemplary method includes forming a sacrificial layer along sidewalls of an array of trenches that are indented into a substrate, depositing a fill layer over the sacrificial layer, and then creating an array of gaps between the fill layer and the substrate by removing the sacrificial layer along the sidewalls of the trenches, while maintaining a structural connection between the substrate and the fill layer at the floors of the trenches. The method further includes covering the substrate, the fill layer, and the gaps with a cap layer that seal fluid-tight against the substrate and the fill layer. The method further includes indenting a first reservoir and a second reservoir through the cap layer, and into the substrate and the fill layer, across the lengths of the array of gaps, so that the array of gaps connects the first reservoir in fluid communication with the second reservoir.
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公开(公告)号：US20210231543A1
公开(公告)日：2021-07-29
申请号：US17227522
申请日：2021-04-12
Applicant: International Business Machines Corporation
Inventor： Benjamin H. Wunsch , Joshua T. Smith , Sung-Cheol Kim , Stacey M. Gifford
Abstract: Microscale and/or mesoscale condenser arrays that can facilitate microfluidic separation and/or purification of mesoscale and/or nanoscale particles and methods of operation are described herein. An apparatus comprises a condenser array comprising pillars arranged in a plurality of columns, wherein a pillar gap greater than or equal to about 0.5 micrometers is located between a first pillar of the pillars in a first column of the columns and a second pillar of the plurality of pillars in the first column, and wherein the first pillar is adjacent to the second pillar. The first ratio can be characterized by Dx/Dy is less than or equal to a first defined value, wherein Dx represents a first distance across the lattice in a first direction, wherein Dy represents a second distance across the lattice in a second direction, and wherein the first direction is orthogonal to the second direction.
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8.发明申请公开(公告)号：US20210121844A1
公开(公告)日：2021-04-29
申请号：US16667898
申请日：2019-10-29
Applicant: International Business Machines Corporation
Inventor： Benjamin H. Wunsch , Stacey M. Gifford , Sung-Cheol Kim , Joshua T. Smith
Abstract: Methods of liquid-phase synthesis of polymers using polymer substrates and systems for facilitating such methods allow gating of a synthetic reaction into a binary (reacted or unreacted) readout. Polymer substrates are used as carriers for molecular reagents and act as separation tags that allow them to be purified using nanoscale deterministic lateral displacement. Two polymer substrates are linked together by a bond-forming reaction to form a longer polymer that includes a synthetic product. The synthetic product can be purified away from unreacted polymers/reagents using strand-length dependent lateral displacement.
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公开(公告)号：US20200166468A1
公开(公告)日：2020-05-28
申请号：US16203195
申请日：2018-11-28
Applicant: International Business Machines Corporation
Inventor： Benjamin Wunsch , Sung-Cheol Kim , Stacey Gifford , Joshua T. Smith
Abstract: Techniques regarding one or more structures for checking the via formation are provided. For example, one or more embodiments described herein can comprise an apparatus, which can comprise a microfluidic channel positioned on a silicon substrate. The apparatus can also comprise a pattern of material comprised within the microfluidic channel and positioned on a surface of the silicon substrate. Further, the pattern of material can define a future location of a through-silicon via. An advantage of such an apparatus can be that the pattern of material can facilitate checking whether the through-silicon via is fully or partially formed.
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10.发明申请公开(公告)号：US20200070151A1
公开(公告)日：2020-03-05
申请号：US16419707
申请日：2019-05-22
Applicant: International Business Machines Corporation
Inventor： Chi-Chun Liu , Yann Mignot , Joshua T. Smith , Bassem M. Hamieh , Nelson Felix , Robert L. Bruce
Abstract: A microfluidic chip with a high volumetric flow rate is provided that includes at least two vertically stacked microfluidic channel layers, each microfluidic channel layer including an array of spaced apart pillars. Each microfluidic channel layer is interconnected by an inlet/outlet opening that extends through the microfluidic chip. The microfluidic chip is created without wafer to wafer bonding thus circumventing the cost and yield issues associated with microfluidic chips that are created by wafer bonding.
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