-
公开(公告)号：US11549943B2
公开(公告)日：2023-01-10
申请号：US16428961
申请日：2019-05-31
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Jaione Tirapu Azpiroz , Ademir Ferreira da Silva , Matheus Esteves Ferreira , Ricardo Luis Ohta , Mathias B. Steiner , Nara Mazarakis Rubim , Pedro Paulo Ferreira Ribeiro , Edimilson Domingos da Silva , Antonio Gomez Pinto Ferreira
IPC: G01N33/543 , G01N33/53 , G01N33/536
Abstract: A multiplexed lateral flow assay device includes an impermeable internal reservoir having an opening to receive a sample deposition. A fluid distributor pad is arranged in fluid communication with a lower surface of the internal reservoir and divides a portion of the sample deposition substantially equally among a plurality of flow paths. Lateral flow assays having a plurality of flow lines are aligned with flow paths of the distributor pad. An impermeable paper top cover has a first window arranged over the opening of the internal reservoir, and at least a second window arranged over the test results of the lateral flow assays. A housing element houses the reservoir, the distributor pad and lateral flow assays. The housing element includes an impermeable bottom cover and a spacer element arranged between the top and bottom covers and, provides a gap between the lateral flow assays and the impermeable paper top cover.
-
公开(公告)号：US20220100731A1
公开(公告)日：2022-03-31
申请号：US17039719
申请日：2020-09-30
Applicant: International Business Machines Corporation
Inventor： JAIONE TIRAPU AZPIROZ , Ademir Ferreira da Silva , Percival Silva de Lucena , Matheus Esteves Ferreira , Ricardo Luis Ohta , Mathias B. Steiner
Abstract: A validation method applied to sensor data prior to submitting to a blockchain, a computer program product, and a system for validating chemical data. One embodiment may comprise receiving a sensor captured result at an application, applying the sensor captured result to a domain-specific statistical model of expected range of variability of measured results to extract a distribution of expected sensor values, computing a confidence value in the sensor captured result using the domain-specific statistical model, validating the confidence value against a required threshold of confidence, and submitting the sensor captured result for appending to the blockchain if the confidence level is validated against the threshold of confidence.
-
公开(公告)号：US11060968B2
公开(公告)日：2021-07-13
申请号：US15941692
申请日：2018-03-30
Applicant: International Business Machines Corporation
Inventor： Ricardo Luis Ohta , Ademir Ferreira da Silva , Andre de Oliveira Botelho , Matheus Esteves Ferreira , Jaione Tirapu Azpiroz , Michael Engel , Mathias Steiner
Abstract: A target sample to be chemically analyzed is received at a microfluidic device which is part of an analysis card. The microfluidic device includes at least one input layer configured to receive the target sample, at least one intermediary layer, and at least one readout layer configured to present one or more color attributes at one or more readout regions in response to one or more colorimetric reactions to the target sample. An image of the readout layer of the microfluidic device is obtained. A calibration file that corresponds to the analysis card is obtained. The calibration file includes a calibrated model of at least one color attribute based on data from at least one known chemical attribute of at least one standard sample processed by a calibration card. A data processing function is executed on the obtained image by comparing the one or more color attributes at the one or more readout regions to the calibrated model of the at least one color attribute to determine at least one chemical attribute of the target sample.
-
公开(公告)号：US20190302008A1
公开(公告)日：2019-10-03
申请号：US15941692
申请日：2018-03-30
Applicant: International Business Machines Corporation
Inventor： Ricardo Luis Ohta , Ademir Ferreira da Silva , Andre de Oliveira Botelho , Matheus Esteves Ferreira , Jaione Tirapu Azpiroz , Michael Engel , Mathias Steiner
Abstract: A target sample to be chemically analyzed is received at a microfluidic device which is part of an analysis card. The microfluidic device includes at least one input layer configured to receive the target sample, at least one intermediary layer, and at least one readout layer configured to present one or more color attributes at one or more readout regions in response to one or more colorimetric reactions to the target sample. An image of the readout layer of the microfluidic device is obtained. A calibration file that corresponds to the analysis card is obtained. The calibration file includes a calibrated model of at least one color attribute based on data from at least one known chemical attribute of at least one standard sample processed by a calibration card. A data processing function is executed on the obtained image by comparing the one or more color attributes at the one or more readout regions to the calibrated model of the at least one color attribute to determine at least one chemical attribute of the target sample.
-
公开(公告)号：US11534752B2
公开(公告)日：2022-12-27
申请号：US17138419
申请日：2020-12-30
Applicant: International Business Machines Corporation
Inventor： Ademir Ferreira da Silva , Jaione Tirapu Azpiroz , Matheus Esteves Ferreira , Mathias B Steiner , Daniel Vitor Lopes Marcondes Marçal
IPC: B01L3/00 , G01N21/78 , G01N33/543 , G01N21/77
Abstract: An embodiment includes a sample receiving region, a first diagnostic element that includes one or more colorimetric analysis regions, and a second diagnostic element that includes one or more lateral flow assay analysis regions. The embodiment also includes a first flow path that allows a portion of a liquid deposited at the sample receiving region to flow to the first diagnostic element. The embodiment also includes a second flow path that allows a portion of the liquid deposited at the sample receiving region to flow to the second diagnostic element.
-
Patent Agency Ranking
公开(公告)号：US11498069B2
公开(公告)日：2022-11-15
申请号：US17008611
申请日：2020-08-31
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Ademir Ferreira da Silva , Daniel Vitor Lopes Marcondes Marçal , Jaione Tirapu Azpiroz , Matheus Esteves Ferreira , Mathias B. Steiner , Ricardo Luis Ohta
Abstract: A rapid test device includes a micropad chip configured for a multi-parameter chemical testing of an input sample. A plurality of paper layers of the micropad chip are in fluid communication, including a sample absorption element, a filtering element configured to filter the input sample, and a sample distribution element configured to distribute the input sample received from the filtering element to a remainder of the plurality of paper layers. One or more reacting elements associated with the multi-parameter chemical testing of the input sample have one or more colorimetric reagents in fluid communication with the sample distribution element. A colorimetric result displaying element in fluid communication with the one or more reacting elements is configured to display a colorimetric result of the testing of the input sample with the at least one reacting element for a respective chemical test of the multi-parameter chemical testing.
-
公开(公告)号：US20220203358A1
公开(公告)日：2022-06-30
申请号：US17138024
申请日：2020-12-30
Applicant: International Business Machines Corporation
Inventor： Ricardo Luis Ohta , Jaione Tirapu Azpiroz , Matheus Esteves Ferreira , Daniel Vitor Lopes Marcondes Marçal , Ademir Ferreira da Silva , Mathias B. Steiner
Abstract: Devices and methods for controlling collection of liquid sample are described. In an example, a microfluidic device can include an analytical device and an actuator. The actuator can be connected to the analytical device. The actuator can be operable to absorb fluid. The actuator can guide the absorbed fluid to an input layer of the analytical device. The actuator can deform in response to an occurrence of an absorption condition. A degree of deformation of the actuator indicates a volume of fluid collected by the analytical device.
-
公开(公告)号：US20220062897A1
公开(公告)日：2022-03-03
申请号：US17008611
申请日：2020-08-31
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Ademir Ferreira da Silva , Daniel Vitor Lopes Marcondes Marçal , Jaione Tirapu Azpiroz , Matheus Esteves Ferreira , Mathias B. Steiner , Ricardo Luis Ohta
Abstract: A rapid test device includes a micropad chip configured for a multi-parameter chemical testing of an input sample. A plurality of paper layers of the micropad chip are in fluid communication, including a sample absorption element, a filtering element configured to filter the input sample, and a sample distribution element configured to distribute the input sample received from the filtering element to a remainder of the plurality of paper layers. One or more reacting elements associated with the multi-parameter chemical testing of the input sample have one or more colorimetric reagents in fluid communication with the sample distribution element. A colorimetric result displaying element in fluid communication with the one or more reacting elements is configured to display a colorimetric result of the testing of the input sample with the at least one reacting element for a respective chemical test of the multi-parameter chemical testing.
-
公开(公告)号：US20200378957A1
公开(公告)日：2020-12-03
申请号：US16428961
申请日：2019-05-31
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Jaione Tirapu Azpiroz , Ademir Ferreira da Silva , Matheus Esteves Ferreira , Ricardo Luis Ohta , Mathias B. Steiner , Nara Mazarakis Rubim , Pedro Paulo Ferreira Ribeiro , Edimilson Domingos da Silva , Antonio Gomez Pinto Ferreira
IPC: G01N33/536 , G01N33/53
Abstract: A multiplexed lateral flow assay device includes an impermeable internal reservoir having an opening to receive a sample deposition. A fluid distributor pad is arranged in fluid communication with a lower surface of the internal reservoir and divides a portion of the sample deposition substantially equally among a plurality of flow paths. Lateral flow assays having a plurality of flow lines are aligned with flow paths of the distributor pad. An impermeable paper top cover has a first window arranged over the opening of the internal reservoir, and at least a second window arranged over the test results of the lateral flow assays. A housing element houses the reservoir, the distributor pad and lateral flow assays. The housing element includes an impermeable bottom cover and a spacer element arranged between the top and bottom covers and, provides a gap between the lateral flow assays and the impermeable paper top cover.
-
公开(公告)号：US11906515B2
公开(公告)日：2024-02-20
申请号：US16845035
申请日：2020-04-09
Inventor： Jaione Tirapu Azpiroz , Ademir Ferreira da Silva , Matheus Esteves Ferreira , Ricardo Luis Ohta , Mathias B. Steiner , Antonio Gomes Pinto Ferreira , Edimilson Domingos da Silva , Nara Mazarakis Rubim , Pedro Paulo Ferreira Ribeiro
IPC: G01N33/543 , B01L3/00 , G01N33/571
CPC classification number: G01N33/54389 , B01L3/50273 , B01L3/502715 , G01N33/571 , B01L2200/10 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487
Abstract: A multiplexed lateral flow device includes an impermeable internal reservoir having an opening to receive a sample deposition. A fluid distributor pad is arranged in fluid communication with a lower surface of the internal reservoir. The fluid distributor pad includes a paper based microfluidic element having a pattern of a hydrophobic material to distribute a portion of the sample deposition substantially equally among a plurality of flow paths. Lateral flow assays having a plurality of flow lines are aligned with flow paths of the distributor pad. An impermeable top cover has a first window arranged over the opening of the internal reservoir, and at least a second window arranged over the test results of the lateral flow assays. A housing element houses the reservoir, the distributor pad and lateral flow assays. The housing element includes an impermeable bottom cover and a spacer element arranged between the top and bottom covers and, provides a gap between the lateral flow assays and the impermeable top cover.
-
-
-
-
-
-
-
-
-
Search Results
22
records
(took 0.021 seconds)
