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公开(公告)号:US08993807B2
公开(公告)日:2015-03-31
申请号:US13291932
申请日:2011-11-08
申请人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
发明人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
IPC分类号: C09B11/02 , C07C211/00 , A01N33/02 , A61K31/135 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C317/28 , C07C323/25 , C07D277/24 , C07D309/06
CPC分类号: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号:US08829244B2
公开(公告)日:2014-09-09
申请号:US13620388
申请日:2012-09-14
申请人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
发明人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
IPC分类号: C09B11/02 , C07C211/00 , C07D277/24 , C07C225/16 , C07C323/25 , C07C217/72 , C07C251/86 , C07D309/06 , C07C279/08 , C07C317/28 , C07C233/18 , C07C235/08 , C07C217/62 , C07C229/38 , C07C217/64 , C07C215/20 , C07C217/20 , C07C217/60
CPC分类号: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
摘要翻译: 本发明一般涉及用于治疗神经变性疾病和病症,特别是眼科疾病和病症的组合物和方法。 本文提供的是烷氧基衍生物化合物和包含这些化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症,包括年龄相关性黄斑变性(AMD)和斯塔尔加氏病。
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公开(公告)号:US09079825B2
公开(公告)日:2015-07-14
申请号:US13291948
申请日:2011-11-08
申请人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
发明人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
IPC分类号: C09B11/02 , C07C211/00 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C317/28 , C07C323/25 , C07D277/24 , C07D309/06
CPC分类号: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号:US20130197096A1
公开(公告)日:2013-08-01
申请号:US13620388
申请日:2012-09-14
申请人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
发明人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
IPC分类号: C07C215/20
CPC分类号: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号:US20120129894A1
公开(公告)日:2012-05-24
申请号:US13111679
申请日:2011-05-19
申请人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
发明人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
IPC分类号: A61K31/426 , A61K31/24 , A61K31/22 , A61K31/16 , A61K31/155 , A61K31/15 , A61K31/135 , C07D277/28 , C07D309/06 , C07C229/38 , C07C69/017 , C07C233/19 , C07C233/22 , C07C279/08 , C07C257/14 , C07C243/42 , C07C225/18 , C07C215/46 , A61K31/351
CPC分类号: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号:US20090326074A1
公开(公告)日:2009-12-31
申请号:US12287039
申请日:2008-10-03
申请人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
发明人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
IPC分类号: A61K31/135 , C07C211/03 , C07C215/28 , A61P27/02
CPC分类号: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
摘要翻译: 本发明一般涉及用于治疗神经变性疾病和病症,特别是眼科疾病和病症的组合物和方法。 本文提供的是烷氧基衍生物化合物和包含这些化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症,包括年龄相关性黄斑变性(AMD)和斯塔尔加氏病。
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公开(公告)号:US08981153B2
公开(公告)日:2015-03-17
申请号:US13111679
申请日:2011-05-19
申请人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
发明人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
IPC分类号: C07C211/00 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C317/28 , C07C323/25 , C07D277/24 , C07C309/06
CPC分类号: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号:US07982071B2
公开(公告)日:2011-07-19
申请号:US12287039
申请日:2008-10-03
申请人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
发明人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
IPC分类号: C09B11/02 , C07C211/00 , A01N43/40 , A61K31/44
CPC分类号: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
摘要翻译: 本发明一般涉及用于治疗神经变性疾病和病症,特别是眼科疾病和病症的组合物和方法。 本文提供的是烷氧基衍生物化合物和包含这些化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症,包括年龄相关性黄斑变性(AMD)和斯塔尔加氏病。
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公开(公告)号:US20120214852A1
公开(公告)日:2012-08-23
申请号:US13291948
申请日:2011-11-08
申请人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
发明人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
IPC分类号: A61K31/426 , A61K31/137 , C07C217/72 , C07C225/18 , C07C217/54 , A61K31/138 , C07C233/18 , A61K31/165 , C07C237/20 , C07C235/08 , C07D309/06 , A61K31/351 , C07D277/28 , A61P27/02 , C07C217/62
CPC分类号: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
摘要翻译: 本发明一般涉及用于治疗神经变性疾病和病症,特别是眼科疾病和病症的组合物和方法。 本文提供的是烷氧基衍生物化合物和包含这些化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症,包括年龄相关性黄斑变性(AMD)和斯塔尔加氏病。
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公开(公告)号:US20120122938A1
公开(公告)日:2012-05-17
申请号:US13291932
申请日:2011-11-08
申请人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
发明人: Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
IPC分类号: A61K31/426 , A61K31/24 , A61K31/22 , A61P27/02 , A61K31/165 , A61K31/155 , A61K31/135 , A61K31/351 , A61K31/16
CPC分类号: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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