公开(公告)号：US20080251712A1

公开(公告)日：2008-10-16

申请号：US12052267

申请日：2008-03-20

申请人： Ian Sanders ,  Gokhan Baykut ,  Jochen Franzen

发明人： Ian Sanders ,  Gokhan Baykut ,  Jochen Franzen

IPC分类号： B01D59/44

CPC分类号： H01J49/004 ,  G01N27/622

摘要： The mobility of mass-selected ions in gases is measured at pressures of a few hectopascal by selecting the ions under investigation in a quadrupole filter according to their mass-to-charge ratio m/z, measuring their mobility in a drift region at a pressure of a few hundred Pascal under the influence of a DC electric field and then filtering the measured ions by means of a quadrupole field in order to eliminate, or detect changes in, the mass-to-charge ratio. Several embodiments for the drift region are disclosed, in which the ions are kept in the axis of the drift region by RF fields. As these drift regions can also be utilized for a collision-induced decomposition of the ions, the device can additionally be used as a so-called triple quadrupole mass spectrometer.

摘要翻译： 质量选择的离子在气体中的迁移率通过在四极滤波器中根据其质荷比m / z选择正在研究的离子来测量几何百帕斯卡的压力，测量它们在压力下的漂移区域中的迁移率 在直流电场的影响下，几百帕斯卡，然后通过四极场过滤测量的离子，以消除或检测质荷比的变化。 公开了漂移区的几个实施例，其中通过RF场将离子保持在漂移区的轴上。 由于这些漂移区域也可以用于离子的碰撞诱导分解，因此该装置可另外用作所谓的三重四极杆质谱仪。

公开(公告)号：US20060284070A1

公开(公告)日：2006-12-21

申请号：US11440803

申请日：2006-05-25

申请人： Gokhan Baykut ,  Christian Berg ,  Jochen Franzen

发明人： Gokhan Baykut ,  Christian Berg ,  Jochen Franzen

IPC分类号： B01D59/44

CPC分类号： H01J49/38

摘要： The invention relates to methods and devices for regulating the filling level in measuring cells of ion cyclotron resonance mass spectrometers so that it is optimal for mass resolution and mass accuracy. The invention consists in supplying a fraction of the samples to a second reference mass spectrometer operated in parallel, and employing the mass spectra obtained from this reference mass spectrometer to regulate the filling level in the ion cyclotron resonance mass spectrometer.

公开(公告)号：US20080048113A1

公开(公告)日：2008-02-28

申请号：US11843753

申请日：2007-08-23

申请人： Jochen Franzen ,  Gokhan Baykut

发明人： Jochen Franzen ,  Gokhan Baykut

IPC分类号： H01J49/42

CPC分类号： H01J49/4225 ,  H01J49/063 ,  H01J49/4295

摘要： The invention relates to instruments for storing ions in more than one ion storage device and to the use of the storage bank thus created. The ion storage bank includes several storage cells configured as RF multipole rod systems, where the cells contain damping gas and are arranged in parallel. Each pair of pole rods is used jointly by two immediately adjacent storage cells such that the ions collected can be transported from one storage cell to the next by briefly applying DC or AC voltages to individual pairs of pole rods. The ions can thus be transported to storage cells in which they are fragmented or reactively modified, or from which they can be fed to other spectrometers. In particular, a circular arrangement of the storage cells on a virtual cylindrical surface makes it possible to accumulatively fill the storage cells with ions of specific fractions from temporally sequenced separation runs.

摘要翻译： 本发明涉及用于将离子存储在多于一个离子存储装置中的仪器以及由此产生的储存库的使用。 离子存储库包括配置为RF多极杆系统的多个存储单元，其中单元包含阻尼气体并且并联布置。 每对极杆由两个紧邻的存储单元联合使用，使得通过向单个极杆对简单地施加DC或AC电压，所收集的离子可以从一个存储单元传送到下一个存储单元。 因此，离子可以被运送到它们被分段或反应性修饰的存储单元中，或者从这些离子将它们送入其它光谱仪。 特别地，在虚拟圆柱形表面上的存储单元的圆形布置使得可以从时间上排序的分离行程累积地填充具有特定级分的离子的存储单元。

公开(公告)号：US20100207020A1

公开(公告)日：2010-08-19

申请号：US12637184

申请日：2009-12-14

申请人： Roland Jertz ,  Gokhan Baykut

发明人： Roland Jertz ,  Gokhan Baykut

IPC分类号： H01J49/34

CPC分类号： H01J49/38

摘要： The compensation potentials on the compensation electrodes of an ICR measuring cell are sequentially adjusted so that an ICR measurement with the longest possible usable image current transient is produced. Then, subsequent ICR measurements are made using the ICR cell with the optimally adjusted compensation potentials. Depending on the kind of ion mixture involved, measurements with image current transients from 10 to more than 20 seconds long can be performed, from which mass spectra with a maximum mass resolution without peak coalescence can be obtained.

摘要翻译： 依次调整ICR测量单元的补偿电极上的补偿电位，使得产生具有尽可能长的可用图像电流瞬变的ICR测量。 然后，使用具有最佳调整的补偿电位的ICR单元进行随后的ICR测量。 根据所涉及的离子混合物的种类，可以进行从10秒到20秒以上的图像电流瞬变的测量，从而可以获得具有最大质量分辨率而不具有峰值聚结的质谱。

公开(公告)号：US20090084948A1

公开(公告)日：2009-04-02

申请号：US11957613

申请日：2007-12-17

申请人： Gokhan Baykut ,  Roland Jert

发明人： Gokhan Baykut ,  Roland Jert

IPC分类号： B01D59/44

CPC分类号： H01J49/38 ,  G06Q10/0633 ,  H01J49/4265

摘要： In an ion cyclotron resonance mass spectrometer in which ions are trapped axially by applying electrical potentials to a pattern of electrode elements to produce an inhomogeneous alternating radio-frequency electric field with a repulsive effect, an additional electrostatic ion-attracting field is superimposed on the repulsive electric field. The voltage of the ion-attracting field is adjusted to compensate for a cyclotron frequency shift of the ions caused by the ion space charge. The voltage of the ion-attracting field can be adjusted so that the ion cyclotron frequency of all ions becomes independent of the number of ions inside the spectrometer.

摘要翻译： 在离子回旋共振质谱仪中，通过将电位施加到电极元件的图案以产生具有排斥效应的不均匀的交变射频电场，其中离子被轴向捕获，附加的静电离子吸引场叠加在排斥 电场。 调整离子吸引场的电压以补偿由离子空间电荷引起的离子的回旋加速器频移。 可以调节离子吸引场的电压，使得所有离子的离子回旋加速器的频率独立于光谱仪内的离子数。

公开(公告)号：US20140061458A1

公开(公告)日：2014-03-06

申请号：US11970125

申请日：2008-01-07

申请人： Gokhan Baykut

发明人： Gokhan Baykut

IPC分类号： H01J49/38 ,  H01J49/00 ,  H01J49/02

CPC分类号： H01J49/38 ,  H01J49/0031 ,  H01J49/025

摘要： In an ion cyclotron resonance cell, which is enclosed at its ends by electrode structure elements with DC voltages of alternating polarity, longitudinal electrodes are divided so that the ICR measurement cell between the electrode structure elements consists of at least three sections. An excitation of ion cyclotron motions can be performed by applying additional trapping voltages to longitudinal electrodes located closest to the electrode structure elements and introducing ions into the center set of longitudinal electrodes. The ions are then excited into cyclotron orbits by applying radiofrequency excitation pulses to at least two rows of longitudinal electrodes to produce orbiting ion clouds. Subsequently, the additional trapping voltages are removed and an ion-attracting DC voltage is superimposed on the DC voltages. Ions excited to circular orbits can be detected using detection electrodes in the outer ICR cell sections.

摘要翻译： 在离子回旋共振电池中，其电极结构元件由具有交替极性的直流电压的端部封闭，纵向电极被分割，使得电极结构元件之间的ICR测量单元由至少三个部分组成。 可以通过向最靠近电极结构元件的纵向电极施加附加的俘获电压并将离子引入纵向电极的中心集合中来执行离子回旋加速器运动的激发。 然后通过向至少两排纵向电极施加射频激发脉冲将离子激发到回旋加速器轨道中以产生轨道离子云。 随后，去除附加的捕获电压，并且在DC电压上叠加离子吸引的DC电压。 可以使用外部ICR细胞部分中的检测电极检测到圆周轨道激发的离子。

公开(公告)号：US20080042055A1

公开(公告)日：2008-02-21

申请号：US11506162

申请日：2006-08-17

申请人： Gokhan Baykut ,  Jonas Bergquist

发明人： Gokhan Baykut ,  Jonas Bergquist

IPC分类号： H01J49/40

CPC分类号： H01J49/0413 ,  G01N27/622

摘要： In an ion mobility spectrometer, ions are generated, mobility-separated and deposited on a receiver, preferably at spatially separated positions by soft landing or crash landing techniques. The ion mobility spectrometer can be a stand-alone instrument or part of a hybrid analysis instrument. To analyze the deposited ions, the receiver is removed from the vacuum system of the ion mobility spectrometer and introduced into an analytical instrument. Various physical, chemical, and biological analysis techniques and instrumentation can be used, such as mass spectrometry or surface analytical techniques, by selecting a special receiver suitable for the desired analytical technique.

摘要翻译： 在离子迁移谱仪中，产生离子，迁移率分离并沉积在接收器上，优选通过软着陆或碰撞着陆技术在空间分离的位置。 离子迁移谱仪可以是独立仪器或混合分析仪器的一部分。 为了分析沉积的离子，将接收器从离子迁移谱仪的真空系统中去除并引入分析仪器中。 通过选择适合于所需分析技术的特殊接收器，可以使用各种物理，化学和生物分析技术和仪器，如质谱法或表面分析技术。

公开(公告)号：US5825026A

公开(公告)日：1998-10-20

申请号：US896207

申请日：1997-07-17

申请人： Gokhan Baykut

发明人： Gokhan Baykut

IPC分类号： H01J49/42 ,  H01J49/00

CPC分类号： H01J49/063 ,  H01J49/107

摘要： Curved rf multipole ion guides or angled linear rf multipole ion guides are designed to be rotatable or shiftable. Thus, the direction of guided ions can be altered by rotating or shifting these ion guides. In a mass spectrometer equipped with a multitude of ion sources, this allows to switch between ion sources without venting the vacuum system.

摘要翻译： 弯曲的rf多极离子导向器或成角度的线性rf多极离子导向器设计为可旋转或可移动。 因此，通过旋转或移动这些离子导向器可以改变引导离子的方向。 在配备有大量离子源的质谱仪中，可以在离子源之间进行切换，而无需排空真空系统。