公开(公告)号：US6008644A

公开(公告)日：1999-12-28

申请号：US888317

申请日：1997-07-03

申请人： Ib Leunbach ,  Ian Young ,  Gosta Ehnholm ,  Georg Hansson ,  Stefan Petersson ,  Lars-Goran Wistrand ,  Klaes Golman

发明人： Ib Leunbach ,  Ian Young ,  Gosta Ehnholm ,  Georg Hansson ,  Stefan Petersson ,  Lars-Goran Wistrand ,  Klaes Golman

IPC分类号： B82B1/00 ,  A61B5/055 ,  G01N24/12 ,  G01R33/28 ,  G01R33/62 ,  G01V3/00

CPC分类号： G01R33/5601 ,  G01R33/282 ,  G01R33/62

摘要： This invention relates to a method of electron spin resonance enhanced magnetic resonance imaging which relies on ex vivo dynamic nuclear polarisation of an MR imaging agent.

摘要翻译： 本发明涉及依赖于MR成像剂的离体动态核极化的电子自旋共振增强磁共振成像方法。

公开(公告)号：US07701220B2

公开(公告)日：2010-04-20

申请号：US11720874

申请日：2005-12-05

申请人： Gosta Ehnholm

发明人： Gosta Ehnholm

IPC分类号： G01V3/00

CPC分类号： G01R33/3692 ,  G01R33/3415 ,  G01R33/3621

摘要： A coils array (40, 40′) including a plurality of coils (71, 72, 73) receives magnetic resonance signals from an examination region of a magnetic resonance imaging scanner (10). Each coil has mixing circuitry (74, 75, 76, 80, 81, 82) that frequency-shifts the received magnetic resonance signal to a selected transmission channel frequency. The coils array further includes combining circuitry (90) that combines the frequency-shifted magnetic resonance signals to produce an analog frequency domain multiplexed transmission signal output of the coils array. Receiver electronics (56, 56″) receive the analog frequency domain multiplexed transmission signal from the coils array. The receiver electronics include an analog-to-digital converter (164) that digitizes the analog frequency domain multiplexed transmission signal and digital signal processing circuitry (166) that processes the digital frequency domain multiplexed transmission signal to recover digitized signals corresponding to the magnetic resonance signals received by the plurality of coils.

摘要翻译： 包括多个线圈（71,72,73）的线圈阵列（40,40'）从磁共振成像扫描仪（10）的检查区域接收磁共振信号。 每个线圈具有将接收到的磁共振信号频率移位到所选择的传输信道频率的混合电路（74,75,76,80,81,82）。 线圈阵列还包括组合电路（90），其组合频移磁共振信号以产生线圈阵列的模拟频域复用传输信号输出。 接收器电子器件（56,56“）从线圈阵列接收模拟频域多路传输信号。 接收机电子设备包括数字化模拟频域复用传输信号的模数转换器（164）和处理数字频域复用传输信号的数字信号处理电路（166），以恢复对应于磁共振信号的数字化信号 由多个线圈接收。

公开(公告)号：US10058718B2

公开(公告)日：2018-08-28

申请号：US13202602

申请日：2010-02-05

申请人： Shriram Sethuraman ,  Gosta Ehnholm ,  Balasundara I. Raju

发明人： Shriram Sethuraman ,  Gosta Ehnholm ,  Balasundara I. Raju

IPC分类号： A61H1/00 ,  A61N7/02 ,  A61B17/00 ,  A61B18/00 ,  A61B90/00

CPC分类号： A61N7/022 ,  A61B2017/00911 ,  A61B2018/00023 ,  A61B2090/0472 ,  A61B2090/374

摘要： A probe including a shaft on which an ultrasound element is mounted, an outer sheath and an acoustic membrane surrounding the shaft and the ultrasound element such that the shaft and ultrasound element are rotatable therein. Passages may supply a cooling and acoustic coupling fluid to an inlet and outlet adjacent the acoustic element to cool the acoustic element and fill a volume between the acoustic element and the acoustic sheath with the fluid. A balloon may be mounted on the probe to be selectively inflated to fix a position of the probe. A drain for urine and other bodily fluids may be provided through the probe.

公开(公告)号：US20110301508A1

公开(公告)日：2011-12-08

申请号：US13202602

申请日：2010-02-05

申请人： Shriram Sethuraman ,  Gosta Ehnholm ,  Balasundara I. Raju

发明人： Shriram Sethuraman ,  Gosta Ehnholm ,  Balasundara I. Raju

IPC分类号： A61N7/00

CPC分类号： A61N7/022 ,  A61B2017/00911 ,  A61B2018/00023 ,  A61B2090/0472 ,  A61B2090/374

摘要： A probe (40) includes a shaft (52) on which an ultrasound element (42) is mounted. An outer sheath (64) and an acoustic membrane (66) surround the shaft and the ultrasound element such that the shaft and ultrasound element are rotatable therein. Passages (56) supply a cooling and acoustic coupling fluid to an inlet and outlet (48) adjacent the acoustic element to cool the acoustic element and fill a volume between the acoustic element and the acoustic sheath with the fluid. A balloon (90) mounted on the probe is selectively inflated in order to fix a position of the probe. A drain (94, 98) drains urine and other bodily fluids through the probe.

摘要翻译： 探针（40）包括其上安装有超声波元件（42）的轴（52）。 围绕轴和超声波元件的外护套（64）和声膜（66）使得轴和超声元件能够在其中旋转。 通道（56）将冷却和声耦合流体提供给邻近声学元件的入口和出口（48），以冷却声学元件并用流体填充声学元件和声学护套之间的体积。 安装在探针上的球囊（90）选择性地膨胀以固定探针的位置。 排水口（94,98）通过探头排出尿液和其他体液。

公开(公告)号：US20090069667A1

公开(公告)日：2009-03-12

申请号：US12296769

申请日：2007-03-16

申请人： Matti Lindstrom ,  Gosta Ehnholm

发明人： Matti Lindstrom ,  Gosta Ehnholm

IPC分类号： A61B5/055 ,  A61N7/00

CPC分类号： A61B17/2255 ,  A61B5/0555 ,  A61B8/00 ,  A61B8/4416 ,  A61B34/20 ,  A61B34/70 ,  A61B90/10 ,  A61B2017/00084 ,  A61B2017/00128 ,  A61B2017/00199 ,  A61B2017/00911 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2090/374 ,  A61N7/02 ,  A61N7/022 ,  G06F19/00

摘要： A device (16) positions an ultrasound transducer (14) for ultrasound therapy to focus a treatment beam (12) emitted by the ultrasound transducer (14) at tissue of interest. The device (16) includes at least three anchors (20) which support the ultrasound transducer (14). The device (16) further includes at least three extendable structures (24), each with a coupling (22) that supports a corresponding one of the at least three anchors (20). A drive mechanism (100) of the device (16) independently drives each of the at least three extendable structures (24) towards or away from a subject to move the ultrasound transducer (14) within at least three degrees of freedom.

摘要翻译： 设备（16）定位用于超声治疗的超声换能器（14），以将由超声换能器（14）发射的治疗束（12）聚焦在感兴趣的组织上。 装置（16）包括支撑超声换能器（14）的至少三个锚（20）。 装置（16）还包括至少三个可延伸结构（24），每个可延伸结构（24）均具有支撑至少三个锚固件（20）中相应的一个的连接件（22）。 装置（16）的驱动机构（100）独立地驱动至少三个可延伸结构（24）中的每一个朝向或远离受试者，以将超声换能器（14）移动至少三个自由度。

公开(公告)号：US4596931A

公开(公告)日：1986-06-24

申请号：US596295

申请日：1984-04-03

申请人： Gosta Ehnholm ,  Matti Hakala ,  Tapio Uimonen

发明人： Gosta Ehnholm ,  Matti Hakala ,  Tapio Uimonen

IPC分类号： G01D3/02 ,  G01D3/04

CPC分类号： G01D3/02

摘要： The invention relates to a method of eliminating the effect of temperature, air pressure and/or a disturbing material component or a like parameter in photometric analysis in which is generated a so-called dark signal, the passage of emitted radiation for detection being blocked at that time, a reference signal for one or more material components to be measured, said reference signal not being affected by said material component to be measured, as well as for each material component to be measured a measuring signal representing the amount of material component to be measured. According to the invention, whenever the difference between a reference signal and a measuring signal changes due to a change in any of the above parameters, there is generated a control signal which represents said parametric change and is proportional thereto, said control signal serving to change the difference between a reference signal and a dark signal in order to compensate for said parametric change. The material components to be measured may preferably comprise CO.sub.2, N.sub.2 O and/or one or more anesthetic gases.

摘要翻译： 本发明涉及一种在光度分析中消除温度，空气压力和/或干扰材料成分等参数的影响的方法，其中产生所谓的暗信号，用于检测的发射辐射的通过被阻挡在 该时间，用于待测量的一种或多种材料组分的参考信号，所述参考信号不受待测量的所述材料组分的影响，并且对于待测量的每种材料组分，表示材料组分的量的测量信号 被测量。 根据本发明，只要参考信号和测量信号之间的差异由于上述任何参数的变化而变化，就产生一个表示所述参数变化并与其成比例的控制信号，所述控制信号用于改变 参考信号和暗信号之间的差异，以补偿所述参数变化。 待测量的材料组分可优选包含CO 2，N 2 O和/或一种或多种麻醉气体。

公开(公告)号：US09526515B2

公开(公告)日：2016-12-27

申请号：US12296769

申请日：2007-03-16

申请人： Matti Lindstrom ,  Gosta Ehnholm

发明人： Matti Lindstrom ,  Gosta Ehnholm

IPC分类号： A61B5/05 ,  A61B17/225 ,  A61B8/00 ,  A61B17/00 ,  A61N7/02

CPC分类号： A61B17/2255 ,  A61B5/0555 ,  A61B8/00 ,  A61B8/4416 ,  A61B34/20 ,  A61B34/70 ,  A61B90/10 ,  A61B2017/00084 ,  A61B2017/00128 ,  A61B2017/00199 ,  A61B2017/00911 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2090/374 ,  A61N7/02 ,  A61N7/022 ,  G06F19/00

摘要： A device (16) positions an ultrasound transducer (14) for ultrasound therapy to focus a treatment beam (12) emitted by the ultrasound transducer (14) at tissue of interest. The device (16) includes at least three anchors (20) which support the ultrasound transducer (14). The device (16) further includes at least three extendable structures (24), each with a coupling (22) that supports a corresponding one of the at least three anchors (20). A drive mechanism (100) of the device (16) independently drives each of the at least three extendable structures (24) towards or away from a subject to move the ultrasound transducer (14) within at least three degrees of freedom.

摘要翻译： 设备（16）定位用于超声治疗的超声换能器（14），以将由超声换能器（14）发射的治疗束（12）聚焦在感兴趣的组织上。 装置（16）包括支撑超声换能器（14）的至少三个锚（20）。 装置（16）还包括至少三个可延伸结构（24），每个可延伸结构（24）均具有支撑至少三个锚固件（20）中相应的一个的连接件（22）。 装置（16）的驱动机构（100）独立地驱动至少三个可延伸结构（24）中的每一个朝向或远离受试者，以将超声换能器（14）移动至少三个自由度。

公开(公告)号：US20090230966A1

公开(公告)日：2009-09-17

申请号：US11720874

申请日：2005-12-05

申请人： Gosta Ehnholm

发明人： Gosta Ehnholm

IPC分类号： G01R33/3415

CPC分类号： G01R33/3692 ,  G01R33/3415 ,  G01R33/3621

摘要： A coils array (40, 40′) including a plurality of coils (71, 72, 73) receives magnetic resonance signals from an examination region of a magnetic resonance imaging scanner (10). Each coil has mixing circuitry (74, 75, 76, 80, 81, 82) that frequency-shifts the received magnetic resonance signal to a selected transmission channel frequency. The coils array further includes combining circuitry (90) that combines the frequency-shifted magnetic resonance signals to produce an analog frequency domain multiplexed transmission signal output of the coils array. Receiver electronics (56, 56″) receive the analog frequency domain multiplexed transmission signal from the coils array. The receiver electronics include an analog-to-digital converter (164) that digitizes the analog frequency domain multiplexed transmission signal and digital signal processing circuitry (166) that processes the digital frequency domain multiplexed transmission signal to recover digitized signals corresponding to the magnetic resonance signals received by the plurality of coils.

摘要翻译： 包括多个线圈（71,72,73）的线圈阵列（40,40'）从磁共振成像扫描仪（10）的检查区域接收磁共振信号。 每个线圈具有将接收到的磁共振信号频率移位到所选择的传输信道频率的混合电路（74,75,76,80,81,82）。 线圈阵列还包括组合电路（90），其组合频移磁共振信号以产生线圈阵列的模拟频域复用传输信号输出。 接收机电子设备（56,56“）从线圈阵列接收模拟频域复用的传输信号。 接收机电子设备包括数字化模拟频域复用传输信号的模数转换器（164）和处理数字频域复用传输信号的数字信号处理电路（166），以恢复对应于磁共振信号的数字化信号 由多个线圈接收。

公开(公告)号：US20070219443A1

公开(公告)日：2007-09-20

申请号：US11574520

申请日：2005-08-25

申请人： Gosta Ehnholm ,  Matti Lindstrom

发明人： Gosta Ehnholm ,  Matti Lindstrom

IPC分类号： A61B5/055 ,  G01R33/28

CPC分类号： G01R33/28 ,  A61B5/055 ,  A61B5/06 ,  A61B5/7257 ,  A61B2090/3954 ,  G01R33/285

摘要： A magnetic resonance position and orientation marking system includes fiducial assembly (30) with at least three fiducial markers (31, 32, 33) each coupled with at least one magnetic resonance receive coil (70, 74, 80, 84). At least one of the fiducial markers has at least one of: (i) marker nuclei selectively excitable over 1H fat and water resonance, 5 and (ii) a plurality of magnetic resonance receive coils (70, 84) coupled therewith. At least two magnetic resonance receive channels (40, 42) receive magnetic resonance signals from the at least three fiducial markers (31, 32, 33) responsive to excitation of magnetic resonance in said at least three fiducial markers by a magnetic resonance imaging scanner (10).

摘要翻译： 磁共振位置和取向标记系统包括具有至少三个基准标记（31,32,33）的基准组件（30），每个基准标记（31,32,33）与至少一个磁共振接收线圈（70,74,80,94）耦合。 至少一个基准标记具有以下至少一个：（i）标记核可以通过1 H脂肪和水共振5选择性地激发，和（ii）多个磁共振接收线圈（70， 84）。 至少两个磁共振接收通道（40,42）响应于在所述至少三个基准标记中的磁共振的激发而通过磁共振成像扫描器（30,32）接收来自至少三个基准标记（31,32,33）的磁共振信号 10）。

公开(公告)号：US5537040A

公开(公告)日：1996-07-16

申请号：US362735

申请日：1994-12-22

申请人： Gosta Ehnholm

发明人： Gosta Ehnholm

IPC分类号： G01N20060101 ,  G01N24/08 ,  G01R33/20 ,  G01R33/38 ,  G01R33/48

CPC分类号： G01R33/3806 ,  G01R33/381 ,  G01R33/383 ,  G01R33/445

摘要： In an apparatus and method for magnetic resonance imaging, an imaging field (B.sub.p) and a pre-polarization field (B.sub.p) are generated by means of electromagnetic coils ALC in an air gap between pole pieces of a magnet core. The pole pieces are designed such that, as the current in the coils is increased, the field strength increases only in the central area between pole pieces up to the strength (B.sub.p) of the pre-polarization field. This is due to the saturation of the edge zones of pole pieces that restricts the increase of field strength in the edge zones of the air gap.

摘要翻译： 在用于磁共振成像的装置和方法中，通过电磁线圈ALC在磁芯的极片之间的气隙中产生成像场（Bp）和预极化场（Bp）。 极片被设计成使得当线圈中的电流增加时，场强仅在极片之间的中心区域增加直到预极化场的强度（Bp）。 这是由于极片的边缘区域的饱和，这限制了气隙边缘区域的场强增加。