公开(公告)号：US06607631B1

公开(公告)日：2003-08-19

申请号：US09657912

申请日：2000-09-08

申请人： Ibraheem T. Badejo ,  Wendy Y. Su ,  Keith R. D'Alessio ,  Jerry Jonn ,  Julian A. Quintero ,  Michelle Knotts ,  Timothy P. Hickey ,  Lawrence H. Mainwaring ,  Upvan Narang

发明人： Ibraheem T. Badejo ,  Wendy Y. Su ,  Keith R. D'Alessio ,  Jerry Jonn ,  Julian A. Quintero ,  Michelle Knotts ,  Timothy P. Hickey ,  Lawrence H. Mainwaring ,  Upvan Narang

IPC分类号： C09J18304

CPC分类号： A61L24/06 ,  C09J4/00 ,  C08L35/04 ,  C08F222/32

摘要： A polymerizable monomer adhesive composition includes a 1,1-disubstituted ethylene monomer and at least one slip additive, where the slip additive causes a polymer film formed from the monomer to have a lower coefficient of friction than in an absence of the slip additive. The slip additive can be selected from, inter alia, fluorinated monomers or polymers, fluorinated additives, siloxane-containing monomers or polymers, siloxane-containing additives, fluorinated siloxanes, and long chain fatty acid esters. The slip additive can also form a second phase in a resultant polymer film, where the second phase is soluble in the monomer but is insoluble or substantially insoluble in the polymer.

摘要翻译： 可聚合单体粘合剂组合物包括1,1-双取代的乙烯单体和至少一种滑爽添加剂，其中滑爽添加剂使得由单体形成的聚合物膜的摩擦系数低于不存在滑爽添加剂的摩擦系数。 滑爽添加剂尤其可以选自氟化单体或聚合物，氟化添加剂，含硅氧烷的单体或聚合物，含硅氧烷的添加剂，氟化硅氧烷和长链脂肪酸酯。 滑爽添加剂还可以在所得聚合物膜中形成第二相，其中第二相可溶于单体，但不溶或基本上不溶于聚合物。

公开(公告)号：US06595940B1

公开(公告)日：2003-07-22

申请号：US09430290

申请日：1999-10-29

申请人： Keith R. D'Alessio ,  William M. Cotter ,  Upvan Narang ,  Lawrence H. Mainwaring ,  Ibraheem T. Badejo ,  Daniel L. Hedgpeth ,  Gabriel N. Szabo ,  Anthony Sherbondy ,  Joe B. Barefoot

发明人： Keith R. D'Alessio ,  William M. Cotter ,  Upvan Narang ,  Lawrence H. Mainwaring ,  Ibraheem T. Badejo ,  Daniel L. Hedgpeth ,  Gabriel N. Szabo ,  Anthony Sherbondy ,  Joe B. Barefoot

IPC分类号： A61M3500

CPC分类号： A61M35/003

摘要： A disposable applicator includes a generally tubular applicator body having a closed proximal end and an open distal end and a frangible vial inside. The proximal end is covered by a drying swab while the distal end is covered by an applicator swab that is in open communication with the interior of the applicator body. Within the applicator body is a frangible vial containing a biomedically useful liquid composition, such as an &agr;-cyanoacrylate adhesive, a medicament, or both. The applicator is useful for applying liquid compositions to target sites such as tissue, particularly sites of topical pathology, such as stomatitis lesions.

摘要翻译： 一次性涂抹器包括一个大致管状的施用器主体，其具有封闭的近端和敞开的远端以及内部易碎的小瓶。 近端由干燥棉签覆盖，而远端由与施用器主体内部开放连通的施用器拭子覆盖。 在施用器主体内是具有生物医学上可用的液体组合物的易碎小瓶，例如α-氰基丙烯酸酯粘合剂，药物或两者。 施用器可用于将液体组合物施用于靶点，例如组织，特别是局部病理部位，例如口腔炎病变。

公开(公告)号：US06579469B1

公开(公告)日：2003-06-17

申请号：US09430180

申请日：1999-10-29

申请人： William S. C. Nicholson ,  Upvan Narang ,  Ubonwan A. Stewart ,  Daniel L. Hedgpeth ,  Ibraheem T. Badejo ,  Lawrence H. Mainwaring

发明人： William S. C. Nicholson ,  Upvan Narang ,  Ubonwan A. Stewart ,  Daniel L. Hedgpeth ,  Ibraheem T. Badejo ,  Lawrence H. Mainwaring

IPC分类号： C09K300

CPC分类号： A61L24/06 ,  A61L24/001 ,  C08F22/32 ,  C09J4/00 ,  C08L35/04 ,  C08F222/32

摘要： An adhesive composition that contains a preservative is particularly useful as a medical adhesive and can include alkyl cyanoacrylate monomers. The preservative is preferably soluble in the monomer. The composition may optionally be sterilized by placing a mixture of a polymerizable adhesive monomer and a preservative in a container, sealing the container, and sterilizing the mixture and the container.

摘要翻译： 包含防腐剂的粘合剂组合物特别可用作医用粘合剂，并且可以包括氰基丙烯酸烷基酯单体。 防腐剂优选溶于单体中。 组合物可以任选地通过将可聚合粘合剂单体和防腐剂的混合物放置在容器中，密封容器以及对混合物和容器进行灭菌来灭菌。

公开(公告)号：US06779657B2

公开(公告)日：2004-08-24

申请号：US09874039

申请日：2001-06-06

申请人： Lawrence H. Mainwaring ,  Upvan Narang

发明人： Lawrence H. Mainwaring ,  Upvan Narang

IPC分类号： B65D6900

CPC分类号： B65D25/08 ,  B65D81/3294

摘要： A single-use applicator assembly for dispensing and applying a polymerizable monomeric adhesive material includes: a base portion having at least one sealed compartment; a polymerizable monomeric adhesive material contained in the compartment; an applicator at least partially disposed in the compartment such that a tip of the applicator is proximate the adhesive material. The at least one sealed compartment may comprise first and second sealed compartments that are separated with the polymerizable monomeric adhesive material contained in the first compartment and the applicator at least partially disposed in the second compartment. Alternatively, the first and second compartments may be open to each other. In such case, the applicator assembly may further comprise a plunger that defines the second compartment and that is movable into the first compartment to displace the adhesive material into the second compartment. A kit can include multiple applicator assemblies that are separate or frangibly connected.

摘要翻译： 用于分配和施加可聚合单体粘合剂材料的一次性涂抹器组件包括：具有至少一个密封隔室的基部; 容纳在隔室中的可聚合单体粘合剂材料; 至少部分地设置在所述隔室中的施用器，使得所述施用器的尖端靠近所述粘合剂材料。 所述至少一个密封隔室可以包括第一和第二密封隔室，所述第一和第二密封隔室与包含在第一隔室中的可聚合单体粘合剂材料分开，并且施用器至少部分地设置在第二隔室中。 或者，第一和第二隔室可以彼此敞开。 在这种情况下，施用器组件还可以包括限定第二隔室并且可移动到第一隔室中以将粘合剂材料移位到第二隔室中的柱塞。 套件可以包括分开的或者是脆弱连接的多个施加器组件。

公开(公告)号：US06494896B1

公开(公告)日：2002-12-17

申请号：US09450686

申请日：1999-11-30

申请人： Keith R. D'Alessio ,  Lawrence H. Mainwaring

发明人： Keith R. D'Alessio ,  Lawrence H. Mainwaring

IPC分类号： A61B1704

CPC分类号： A61B17/00491 ,  A61B17/00234 ,  A61B17/30 ,  A61B2017/00535 ,  A61B2017/3488

摘要： A hand-held applicator delivers liquid or semi-liquid compositions, such as adhesives, to an internal tissue or organ in an even and controlled manner. The applicator includes a pump, a tubular extension that is thin enough to pass through an endoscopic pathway or trocar, a proximal end of the tubular extension being sealingly connected to the pump, and an applicator tip that attaches to the distal end of the tubular extension. The tip includes the liquid and the pump pumps the liquid to the internal tissue in an even and controlled manner without contact of the liquid by the pump. The pump is preferably a micropipetter that includes a hand-held portion having a hand-actuatable plunger that does not come in direct, physical contact with the liquid to be dispensed. The composition may be an adhesive such as an alpha-cyanoacrylate. The device may further include a wound closure device including at least two closure pins extending from the distal end of the tubular extension. The wound closure device retracts from the applicator device and orients and aligns a wound or incision target tissue site immediately prior to application of the medical composition. The device provides improved control, ergonomics, and convenience. The device is particularly useful in the field of surgery, especially in the field of laparoscopic or endoscopic surgery, where an even and controlled amount of a medically-acceptable adhesive is to be applied to a target site on an internal tissue or organ.

摘要翻译： 手持式施药器以均匀和受控的方式将液体或半液体组合物（例如粘合剂）递送至内部组织或器官。 施用器包括泵，足够薄以穿过内窥镜通路或套管针的管状延伸部，管状延伸部的近端密封地连接到泵，以及附接到管状延伸部的远端的施用器末端 。 尖端包括液体，并且泵以均匀且受控的方式将液体泵送到内部组织，而不会被泵与液体接触。 泵优选地是微量吸嘴，其包括手持部分，其具有手动致动柱塞，其不会与待分配的液体直接地物理接触。 组合物可以是诸如α-氰基丙烯酸酯的粘合剂。 所述装置还可以包括伤口闭合装置，其包括从所述管状延伸部的远端延伸的至少两个闭合销。 伤口闭合装置从施用器装置缩回并且在施用医疗组合物之前定向和对准伤口或切口目标组织部位。 该设备提供改进的控制，人体工程学和便利性。 该装置在手术领域特别有用，特别是在腹腔镜或内窥镜手术领域中，其中均匀和受控量的医学上可接受的粘合剂应用于内部组织或器官上的靶位点。