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    Method of immunological assaying human osteocalcin, reagent and kit therefor, antibody to human osteocalcin, hybridoma producing said antibody, and method of producing it
    2.
    发明授权
    Method of immunological assaying human osteocalcin, reagent and kit therefor, antibody to human osteocalcin, hybridoma producing said antibody, and method of producing it 失效
    免疫学测定方法人骨钙蛋白，其试剂和试剂盒，抗人骨钙素抗体，产生所述抗体的杂交瘤及其生产方法

    公开(公告)号：US5681707A

    公开(公告)日：1997-10-28

    申请号：US465348

    申请日：1995-06-05

    申请人： Kenji Hosoda ,  Hitomi Honda ,  Takaharu Kubota ,  Yasuhiko Masuho

    发明人： Kenji Hosoda ,  Hitomi Honda ,  Takaharu Kubota ,  Yasuhiko Masuho

    IPC分类号： C07K14/78 ,  C07K16/18 ,  G01N33/68 ,  G01N33/535

    CPC分类号： C07K14/78 ,  C07K16/18 ,  G01N33/6887 ,  G01N2800/108 ,  Y10S435/975

    摘要： A method of immunologically assaying intact human osteocalcin in a human assay sample is provided by using an antibody having an epitope in a region of an amino acid sequence 1 to 20 on the N-terminal side of human osteocalcinand an antibody having an epitope in a region of an amino acid sequence 36 to 49 on the C-terminal side of human osteocalcin. Furthermore, a method of immunologically assaying the total amount of human intact osteocalcin in a human assay sample is provided. A reagent and a kit therefor are also described, as well as a monclonal antibody and a polyclonal antibody used for the assay a process for producing these antibodies; and a process for use of these antibodies.

    摘要翻译： 通过使用具有在人骨钙蛋白的N末端侧上具有1至20个氨基酸的区域中的表位的抗体和在区域​​中具有表位的抗体来提供在人测定样品中免疫测定完整人骨钙素的方法 的人骨钙蛋白C末端侧的氨基酸序列36〜49。 此外，提供了在人测定样品中免疫测定人完整骨钙素总量的方法。 还描述了一种试剂及其试剂盒，以及用于测定生产这些抗体的方法的单克隆抗体和多克隆抗体; 以及使用这些抗体的方法。

    Method of immunological assaying of human osteocalcin, reagent and kit therefor, antibody to human osteocalcin, hybridoma producing said antibody, and method of producing it
    3.
    发明授权
    Method of immunological assaying of human osteocalcin, reagent and kit therefor, antibody to human osteocalcin, hybridoma producing said antibody, and method of producing it 失效
    人骨钙蛋白的免疫学测定方法，其试剂及试剂盒，人骨钙蛋白抗体，产生所述抗体的杂交瘤及其生产方法

    公开(公告)号：US5506111A

    公开(公告)日：1996-04-09

    申请号：US316364

    申请日：1994-10-03

    申请人： Kenji Hosoda ,  Hitomi Honda ,  Takaharu Kubota ,  Yasuhiko Masuho

    发明人： Kenji Hosoda ,  Hitomi Honda ,  Takaharu Kubota ,  Yasuhiko Masuho

    IPC分类号： C07K14/78 ,  C07K16/18 ,  G01N33/68 ,  G01N33/53

    CPC分类号： C07K14/78 ,  C07K16/18 ,  G01N33/6887 ,  G01N2800/108 ,  Y10S435/975

    摘要： A method of immunologically assaying intact human osteocalcin in a human assay sample is provided by using an antibody having an epitope in a region of an amino acid sequence 1 to 20 on the N-terminal side of human osteocalcin and an antibody having an epitope in a region of an amino acid sequence 36 to 49 on the C-terminal side of human osteocalcin. A reagent and a kit therefor are provided. Furthermore, a method of immunologically assaying the total amount of human intact osteocalcin in a human assay sample, and a reagent and a kit therefor are also provided. A monoclonal antibody and a polyclonal antibody are used for the assay. A process for producing these antibodies, and utilization of these antibodies is described.

    摘要翻译： 通过使用具有在人骨钙蛋白的N末端侧上具有1至20个氨基酸的区域中的表位的抗体和在其中具有表位的抗体来提供在人测定样品中免疫测定完整人骨钙蛋白的方法 在人骨钙蛋白的C末端侧的氨基酸序列36〜49的区域。 提供了一种试剂及其试剂盒。 此外，还提供了在人测定样品中免疫测定人完整骨钙素总量的方法，以及试剂及其试剂盒。 单克隆抗体和多克隆抗体用于测定。 描述了制备这些抗体的方法和这些抗体的利用。

    Method of determining human acid glutathione S-transferase, reagent, therefor, kit therefor, method of diagnosing cancer in digestive organs, and monoclonal antibody for use therein
    4.
    发明授权
    Method of determining human acid glutathione S-transferase, reagent, therefor, kit therefor, method of diagnosing cancer in digestive organs, and monoclonal antibody for use therein 失效
    确定人酸谷胱甘肽S-转移酶的方法，其试剂，用于其的试剂盒，消化器官中的癌症诊断方法和用于其中的单克隆抗体

    公开(公告)号：US5427917A

    公开(公告)日：1995-06-27

    申请号：US169963

    申请日：1993-12-20

    申请人： Kenji Hosoda ,  Hitomi Honda ,  Takaharu Kubota ,  Hideaki Suzuki

    发明人： Kenji Hosoda ,  Hitomi Honda ,  Takaharu Kubota ,  Hideaki Suzuki

    IPC分类号： C07K16/30 ,  C07K16/40 ,  G01N33/53

    CPC分类号： G01N33/5306 ,  C07K16/3046 ,  C07K16/40

    摘要： A method of immunologically determining human acid glutathione S-transferase in a human assay sample, which comprises bringing the assay sample into contact with a first antibody bound to an insoluble solid carrier and a labelled second antibody, either the first or second antibody being a polyclonal antibody capable of recognizing human acid glutathione S-transferase or an equivalent fragment of the polyclonal antibody, and the other antibody being a monoclonal antibody capable of specifically recognizing human acid glutathione S-transferase or an equivalent fragment of the monoclonal antibody, a method of diagnosing cancer in a human digestive organ by using the above method, a reagent therefor, a kit therefor and a monoclonal antibody for use therein.

    摘要翻译： 一种在人测定样品中免疫测定人酸谷胱甘肽S-转移酶的方法，其包括使测定样品与结合于不溶性固体载体和标记的第二抗体的第一抗体接触，所述第一或第二抗体是多克隆 能够识别人酸谷胱甘肽S-转移酶或多克隆抗体的等同片段的抗体，另一抗体是能够特异性识别人酸谷胱甘肽S-转移酶或单克隆抗体的等同片段的单克隆抗体，诊断方法 通过使用上述方法的人类消化器官中的癌症，其试剂，用于其的试剂盒和用于其中的单克隆抗体。

    Immunoassay and reagent kit used therefor
    5.
    发明授权
    Immunoassay and reagent kit used therefor 失效
    用于此的免疫测定和试剂盒

    公开(公告)号：US5366861A

    公开(公告)日：1994-11-22

    申请号：US26110

    申请日：1993-03-01

    申请人： Kenji Hosoda ,  Takaharu Kubota ,  Hitomi Honda ,  Hideaki Suzuki

    发明人： Kenji Hosoda ,  Takaharu Kubota ,  Hitomi Honda ,  Hideaki Suzuki

    IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/86 ,  C12Q1/00 ,  C12Q1/48 ,  G01N33/536

    CPC分类号： G01N33/5306 ,  G01N33/54393 ,  G01N33/86 ,  G01N2333/745 ,  G01N2333/81 ,  G01N2333/96461 ,  Y10S435/975

    摘要： An immunoassay method performed in solution wherein a protein having an average molecular weight of 16,000 to 50,000 and an isoelectric point of 1.0 to 5.0 or a mixture containing the same is permitted to exist as the antigen-antibody reaction controller in the immunoreaction solution, and the final concentration of the antigen-antibody controller in the immunoreaction solution is controlled to 0.02 to 0.9% by weight, and a reagent kit to be used for an immunoassay containing the above antigen-antibody reaction controller at a final concentration of 0.02 to 0.9% by weight in the immunoreaction solution, as a part of the constituents thereof.

    摘要翻译： 在溶液中进行的免疫测定方法，其中允许平均分子量为16,000至50,000，等电点为1.0至5.0的蛋白质或含有该蛋白质的混合物作为免疫反应溶液中的抗原 - 抗体反应控制剂存在， 将免疫反应溶液中的抗原 - 抗体控制剂的终浓度控制在0.02〜0.9重量％，将试剂盒用于含有上述抗原 - 抗体反应控制剂的终浓度为0.02〜0.9％的免疫测定 免疫反应溶液中的重量，作为其成分的一部分。

    Stroke amount detecting device
    7.
    发明授权
    Stroke amount detecting device 有权
    行程量检测装置

    公开(公告)号：US08558539B2

    公开(公告)日：2013-10-15

    申请号：US13082788

    申请日：2011-04-08

    申请人： Koichiro Matsumoto ,  Yoshiyuki Kono ,  Hitomi Honda

    发明人： Koichiro Matsumoto ,  Yoshiyuki Kono ,  Hitomi Honda

    IPC分类号： G01B7/14

    CPC分类号： G01D5/145

    摘要： A stroke amount detecting device includes a first magnetic field generation member, a second magnetic field generation member, and a magnetic sensor unit. The first magnetic field generation member and the second magnetic field generation member are opposed to each other with respect to a direction perpendicular to a straight stroking axis of a stroking object, and magnetized in opposite directions. The magnetic sensor unit is movable in an area between the first magnetic field generation member and the second magnetic field generation member, along a straight traveling axis that is parallel to the straight stroking axis relative to the first magnetic field generation member and the second magnetic field generation member in accordance with a stroke motion of the stroking object. The magnetic sensor unit has a magnetosensitive surface facing a direction parallel to the traveling axis, thereby to detect an amount of stroke of the object.

    摘要翻译： 行程量检测装置包括第一磁场产生部件，第二磁场产生部件和磁传感器部件。 第一磁场产生部件和第二磁场产生部件相对于与抚摸物体的直线行进轴垂直的方向相互相对，并且沿相反方向磁化。 磁传感器单元可沿第一磁场产生部件和第二磁场产生部件之间的区域沿着相对于第一磁场产生部件与直线行程轴平行的直线行进轴移动，第二磁场 根据抚摸物体的行程运动产生构件。 磁传感器单元具有面向与行进轴平行的方向的磁感应表面，从而检测物体的行程。

    Rotation angle detector
    8.
    发明授权
    Rotation angle detector 有权
    旋转角度检测器

    公开(公告)号：US08566063B2

    公开(公告)日：2013-10-22

    申请号：US13151645

    申请日：2011-06-02

    申请人： Koichiro Matsumoto ,  Yoshiyuki Kono ,  Hitomi Honda ,  Akitoshi Mizutani

    发明人： Koichiro Matsumoto ,  Yoshiyuki Kono ,  Hitomi Honda ,  Akitoshi Mizutani

    IPC分类号： G06F15/00 ,  G01B7/30

    CPC分类号： G01D5/145

    摘要： A rotation angle detector is provided with a frame-shaped yoke which includes a first wall and a second wall in parallel. A rotation axis of a detection subject extends inside of the frame-shaped yoke. A magnetic flux vector is uniformed in a direction orthogonal to the first wall, whereby even if a position of a Hall element deviates, the detected magnetic flux density is less varied. A robustness of the detector is enhanced. A distance between the Hall element and a second inner surface of the second wall is shorter than that between the Hall element and a first inner surface of the first wall. A length of the second inner surface is longer than a length of the first inner surface. At a vicinity of the second wall, the area in which the magnetic flux vector is uniformed can be enlarged. Thus, the robustness is further enhanced.

    摘要翻译： 一个旋转角度检测器设置有一个框架状的轭，它包括第一壁和第二壁并联。 检测对象的旋转轴在框状轭的内部延伸。 磁通矢量在与第一壁正交的方向上是均匀的，由此即使霍尔元件的位置偏离，检测的磁通密度变化较小。 增强了检测器的鲁棒性。 霍尔元件与第二壁的第二内表面之间的距离比霍尔元件和第一壁的第一内表面之间的距离短。 第二内表面的长度比第一内表面的长度长。 在第二壁附近，可以扩大磁通矢量均匀的区域。 因此，鲁棒性进一步提高。

    MAGNETIC DETECTION APPARATUS
    9.
    发明申请
    MAGNETIC DETECTION APPARATUS 审中-公开
    磁性检测装置

    公开(公告)号：US20120306484A1

    公开(公告)日：2012-12-06

    申请号：US13460876

    申请日：2012-05-01

    申请人： Akitoshi Mizutani ,  Naoaki Kouno ,  Hitomi Honda ,  Tomoyuki Takiguchi

    发明人： Akitoshi Mizutani ,  Naoaki Kouno ,  Hitomi Honda ,  Tomoyuki Takiguchi

    IPC分类号： G01R33/02 ,  B29C45/14

    CPC分类号： G01R33/07 ,  G01D5/145 ,  G01D11/245

    摘要： A magnetic detection apparatus includes an IC device, a casing defining a housing space of the IC device, and a resin mold portion arranged on a first part of an outside surface of the casing. The IC device includes an IC package having a built-in magnetoelectric transducer, and lead wires. The housing space is defined by a second part of an inner wall of the casing. A predetermined portion of the second part of the inner wall is defined as a contact region, with which the IC device contacts. The resin mold portion is arranged other than a predetermined portion of a second part of the outside surface corresponding to the contact region. A position of the magnetoelectric transducer is determined by positions of the contact region and the resin mold portion.

    摘要翻译： 磁性检测装置包括IC器件，限定IC器件的容纳空间的壳体和布置在壳体的外表面的第一部分上的树脂模制部分。 IC器件包括具有内置磁电换能器的IC封装和引线。 容纳空间由壳体的内壁的第二部分限定。 内壁的第二部分的预定部分被定义为与IC器件接触的接触区域。 树脂模具部分布置成与对应于接触区域的外表面的第二部分的预定部分不同。 磁电换能器的位置由接触区域和树脂模具部分的位置决定。

    ROTATION ANGLE DETECTOR
    10.
    发明申请
    ROTATION ANGLE DETECTOR 有权
    旋转角度检测器

    公开(公告)号：US20110301913A1

    公开(公告)日：2011-12-08

    申请号：US13151645

    申请日：2011-06-02

    申请人： Koichiro MATSUMOTO ,  Yoshiyuki Kono ,  Hitomi Honda ,  Akitoshi Mizutani

    发明人： Koichiro MATSUMOTO ,  Yoshiyuki Kono ,  Hitomi Honda ,  Akitoshi Mizutani

    IPC分类号： G06F15/00 ,  G01B7/30

    CPC分类号： G01D5/145

    摘要： A rotation angle detector is provided with a frame-shaped yoke which includes a first wall and a second wall in parallel. A rotation axis of a detection subject extends inside of the frame-shaped yoke. A magnetic flux vector is uniformed in a direction orthogonal to the first wall, whereby even if a position of a Hall element deviates, the detected magnetic flux density is less varied. A robustness of the detector is enhanced. A distance between the Hall element and a second inner surface of the second wall is shorter than that between the Hall element and a first inner surface of the first wall. A length of the second inner surface is longer than a length of the first inner surface. At a vicinity of the second wall, the area in which the magnetic flux vector is uniformed can be enlarged. Thus, the robustness is further enhanced.

    摘要翻译： 一个旋转角度检测器设置有一个框架状的轭，它包括第一壁和第二壁并联。 检测对象的旋转轴在框状轭的内部延伸。 磁通矢量在与第一壁正交的方向上是均匀的，由此即使霍尔元件的位置偏离，检测的磁通密度变化较小。 增强了检测器的鲁棒性。 霍尔元件与第二壁的第二内表面之间的距离比霍尔元件和第一壁的第一内表面之间的距离短。 第二内表面的长度比第一内表面的长度长。 在第二壁附近，可以扩大磁通矢量均匀的区域。 因此，鲁棒性进一步提高。