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    CONFOCAL IMAGING METHODS AND APPARATUS
    1.
    发明申请
    CONFOCAL IMAGING METHODS AND APPARATUS 有权
    协同成像方法和装置

    公开(公告)号：US20150069267A1

    公开(公告)日：2015-03-12

    申请号：US14489727

    申请日：2014-09-18

    申请人： Illumina, Inc.

    发明人： Wenyi Feng ,  Theofilos Kotseroglou ,  Mark Wang ,  Alexander Triener ,  Diping Che ,  Robert Kain

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6456 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2021/6421 ,  G02B21/0032 ,  G02B21/004

    摘要： The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.

    摘要翻译： 本发明提供了用于以快速扫描速率获得样品的高分辨率图像的成像装置和方法。 具有比垂直尺寸长的水平尺寸的矩形检测器阵列可以与定位成将样本的一部分的矩形图像引导到矩形检测器阵列的成像光学元件一起使用。 扫描装置可以被配置成以扫描轴尺寸扫描样本，其中矩形检测器阵列的垂直尺寸和图像的两个矩形尺寸中的较短的尺寸在扫描轴尺寸上，并且其中垂直尺寸 因为矩形检测器阵列足够短以在单个轴上实现共焦。

    INTEGRATED OPTOELECTRONIC READ HEAD AND FLUIDIC CARTRIDGE USEFUL FOR NUCLEIC ACID SEQUENCING
    2.
    发明申请
    INTEGRATED OPTOELECTRONIC READ HEAD AND FLUIDIC CARTRIDGE USEFUL FOR NUCLEIC ACID SEQUENCING 有权
    用于核酸序列的集成光电阅读头和流体盒

    公开(公告)号：US20140329694A1

    公开(公告)日：2014-11-06

    申请号：US14335117

    申请日：2014-07-18

    申请人： ILLUMINA, INC.

    发明人： Dale Buermann ,  John A. Moon ,  Bryan Crane ,  Mark Wang ,  Stanley S. Hong ,  Jason Harris ,  Matthew Hage ,  Mark J. Nibbe

    IPC分类号： C12Q1/68

    CPC分类号： B01L3/527 ,  B01L3/502715 ,  B01L2200/16 ,  B01L2300/0877 ,  B01L2400/0487 ,  B01L2400/06 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N21/6428 ,  G01N21/6486 ,  G01N2021/0307 ,  G01N2021/0325 ,  G01N2021/058 ,  G01N2021/6417 ,  G01N2021/6441 ,  G01N2021/6482

    摘要： A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.

    摘要翻译： 一种检测装置，具有包括多个微量荧光计的读取头，所述多个微量荧光计定位成在公共平面中同时获取多个所述宽视场图像; 和（b）平移台，其配置成沿着位于公共平面中的基板移动读取头。 基底可以是包含在药筒中的流动池，药筒还包括用于（i）样品储存器的壳体; （ii）样品储存器和流动池之间的流体管线; （iii）与所述流动池流体连通的若干试剂储存器，（iv）至少一个构造成介导所述储存器与所述流动池之间的流体连通的阀; 和（v）至少一个压力源，其构造成将液体从储存器移动到流动池。 检测装置和盒可以一起使用或彼此独立使用。

    INTEGRATED OPTOELECTRONIC READ HEAD AND FLUIDIC CARTRIDGE USEFUL FOR NUCLEIC ACID SEQUENCING
    3.
    发明申请
    INTEGRATED OPTOELECTRONIC READ HEAD AND FLUIDIC CARTRIDGE USEFUL FOR NUCLEIC ACID SEQUENCING 有权
    用于核酸序列的集成光电阅读头和流体盒

    公开(公告)号：US20130260372A1

    公开(公告)日：2013-10-03

    申请号：US13766413

    申请日：2013-02-13

    申请人： ILLUMINA, INC.

    发明人： Dale Buermann ,  John A. Moon ,  Bryan Crane ,  Mark Wang ,  Stanley S. Hong ,  Jason Harris ,  Matthew Hage ,  Mark J. Nibbe

    IPC分类号： C12Q1/68

    CPC分类号： B01L3/527 ,  B01L3/502715 ,  B01L2200/16 ,  B01L2300/0877 ,  B01L2400/0487 ,  B01L2400/06 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N21/6428 ,  G01N21/6486 ,  G01N2021/0307 ,  G01N2021/0325 ,  G01N2021/058 ,  G01N2021/6417 ,  G01N2021/6441 ,  G01N2021/6482

    摘要： A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.

    摘要翻译： 一种检测装置，具有包括多个微量荧光计的读取头，所述多个微量荧光计定位成在公共平面中同时获取多个所述宽视场图像; 和（b）平移台，其配置成沿着位于公共平面中的基板移动读取头。 基底可以是包含在药筒中的流动池，药筒还包括用于（i）样品储存器的壳体; （ii）样品储存器和流动池之间的流体管线; （iii）与所述流动池流体连通的若干试剂储存器，（iv）至少一个构造成介导所述储存器与所述流动池之间的流体连通的阀; 和（v）至少一个压力源，其构造成将液体从储存器移动到流动池。 检测装置和盒可以一起使用或彼此独立使用。

    INTEGRATED OPTOELECTRONIC READ HEAD AND FLUIDIC CARTRIDGE USEFUL FOR NUCLEIC ACID SEQUENCING
    6.
    发明申请
    INTEGRATED OPTOELECTRONIC READ HEAD AND FLUIDIC CARTRIDGE USEFUL FOR NUCLEIC ACID SEQUENCING 审中-公开

    公开(公告)号：US20170246635A1

    公开(公告)日：2017-08-31

    申请号：US15594413

    申请日：2017-05-12

    申请人： Illumina, Inc.

    发明人： Dale Buermann ,  John A. Moon ,  Bryan Crane ,  Mark Wang ,  Stanley S. Hong ,  Jason Harris ,  Matthew Hage ,  Mark J. Nibbe

    IPC分类号： B01L3/00 ,  C12Q1/68

    摘要： A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.

    INTEGRATED OPTOELECTRONIC READ HEAD AND FLUIDIC CARTRIDGE USEFUL FOR NUCLEIC ACID SEQUENCING
    10.
    发明申请
    INTEGRATED OPTOELECTRONIC READ HEAD AND FLUIDIC CARTRIDGE USEFUL FOR NUCLEIC ACID SEQUENCING 有权

    公开(公告)号：US20230137970A1

    公开(公告)日：2023-05-04

    申请号：US18091116

    申请日：2022-12-29

    申请人： ILLUMINA, INC.

    发明人： Dale Buermann ,  John A. Moon ,  Bryan Crane ,  Mark Wang ,  Stanley S. Hong ,  Jason Harris ,  Matthew Hage ,  Mark J. Nibbe

    IPC分类号： B01L3/00 ,  C12Q1/6869 ,  G01N21/64 ,  C12Q1/6874

    摘要： A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir, (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.