公开(公告)号：US20210299661A1

公开(公告)日：2021-09-30

申请号：US16500787

申请日：2018-04-02

申请人： ILLUMINA, INC.

发明人： Sz-Chin Steven LIN ,  Richard LEMOINE ,  Rajagopal PANCHAPAKESAN ,  Wesley A. COX-MURANAMI ,  Darren SEGALE

IPC分类号： B01L3/00 ,  G01M3/28 ,  F16K99/00

摘要： A method includes engaging a well of a cartridge with a flow sensor of an instrument. The cartridge includes: a rotary valve including a rotatable port and a center port; the well in fluid communication with a channel, the channel including a channel port that the rotatable port is to align to in order to receive fluid from the well; and a flowcell including an inlet gasket in fluid communication with the center port. A source of pressurized air is connected to the flow sensor in order to establish a mass flow of air through a flow path. The flow path extends through one of the flow sensor, the channel, the rotary valve, and the flowcell. The mass flow of air through the flow path is measured with the flow sensor. It is determined if there is one of an air leak and an air blockage within the flow path.

公开(公告)号：US20240326038A1

公开(公告)日：2024-10-03

申请号：US18744268

申请日：2024-06-14

申请人： Illumina, Inc.

发明人： Wesley A. COX-MURANAMI ,  Kay KLAUSING ,  Bradley Kent DREWS ,  Nicholas WATSON ,  Jennifer Olivia FOLEY ,  Murphy HITCHCOCK ,  Paul SANGIORGIO ,  Sz-Chin Steven LIN

IPC分类号： B01L3/00

CPC分类号： B01L3/502 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2300/047 ,  B01L2300/06 ,  B01L2400/0487 ,  B01L2400/0644

摘要： A system includes a fluidic device, a flow control valve, a first reagent fluid reservoir fluidly connectable to the fluidic device by the flow control valve, a first fluid buffer reservoir fluidly connectable to the fluidic device by the flow control valve, and a common fluid buffer source fluidly connectable to the fluidic device by the flow control valve. The flow control valve permits flow comprising: (i) flow from the first reagent fluid reservoir to the fluidic device, (ii) flow from the common fluid buffer source to the fluidic device, (iii) flow from the fluidic device to the first fluid buffer reservoir, (iv) flow from the first reagent fluid reservoir to the fluidic device, and (v) flow from the first fluid buffer reservoir to the fluidic device.

公开(公告)号：US20240319224A1

公开(公告)日：2024-09-26

申请号：US18732450

申请日：2024-06-03

申请人： Illumina, Inc.

发明人： Wesley A. COX-MURANAMI ,  James OSMUS ,  Paul CRIVELLI ,  Bradley Kent DREWS

IPC分类号： G01N35/10

CPC分类号： G01N35/1097

摘要： An apparatus includes a fluidic circuit, a bypass fluidic circuit, a first set of fluid wells, a second set of fluid wells, a first valve, and a second valve. The first valve operatively associated with the first set of fluid wells such that the first selectively fluidly connects any one of the first set of fluid wells to a first valve outlet. The second valve operatively associated with the fluidic circuit, the bypass fluidic circuit, the first valve outlet, and the second set of fluid wells such that the second valve selectively fluidly connects any one of the second set of fluid wells and the first valve outlet to the fluidic circuit or the first valve outlet to the bypass fluidic circuit.

公开(公告)号：US20220371005A1

公开(公告)日：2022-11-24

申请号：US17817204

申请日：2022-08-03

申请人： Illumina, Inc.

发明人： Wesley A. COX-MURANAMI ,  Kay KLAUSING ,  Bradley Kent DREWS ,  Nicholas WATSON ,  Jennifer Olivia FOLEY ,  Murphy HITCHCOCK ,  Paul SANGIORGIO ,  Sz-Chin Steven LIN

IPC分类号： B01L3/00

摘要： A system includes a fluidic device, a flow control valve, a first reagent fluid reservoir fluidly connectable to the fluidic device by the flow control valve, a first fluid buffer reservoir fluidly connectable to the fluidic device by the flow control valve, and a common fluid buffer source fluidly connectable to the fluidic device by the flow control valve. The flow control valve permits flow comprising: (i) flow from the first reagent fluid reservoir to the fluidic device, (ii) flow from the common fluid buffer source to the fluidic device, (iii) flow from the fluidic device to the first fluid buffer reservoir, (iv) flow from the first reagent fluid reservoir to the fluidic device, and (v) flow from the first fluid buffer reservoir to the fluidic device.

公开(公告)号：US20190224676A1

公开(公告)日：2019-07-25

申请号：US16244776

申请日：2019-01-10

申请人： Illumina, Inc. ,  Illumina Cambridge Limited

发明人： Wesley A. COX-MURANAMI ,  Darren Robert SEGALE ,  Oliver Jon MILLER ,  Jennifer Olivia FOLEY ,  Tarun Kumar KHURANA ,  Paul CRIVELLI ,  Gary WATTS

IPC分类号： B01L3/00 ,  G01N1/31

摘要： An apparatus for directing fluid into and out of a fluidic device includes two or more fluid prime channels connected to a fluid inlet of the fluidic device, a flow control valve for each fluid prime channel to control flow between the fluid prime channel and the fluid inlet, one or more outlet channels connected to a fluid outlet of the fluidic device, and a flow control valve for each outlet channel to control flow between the fluid outlet and the associated outlet channel. An apparatus for delivering fluids to a fluid inlet includes a plate that is rotatable about an axis of rotation and a plurality of fluid compartments disposed on the plate, each compartment having a fluid exit port disposed at a common radial distance from the axis of rotation and positioned to align with the fluid inlet as the plate rotates about the axis of rotation.